1. [A case of liver metastasis of rectal cancer demonstrating complete response to 5-FU + Leucovorin + UFT].
- Author
-
Ishida H, Ohsawa T, Takeuchi I, Nakada H, Inokuma S, Hoshino T, and Daijo H
- Subjects
- Drug Administration Schedule, Drug Combinations, Fluorouracil administration & dosage, Humans, Leucovorin administration & dosage, Male, Middle Aged, Rectal Neoplasms pathology, Remission Induction, Tegafur administration & dosage, Uracil administration & dosage, Adenocarcinoma drug therapy, Adenocarcinoma secondary, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Liver Neoplasms secondary, Rectal Neoplasms drug therapy
- Abstract
Dihydropyrimidine dehydrogenase (DPD) is a rate-limiting enzyme that metabolizes 5-fluorouracil (5-FU). We report a patient with metachronous liver metastasis from rectal cancer with low expression of DPD, who demonstrated complete response to chemotherapy comprising 5-FU, Leucovorin, and UFT. A 53-year-old man underwent macroscopically curative proctectomy with coloanal anastomosis for lower rectal cancer (Curability B). The DPD level in the primary tumor determined by an enzyme-linked immunosorbent assay was extremely low (10.3 U/mg.protein). Three months postoperatively, 5-FU (333 mg/m2) + Leucovorin (200 mg/m2) therapy (once a week for 3 weeks with a one-week rest interval, repeatedly) was started as an adjuvant therapy. However, computed tomography demonstrated a solitary liver metastasis 3 cm in size 1 month later. Chemotherapy was continued with dose escalation of 5-FU (500 mg/m2) and with oral administration of UFT-E (400 mg/body, daily). Five months later, computed tomography did not detect the liver metastasis, and this finding was maintained for two months (complete response). This case provides evidence that a low expression of DPD in the primary lesion is related to a favorable response of liver metastasis to 5-FU-based systemic chemotherapy.
- Published
- 2002