1. High Serum Fractalkine is Associated with Lower Trabecular Bone Score in Premenopausal Women with Graves’ Disease
- Author
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Dusan Pavai, Zdenko Killinger, Pavel Blažíček, Peter Vaňuga, Peter Jackuliak, Juraj Payer, Zuzana Kužmová, Martin Kužma, Neil Binkley, Anton Vaňuga, and Ivana Ságová
- Subjects
Adult ,0301 basic medicine ,Thyroid Hormones ,medicine.medical_specialty ,Chemokine ,Bone density ,Endocrinology, Diabetes and Metabolism ,Graves' disease ,Clinical Biochemistry ,030209 endocrinology & metabolism ,Biochemistry ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Trabecular bone score ,Bone Density ,Internal medicine ,Humans ,Medicine ,CX3CL1 ,biology ,Chemokine CX3CL1 ,business.industry ,Biochemistry (medical) ,Thyroid ,General Medicine ,medicine.disease ,Graves Disease ,Peptide Fragments ,Procollagen peptidase ,Cross-Sectional Studies ,030104 developmental biology ,medicine.anatomical_structure ,Premenopause ,Cancellous Bone ,biology.protein ,Female ,business ,Biomarkers ,Procollagen - Abstract
Chemokine CX3CL1 (fractalkine) may be an important factor linking thyroid status and bone remodeling, through tetrac, a derivative of thyroxine. This study explores the relationship between serum fractalkine levels and parameters of thyroid status and bone in premenopausal women with Graves’ disease (GD) in comparison to healthy controls. This cross-sectional study included three premenopausal female groups: active GD; cured GD, and healthy age-, gender-, and BMI-matched controls. Measurement of serum fractalkine levels (Quantikine® ELISA), total amino-terminal peptide of procollagen type 1 (P1NP), CTx, thyroid hormones, BMD and trabecular bone score (TBS) were performed in all study subjects. Sixty women (21, 16, and 23 in active GD, cured GD, and healthy control groups, respectively) were included. Serum fractalkine levels were higher (p
- Published
- 2018
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