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2 results on '"Jinyong Liu"'

1. Dimethylaminomethylphosphonic Acid Derivatives-Promoted CuI-Catalyzed Synthesis of Aryl Ethers

Author

Ying Jin, Yufen Zhao, Hua Fu, Jinyong Liu, Yuyang Jiang, and Yingwu Yin

Subjects
Solvent, chemistry.chemical_classification, chemistry.chemical_compound, Base (chemistry), Chemistry, Aryl, Organic Chemistry, Ether, Medicinal chemistry, Toluene, Coupling reaction, Catalysis, Ullmann reaction
Abstract

An inexpensive and efficient catalyst system for synthesis of aryl ethers has been developed by using 20 mol% Cul as the catalyst, 30 mol% dimethylaminomethylphosphonic acid derivatives as the new ligands, K 2 CO 3 as the base and toluene as the solvent. This is the first example using aminophosphonates as the ligands for Ullmann ether coupling reaction.

Published
2006

2. New and Efficient Approach to Aryl Phosphoramidate Derivatives of AZT/d4T as Anti-HIV Prodrugs

Author

Jinyong Liu, Xueshu Li, Hua Fu, Yufen Zhao, and Yuyang Jiang

Subjects
chemistry.chemical_classification, Anti hiv, viruses, Aryl, Organic Chemistry, virus diseases, Phosphoramidate, biochemical phenomena, metabolism, and nutrition, Prodrug, Combinatorial chemistry, Amino acid, chemistry.chemical_compound, chemistry, parasitic diseases, Organic chemistry, heterocyclic compounds, Phosphoramide, Triethylamine, Hexachloroethane
Abstract

Ester exchange of diaryl phosphite with AZT or d4T produced aryl AZT/d4T H-phosphonate, and the following reaction with amino acid esters in the presence of hexachloroethane and triethylamine yielded membrane-soluble anti-HIV prodrugs aryl phosphoramide derivatives of AZT and d4T in good yields.

Published
2004

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