1. Stereoselective Domino Reactions in the Synthesis of Spiro Compounds
- Author
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Sandro J. Greco, Maurizio Benaglia, Regina Westphal, Eclair Venturini Filho, and Fabrizio Medici
- Subjects
Organic Chemistry ,Catalysis - Abstract
This review summarizes the latest developments in asymmetric domino reactions, with the emphasis on the preparation of spiro compounds. Discussions on the stereoselectivity of the transformations, the reaction mechanisms, the rationalization of the stereochemical outcome, and the applications of domino reactions to the synthesis of biologically active molecules and natural products are included when appropriate.1 Introduction2 Asymmetric Domino Reactions2.1 Domino Reactions Initiated by Michael Reactions2.2 Domino Reactions Initiated by Mannich Reactions2.3 Domino Reactions Initiated by Knoevenagel Reactions2.4 Domino Reactions Initiated by Cycloaddition Reactions2.5 Domino Reactions Initiated by Metal Insertion2.6 Other Mechanisms3 Conclusion
- Published
- 2022
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