1. Relationship between angiographic graft vessel disease and microvascular reaction after heart transplantation
- Author
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Nicola E. Hiemann, Rudolf Meyer, Roland Hetzer, Manfred Hummel, and Ernst Wellnhofer
- Subjects
Heart transplantation ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Disease ,Diagnostic tools ,Endothelial stem cell ,Coronary arteries ,medicine.anatomical_structure ,Internal medicine ,Cardiology ,Medicine ,In patient ,Transplant patient ,Cardiology and Cardiovascular Medicine ,business ,Angiology - Abstract
This study tests the correlation of coronary angiographic findings with the extent of microvascular reaction in right ventricular endomyocardial biopsies (EMBs) in transplanted hearts. In EMBs (n = 209) of 30 heart transplant patients (8 female, 22 male, mean age 48 years) microvascular reaction, i.e. endothelial cell swelling and vascular wall thickening (both grade 0-2), was graded by light microscopy at ×200. Patients' first and last coronary angiography (CA) (mean time after heart transplantation [HTx] 8 and 44 months) were graded according to the Stanford Classification and the presence of diameter irregularities was evaluated semi-quantitatively. We found a correlation of angiographic type B lesions with endothelial cell swelling during the first 5 months and vascular wall thickening during the fifth to fourteenth month after HTx (p
- Published
- 2011
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