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1. Intramuscular Short-term ACTH Test for the Determination of Adrenal Function in Children: Safe, Effective and Reliable

Author

Elif Özsu, Zeynep Şıklar, Esra Bilici, Ayşegül Ceran, Rukiye Uyanık, Tuğba Çetin, Zehra Aycan, and Merih Berberoğlu

Subjects
adrenal insufficiency, intramuscular acth, childhood, reliability, Pediatrics, RJ1-570, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Objective:Standard short adrenocorticotropic hormone (ACTH) stimulation test (SST) has traditionally been used for assessing adrenal gland fuction by intravenous (iv) application. However the iv form is not readily available in all countries, including Turkey. The aim of this study was to evaluate the effectiveness of the intramuscular (im) SST.Methods:Patients underwent im SST with suspected adrenal insufficiency (AI) and hyperandrogenism. The SSTs were done with 250 mcg ACTH (Synacthen Depot ampul, concentration 1 mg/mL). The cases were divided into two groups: suspected AI (group 1 n=87); and hyperandrogenism group (group 2 n=124). Definite AI was defined as peak cortisol

Published
2020
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2. Intramuscular Short-term ACTH Test for the Determination of Adrenal Function in Children: Safe, Effective and Reliable

Author

Rukiye Uyanik, Zehra Aycan, Merih Berberoğlu, Esra Bilici, Elif Ozsu, Tuğba Çetin, Zeynep Şıklar, and Aysegul Ceran

Subjects
Male, Time Factors, Turkey, Endocrinology, Diabetes and Metabolism, Synacthen depot, Stimulation, 030204 cardiovascular system & hematology, Gastroenterology, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 0302 clinical medicine, Endocrinology, Adrenal function, Child, Adrenal gland, lcsh:RJ1-570, medicine.anatomical_structure, Child, Preschool, Original Article, Female, adrenal insufficiency, hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, endocrine system, Adolescent, 030209 endocrinology & metabolism, Adrenocorticotropic hormone, Injections, Intramuscular, Young Adult, 03 medical and health sciences, Adrenocorticotropic Hormone, Predictive Value of Tests, Internal medicine, medicine, Adrenal insufficiency, Humans, Congenital adrenal hyperplasia, intramuscular acth, Retrospective Studies, childhood, reliability, lcsh:RC648-665, Adrenal Hyperplasia, Congenital, business.industry, Hyperandrogenism, Infant, Reproducibility of Results, lcsh:Pediatrics, medicine.disease, Pediatrics, Perinatology and Child Health, Adrenal Cortex Function Tests, business
Abstract

Objective: Standard short adrenocorticotropic hormone (ACTH) stimulation test (SST) has traditionally been used for assessing adrenal gland fuction by intravenous (iv) application. However the iv form is not readily available in all countries, including Turkey. The aim of this study was to evaluate the effectiveness of the intramuscular (im) SST. Methods: Patients underwent im SST with suspected adrenal insufficiency (AI) and hyperandrogenism. The SSTs were done with 250 mcg ACTH (Synacthen Depot ampul, concentration 1 mg/mL). The cases were divided into two groups: suspected AI (group 1 n=87); and hyperandrogenism group (group 2 n=124). Definite AI was defined as peak cortisol

Published
2020

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