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114 results on '"Itharat A"'

2. In vitro and cellular antioxidant activities of Antidesma thwaitesianum Müll. Arg. (Euphorbiaceae) leaf extracts

Author

Pintusorn Hansakul, Bhanuz Dechayont, Nitra Nuengchamnong, and Arunporn Itharat

Subjects
Pharmacology, Antidesma, Antioxidant, biology, Traditional medicine, Chemistry, medicine.medical_treatment, Organic Chemistry, Euphorbiaceae, Pharmaceutical Science, biology.organism_classification, In vitro, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, medicine, Molecular Medicine
Published
2016

3. Cytotoxic activities against two lung cancer cells of Thai antipyretic drug

Author

Arunporn Itharat, S Ruangnoo, and T Juckmeta

Subjects
Pharmacology, business.industry, Organic Chemistry, Pharmaceutical Science, medicine.disease, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Molecular Medicine, Medicine, Cytotoxic T cell, business, Antipyretic drugs, Lung cancer
Published
2016

5. Comparison of genotoxicity potentials between crude Thai bee pollen and its extracts

Author

S Thitiorul, T Ratanavalachai, Wantha Jenkhetkan, Chalerm Jansom, and Arunporn Itharat

Subjects
Pharmacology, Complementary and alternative medicine, Traditional medicine, Bee pollen, Organic Chemistry, Drug Discovery, medicine, Pharmaceutical Science, Molecular Medicine, Biology, medicine.disease_cause, Genotoxicity, Analytical Chemistry
Published
2016

6. Cytotoxic activity against liver cancer cell [HepG2] of a Thai traditional remedy used for liver cancer treatment

Author

A Itharat, T Tui-on, and P Maki

Subjects
Pharmacology, Oncology, medicine.medical_specialty, business.industry, Organic Chemistry, Cell, Pharmaceutical Science, medicine.disease, Analytical Chemistry, medicine.anatomical_structure, Complementary and alternative medicine, Internal medicine, Drug Discovery, medicine, Molecular Medicine, Cytotoxic T cell, Liver cancer, business
Published
2016

8. Rhizome weight and bioactive compounds of Dioscorea birmanica under different shading

Author

Srisopa Ruangnoo, Arunporn Itharat, Yaowapha Jirakiattikul, Panumart Rithichai, and P Khemwichai

Subjects
Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Botany, Pharmaceutical Science, Molecular Medicine, Shading, Biology, Dioscorea birmanica, Analytical Chemistry, Rhizome
Published
2016

21. Protective effects of Dioscorea membranacea rhizome ethanolic extract against doxorubicin-induced genotoxicity in human lymphocytes in vitro

Author

N Runraksa, S Thitiorul, T Ratanavalachai, Srisopa Ruangnoo, and Arunporn Itharat

Subjects
Pharmacology, Traditional medicine, Organic Chemistry, Pharmaceutical Science, Biology, medicine.disease_cause, In vitro, Analytical Chemistry, Rhizome, Complementary and alternative medicine, Drug Discovery, medicine, Molecular Medicine, Doxorubicin, Dioscorea membranacea, Genotoxicity, medicine.drug
Published
2015

22. Anti-apoptotic effect of Phyllanthus emblica extract prevents contrast-induced acute kidney injury in rats

Author

A Tasanarong, Arunporn Itharat, and S Kongkham

Subjects
Pharmacology, Traditional medicine, business.industry, media_common.quotation_subject, Organic Chemistry, Acute kidney injury, Pharmaceutical Science, medicine.disease, Analytical Chemistry, Complementary and alternative medicine, Apoptosis, Phyllanthus emblica, Drug Discovery, medicine, Molecular Medicine, Contrast (vision), business, media_common
Published
2015

34. In vitro antioxidant activities of Bauhinia strychnifolia extracts: Comparison with green tea extracts

Author

Pintusorn Hansakul, S Sayompark, Arunporn Itharat, and Bhanuz Dechayont

Subjects
Pharmacology, Bauhinia strychnifolia, Antioxidant, Traditional medicine, Chemistry, medicine.medical_treatment, Organic Chemistry, Pharmaceutical Science, Green tea, In vitro, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Botany, medicine, Molecular Medicine
Published
2014

37. Cholinesterase inhibitory activities of Apai-sa-le recipe and its ingredients

Author

Arunporn Itharat, Pimolvan Senavong, Chitsanucha Sattaponpan, and Silavat Suk-um

Subjects
Pharmaceutical Science, Gas Chromatography-Mass Spectrometry, Lepidium sativum, Analytical Chemistry, chemistry.chemical_compound, Drug Discovery, Humans, Potency, Nootropic Agents, Butyrylcholinesterase, Angelica, Cholinesterase, Pharmacology, biology, Traditional medicine, Plant Extracts, Apiol, Angelica dahurica, Organic Chemistry, Atractylodes, biology.organism_classification, Acetylcholinesterase, Complementary and alternative medicine, chemistry, Piperine, biology.protein, Molecular Medicine, Cholinesterase Inhibitors, Plant Preparations, Atractylodes lancea, Piper nigrum
Abstract

