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45 results on '"Engels K"'

1. Erstdiagnose eines niedrig malignen Non-Hodgkin-Lymphoms (Immunozytom) bei Arthritis des Glenohumeralgelenks

Author

Engels K, Kerschbaumer F, Braune C, and Rittmeister M

Subjects
Leukemic Infiltration, Pathology, medicine.medical_specialty, business.industry, Chronic lymphocytic leukemia, Arthritis, Joint effusion, medicine.disease, Leukemia, Chronic leukemia, hemic and lymphatic diseases, Synovitis, Arthropathy, medicine, Orthopedics and Sports Medicine, Surgery, medicine.symptom, business
Abstract

Aim: Oligo- or monarthritis is reported as an uncommon complication of both acute and chronic leukemia. Childhood leukemias are complicated more frequently by leukemic arthritis (LA) than adult cases. LA occurs rather in acute than in chronic leukemia and can present at any stage of the disease. Proposed pathogenic mechanisms of arthritis in leukemia are leukemic infiltration of synovial tissue and resulting periosteal and capsular inflammation. As the primary manifestation of chronic lymphocytic leukemia (CLL) and immunocytoma (IC), LA is extremely rare. In such cases osteoarthritis may then be misdiagnosed as the source of joint disease. Method: We report a case of glenohumeral arthritis with complete rotator cuff tear and humeral head migration in an 88-year-old patient. Surgery exposed joint effusion, synovitis and chondromalacia with glenohumeral joint destruction. Results: Histopathological examination revealed an articular chondrocalcinosis and bone marrow infiltration by an immunocytoma (B-cell non-Hodgkin lymphoma of low malignancy). Conclusion: Although LA is an uncommon complication in CLL and IC, it may be considered in elderly patients with lymphocytosis and arthritis.

Published
2002
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2. Immunhistochemischer Nachweis des 'epidermal growth factor receptor (EGF-R)' an Paraffinschnitten von Mammakarzinomgeweben: Korrelationen und klinische Wertigkeit

Author

H.-G. Schnürch, Boris Tutschek, Engels K, F. Picard, U.J. Göhring, M. W. Beckmann, Anton Scharl, and Dieter Niederacher

Subjects
Pathology, medicine.medical_specialty, biology, Receptor expression, Mammary gland, Obstetrics and Gynecology, medicine.disease, medicine.anatomical_structure, Breast cancer, Epidermal growth factor, Maternity and Midwifery, medicine, biology.protein, Carcinoma, Immunohistochemistry, Epidermal growth factor receptor, Lymph node, hormones, hormone substitutes, and hormone antagonists
Abstract

Analyses of the level of expression of the epidermal growth factor receptor (EGF-R) of breast cancer tumours may add independent information about the prognosis for individual patients. Furthermore, the use of monoclonal antibodies directed against EGF-R as therapeutic tools (e.g., Mab 425) requires a reliable evaluation of the individual EGF-R content. Various analytical methods have been published, including (1) biochemical detectonn of EGF-R by a radiolabelled physiological ligand, (125I)EGF, (2) enzymatic analyses of EGF-R content (IEMA), (3) immunological analyses of EGF-R content with a monoclonal antibody (ELISA), and (4) immunohistochemical EGF-R detection. Studies with immunohistochemical analyses of EGF-R overexpression in formalin-fixed, paraffin-embedded tumour samples are rare. In a retrospective study, we examined the clinical data from 142 patients and the EGF-R expression in their formalin-fixed, paraffin-embedded tumour samples. The average follow-up was 69 months. EGF-R expression was compared to oestrogen (ER) and progesterone (PgR) receptor expression, histological grade, tumour size, lymph node metastases and menopause. 52 of 142 tumours were EGF-R positive. EGF-R overexpression correlated with high tumour grade, large tumours and elevated numbers of lymph node metastases. There was no significant correlation between ER or PgR and EGF-R expression. Determination of EGF-R overexpression revealed no significant difference in disease-free interval (DFI) or overall survival (OS). In this study, the determination of EGF-R in formalin-fixed, paraffin-embedded tumour samples proved feasible. Unfortunately, this did not add any additional information concerning DFI or OS.

Published
1995
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10. Investigation of potential effects on thyroglobulin processing enzymes and thyroid hormone transporters in thyroid glands of mice with induced hypo- or hyperthyroidism

Author

Rehders, M, primary, Weber, J, additional, Engels, K, additional, Rakov, H, additional, Hönes, S, additional, Führer, D, additional, Biebermann, H, additional, Wirth, E, additional, Schweizer, U, additional, Heuer, H, additional, Möller, L, additional, and Brix, K, additional

Published
2014
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