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3 results on '"Mustafa Pehlivan"'

1. Impact of UCP2 -866G/A Variant on Smoking Risk

Author

Ayşe Feyda NURSAL, Mehmet Atilla UYSAL, Mustafa PEHLİVAN, Ülgen SEVER, and Sacide PEHLİVAN

Subjects
smoking status, ucp2, variant, pcr-rflp, Medicine (General), R5-920
Abstract

Objective:Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been reported to affect mitochondrial function both in vitro and in vivo. Uncoupling protein 2 (UCP2) reduces generation of ROS by mitochondria. Our purpose in this study was to investigate whether the -866G/A variant of the UCP2 gene is associated with smoking status.Methods:A total of 238 individuals consisting of 138 smokers and 100 healthy controls were examined. The UCP2-866G/A variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism method.Results:The proportion of individuals carrying the three possible genotype was significantly different between the smoker and healthy control groups. The UCP2-866G/A variant GG genotype was associated significantly with an increased risk of smoking (p=0.001) while AA genotype was associated significantly with a decreased risk of smoking (p=0.001). The UCP2-866G/A variant G allele was found to be increased in the smoker group compared to the healthy controls (p=0.001).Conclusion:Our data suggest that the UCP2-866 G/A variant GG genotype and G allele might reflect the risk of smoking status in a Turkish population.

Published
2021
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2. Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival

Author

Ali Caner Özdöver, İlknur Gündeş, Melya Pelin Kırık, Handan Haydaroğlu Şahin, Murat Sucu, and Mustafa Pehlivan

Subjects
hematopoietic stem cell transplantation, pulmonary artery pressure, overall survival, Diseases of the blood and blood-forming organs, RC633-647.5
Abstract

Objective: Hematopoietic stem cell transplantation (HSCT) is a choice of treatment for malignant and non-malignant diseases. After HSCT, some complications may develop in patients. Cardiac complications are particularly important. The aim of this study was to investigate whether systolic pulmonary artery pressure (PAP) is a marker for overall survival (OS) in HSCT patients. Materials and Methods: In our study, 428 HSCT patients were evaluated. Ejection fraction (EF) and PAP values were investigated during symptom-oriented echocardiography in the pre-HSCT and post-HSCT periods. Results: Pre-HSCT EF values were similar between the groups. In patients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it was found that the 5-year mortality rate was 48.6%, while in the other group (PAP 25 mmHg, while OS was 61% in the pre-auto-HSCT period with PAP values of 0.05). Conclusion: Our results suggest that pre-HSCT PAP value is an important risk factor for mortality and OS in patients undergoing auto-HSCT.

Published
2019
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3. UCP2 -866G/A Varyantının Sigara İçme Durumuna Etkisi

Author

Ulgen Sever, Ayse Feyda Nursal, Mustafa Pehlivan, Mehmet Atilla Uysal, Sacide Pehlivan, and [Belirlenecek]

Subjects
ucp2, lcsh:R5-920, variant, business.industry, Environmental health, General Engineering, [No Keywords], Medicine, pcr-rflp, business, lcsh:Medicine (General), smoking status
Abstract

Objective: Mitochondria are multifunctional and dynamic organelles found in cells. Nicotine is a natural alkaloid found in the tobacco plant and has been well studied as a component of cigarette smoke. It has also been reported to affect mitochondrial function both in vitro and in vivo. Uncoupling protein 2 (UCP2) reduces generation of ROS by mitochondria. Our purpose in this study was to investigate whether the -866G/A variant of the UCP2 gene is associated with smoking status. Methods: A total of 238 individuals consisting of 138 smokers and 100 healthy controls were examined. The UCP2-866G/A variant was genotyped by polymerase chain reaction-restriction fragment length polymorphism method. Results: The proportion of individuals carrying the three possible genotype was significantly different between the smoker and healthy control groups. The UCP2-866G/A variant GG genotype was associated significantly with an increased risk of smoking (p=0.001) while AA genotype was associated significantly with a decreased risk of smoking (p=0.001). The UCP2-866G/A variant G allele was found to be increased in the smoker group compared to the healthy controls (p=0.001). Conclusion: Our data suggest that the UCP2-866 G/A variant GG genotype and G allele might reflect the risk of smoking status in a Turkish population Amaç: Mitokondriler hücrelerde bulunan çok fonksiyonlu ve dinamik organellerdir. Nikotin tütün bitkisinde bulunan doğal bir alkaloiddir ve sigara içme durumunun iyi çalışılmış bir bileşenidir. Nikotinin in vitro ve in vivo olarak mitokondriyal fonksiyonu etkilediği rapor edilmiştir. Uncoupling protein 2 (UCP2) mitokondri ile ROS üretimini azaltır. Bu çalışmadaki amacımız UCP2-866G/A varyantının sigara içme durumu ile ilişkili olup olmadığını araştırmaktır. Yöntemler: Yüz otuz sekiz sigara içen ve 100 sağlıklı kontrolden oluşan toplam 238 kişi değerlendirildi. UCP2-866G/A varyantı polimeraz zincir reaksiyonu-sınırlayıcı enzim parça uzunluk çeşitliliği metodu ile genotiplendi. Bulgular: Üç olası genotipi taşıyan kişileri oranı sigara içenler ve sağlıklı kontrol grupları arasında belirgin şekilde farklıydı. UCP2- 866G/A varyantı AA genotipi belirgin şekilde azalmış sigara içme riski ile ilişkiyken (p=0,001), GG genotipi belirgin şekilde artmış sigara içme durumu ile ilişkiliydi (p=0,001). UCP2-866G/A varyant G alelinin sigara içen grupta sağlıklı kontrollere göre artmış olduğu bulundu (p=0,001). Sonuç: Verilerimiz UCP2-866 G/A varyant GG genotip ve G alelin Türk popülasyonundaki sigara içme riskini yansıtabileceğini desteklemektedir. WOS:000640072700012

Published
2021

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