Background: Acetylcholinesterase and butyrylcholoinesterase inhibitors are well-known drugs commonly used in the treatment of Alzheimer’s disease (AD) to improve cognitive function. These enzyme inhibitors were reported to be found in many plants. Apai-sa-le recipe was a Thai tradition used as nootropic recipe and formerly claimed to improve memory. Therefore, it is interesting to investigate cholinesterase inhibitory activity of the recipe and its ingredients. Objective: To determine the whole recipe of Apai-sa-le and its ingredients for inhibitory effect on acetylcholinesterase (AChE) and human butyrylcholinesterase (BuChE) activities. Material and Method: Thirty grams of each plant and 181 grams of the whole recipe were separately extracted by 95% ethanol, after filtered the filtrate were evaporated and vacuum-dried at 45°C. By Elman method, the inhibitory activities of both enzymes were assessed. The volatile constituents of each extract were determined by GCMS. The constituents in the nonvolatile extract were examined by TLC and the antioxidant activity was determined. Results: Four plants exhibited specific BuChE inhibitor were Lepidium sativum Linn. (Ls), Piper nigrum L. (Pn), Angelica dahurica Benth (Ad) and Atractylodes lancea DC. (Al), which shown the IC50 of 5.59, 24.52, 73.23, 96.25 μg/ml, respectively whereas galantamine and the whole recipe showed IC50 of 0.59 and 236 μg/ml. Only Pn extract inhibited AChE at IC50 of 25.46 μg/ml. By GCMS and TLC fingerprints revealed the main constituents in LS, Ad, Al and Pn as apiol, cumialdehyde, furanodiene and piperine. Moreover, nine plant extracts and the whole recipe showed antioxidant activity. Conclusion: Lepidium sativum Linn. (Ls) extract showed the most potency on BuChE inhibitory effect. Three ingredients and the whole recipe exhibited mild activity. Only Piper nigrum L demonstrated inhibition effect on both AChE and BuChE. Keywords: Cholinesterase inhibitor, Apai-sa-le recipe

Published
2014

39. Potentiation of doxorubicin (DXR)'s genotoxic activities by ethanolic extract from Thai Plumbago indica roots (EEPIR) in human lymphocytes in vitro

Author

Intouch Sakpakdeejaroen, T Ratanavalachai, Arunporn Itharat, S Thitiorul, and S Tanuchit

Subjects
Pharmacology, Plumbago indica, biology, Traditional medicine, business.industry, Organic Chemistry, Pharmaceutical Science, Long-term potentiation, biology.organism_classification, In vitro, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Molecular Medicine, Medicine, Doxorubicin, business, medicine.drug
Published
2014

42. In vitro cytotoxic activity of Derris scandens stem extracts against lung cancer cells and their anti-oxidant and anti-microbial effects

Author

Arunporn Itharat, N Prommee, and O Prajuabjinda

Subjects
Pharmacology, Traditional medicine, business.industry, Derris scandens, Organic Chemistry, Pharmaceutical Science, Anti oxidant, medicine.disease, Antimicrobial, In vitro, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, Immunology, medicine, Molecular Medicine, Cytotoxic T cell, Lung cancer, business
Published
2013

43. Anti-inflammatory, anti-bacterial and antioxidant activities of Thai medicinal plants for diarrheal treatment

Author

P Suthon, Sumalee Panthong, N Jaiarree, and Arunporn Itharat

Subjects
Pharmacology, Antioxidant, Traditional medicine, business.industry, medicine.drug_class, medicine.medical_treatment, Organic Chemistry, Pharmaceutical Science, Anti-inflammatory, Analytical Chemistry, Complementary and alternative medicine, Drug Discovery, medicine, Molecular Medicine, Anti bacterial, business, Medicinal plants
Published
2013

44. Anti-cholinesterase activity of 5-Theins recipes potentially used for Alzheimer's disease

Author

P Akkapinya, Arunporn Itharat, and C Sattaponpan

Subjects
Pharmacology, Gerontology, medicine.medical_specialty, biology, business.industry, Organic Chemistry, Pharmaceutical Science, Disease, Analytical Chemistry, Complementary and alternative medicine, Internal medicine, Drug Discovery, biology.protein, Molecular Medicine, Medicine, business, Cholinesterase
Published
2013

46. Growth arrest and Apoptosis of Dioscoreanone from Dioscorea membranacea against Human non-small cell lung cancer A549 cells

Author

Pintusorn Hansakul, Kalaya Aree, and Arunporn Itharat

Subjects
Pharmacology, A549 cell, Organic Chemistry, Pharmaceutical Science, Biology, medicine.disease, Analytical Chemistry, Dioscoreanone, Complementary and alternative medicine, Apoptosis, Growth arrest, Drug Discovery, Immunology, Cancer research, medicine, Molecular Medicine, Non small cell, Lung cancer, Dioscorea membranacea
Published
2013

47. PEG2 inhibitory compounds from Dioscorea membranacea roots

Author

Srisopa Ruangnoo, Arunporn Itharat, and P Thongdeeying

Subjects
Pharmacology, Complementary and alternative medicine, Organic Chemistry, Drug Discovery, Botany, Pharmaceutical Science, Molecular Medicine, Biology, Inhibitory postsynaptic potential, Dioscorea membranacea, Analytical Chemistry
Published
2013

50. Immunomodulatory activity of Dioscorea membranacea Pierre and its compound

Author

B Sriwatthana, Arunporn Itharat, P Thongdeeying, Sumalee Panthong, and S. Reuangnoo

Subjects
Pharmacology, Complementary and alternative medicine, Traditional medicine, Organic Chemistry, Drug Discovery, Botany, Pharmaceutical Science, Molecular Medicine, Biology, Dioscorea membranacea, Analytical Chemistry
Published
2013

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