1. A Catalyst-Free, Temperature-Driven One-Pot Synthesis of 1-Adamantylhydrazine Hydrochloride
- Author
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James Hodgson, Stefan H. Bossmann, Anjana M. D. S. Delpe Acharige, and Raul Neri
- Subjects
0303 health sciences ,010405 organic chemistry ,030306 microbiology ,Hydrochloride ,Organic Chemistry ,Extraction (chemistry) ,One-pot synthesis ,Organic layer ,01 natural sciences ,Combinatorial chemistry ,Catalysis ,0104 chemical sciences ,03 medical and health sciences ,chemistry.chemical_compound ,chemistry ,Yield (chemistry) ,Extraction methods - Abstract
1-Adamantylhydrazine can be a versatile intermediate for many biologically active compounds as adamantyl possesses a wide spectrum of medicinal properties. Described here is a detailed one-pot synthesis of 1-adamantylhydrazine, carried out on a milligram to gram scale, that steadily delivers a highly stable product used to carry out the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine for bacterial studies. The reaction employs inexpensive, catalyst free, readily available starting materials. In the synthesis of 1-(adamantan-1-yl)-1H-pyrazol-3-amine, the use of a continuous extraction method allows for complete extraction of the target product into the organic layer and increases the overall percentage yield.
- Published
- 2020
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