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Objective: To find effective therapeutic approach for treating true idiopathic precocious puberty suitable to our national condition and different from gonadotrophin releasing hormone agonist., Methods: One hundred and six girls with idiopathic precocious puberty were divided into 3 groups. The 51 girls in the combination therapy group were treated with megestrol acetate (MA) and Chinese medicine for nourishing Yin and removing Fire, the 35 girls in the MA treated group were treated with MA alone and the other 20 girls were given no treatment at all as control. Luteinizing hormone releasing hormone (LHRH) stimulating test was performed before and after treatment, and size of uterus and ovary, linear growth rate, X-ray bone age measurement and final height prediction were also observed simultaneously., Results: After being treated with combination therapy for 2.7 years in average, in the combination therapy group, the luteinizing hormone peak value of LHRH stimulating test was reduced from 48.5 +/- 37.1 IU/L to 12.2 +/- 9.3 IU/L (P < 0.001), size of uterus and ovary decreased, secondary sexual characteristics regressed, the bone age difference/chronological age difference value (delta BA/delta CA) reduced from 1.35 +/- 0.64 to 0.65 +/- 0.36(P < 0.001), and predictive final height increased from 153.3 +/- 3.6 cm to 158.5 +/- 4.3 cm (P < 0.001)., Conclusion: Combination therapy could not only modulate the function of hypothalamic-pituitary-ovarian axis and the development of internal genitalia, but also could slow down skeletal growth, delay skeletal maturation, and thereby prevent premature epiphyseal fusion and increase the final height of patients.

One hundred and seventy children with cough were divied into two groups at random. 120 patient were treated with Zhenkeling oral liquor (ZKL group). The other 50 children were given pectoral syrup (control group). The results showed that the total effective rates of ZKL group and control group were 96.7% and 56.0% respectively, and the markedly effective rates were 80.8%, 18.0% respectively (P < 0.001). Animal experiments indicated Zhenkeling has the effect of relieving cough, reducing sputum and ameliorating asthma; their antibiotic and anti-inflammatory effects were discovered too. The dosage of Zhenkeling was 100 times as clinical dose in acute toxicity test and the dosage was 32, 16, 8 times as clinical dose in long term toxicity test respectively. No adverse action was found in these experiments.

The model of experimental atherosclerosis was established by means of dietary hyperlipidemia and repeated intravenous injection of heterologous serum to make the immunologic injuries of arterial endothelium, in which the effect of Ligusticum wallichii (LW) on the cerebrovascular hemodynamic parameters (CVHP) was observed. All CVHP indexes in LW group were near that of normal group, and there was no significant difference between these two groups. The carotid arteries' mean flow (Qmean), mean velocity (Vmean), maximal velocity (Vmax), cerebrovascular peripheral compliance for zero pressure and cerebrovascular peripheral resistance (R) in LW group were significantly better than that of atherosclerotic control group (P < 0.05-0.01). The results showed that LW had protective effects on cerebral vessels.

21 cases are fully agreed with the diagnosis standard of Schonlein-Henoch nephritis. Biopsy on the kidney of 5 cases with resistant duration was made and all were diagnosed as mesenteric hyperplastic glomerular nephritis, among them, one with segmental sclerosis, one with segmental sclerosis and crescents in some glomerulus. 13 cases were treated with prednisone, cyclophosphamide and Traditional Chinese herbs. 8 cases with wilfordine adding and/or traditional Chinese herbs. The results showed that 15 of 21 cases were cured, one case perfect remission, 4 cases part remission. All of the cases were followed-up from 2 years and 10 months to 12 years and 4 months, average 7.34 years. The late results: Group A, 16 cases with symptom, physical exam, urine routine normal. Group B, 4 cases with microscopic hematuria and/or "a little-(+)" urinary protein. Group C, one case with "+2" urinary protein and/or hypertension, urinary creatinine clearance rate normal. Of 5 cases, whose biopsies of kidney were made, one with glomerular segmental sclerosis belonged to Group B. 13 of 21 cases had recurrence for 1-6 times, which was closed related with up respiratory tract infection.