Search

The combination of enzymes and metal complexes can be used to achieve the de-epimerization of diastereoisomeric mixtures. Thus, by means of this chemoenzymatic dynamic kinetic asymmetric transformation (DYKAT), a wide range of racemic diols and, to a lesser extent, amino alcohols and diamines, have been transformed into a single diastereoisomer in excellent yields, and diastereo- and enantioselectivities.