1. Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
- Author
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Valdis Pirags, Ineta Kalnina, Raitis Peculis, Liene Nikitina-Zake, K. Geldnere, Davids Fridmanis, L. Tarasova, and Janis Klovins
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Male ,endocrine system ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Population ,Single-nucleotide polymorphism ,Type 2 diabetes ,Biology ,Polymorphism, Single Nucleotide ,Body Mass Index ,Endocrinology ,Polymorphism (computer science) ,Databases, Genetic ,Genetic model ,Internal Medicine ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,Obesity ,education ,Genetic Association Studies ,Genetics ,education.field_of_study ,nutritional and metabolic diseases ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Latvia ,Diabetes Mellitus, Type 2 ,Case-Control Studies ,Female ,Transcription Factor 7-Like 2 Protein ,TCF7L2 - Abstract
Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for type 2 diabetes (T2D) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. We genotyped 4 single nucleotide polymorphisms (SNP) rs7901695, rs7903146, rs11196205 and rs12255372 in 1 093 controls and 1 043 diabetic subjects. Association with T2D was found for 3 SNPs rs7901695, rs7903146 and rs12255372 in the whole sample (under an additive genetic model, the adjusted odds ratios (OR) were 1.26, 95% CI [1.08-1.48], P=0.003; OR=1.32, 95% CI [1.12-1.55], P=0.001 and OR=1.35, 95% CI [1.15-1.60], P=0.0004 respectively). In addition observed effects on T2D susceptibility for analysed SNPs were higher among subjects with BMI under 30 kg/m². The impact of TCF7L2 variation on T2D risk in Latvian population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.
- Published
- 2012
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