1. The Fetomaternal Dependency of Cord Blood Interleukin-6
- Author
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René Heylen, R F De Jongh, M. J. Puylaert, E. Bosmans, Willem Ombelet, and Marie-Berthe Maes
- Subjects
medicine.medical_specialty ,medicine.medical_treatment ,Passive immunity ,Umbilical cord ,Pregnancy ,Anesthesia, Obstetrical ,Humans ,Medicine ,Fetus ,Cesarean Section ,Interleukin-6 ,business.industry ,Obstetrics ,Infant, Newborn ,Acute-phase protein ,Obstetrics and Gynecology ,Delivery, Obstetric ,Fetal Blood ,medicine.disease ,Hematopoiesis ,Parity ,medicine.anatomical_structure ,Cord blood ,Pediatrics, Perinatology and Child Health ,Apgar Score ,Analgesia, Obstetrical ,Gestation ,Female ,Apgar score ,business ,Biomarkers ,Gravitation - Abstract
Interleukin-6 (IL-6) plays a major role in hematopoiesis, immune functioning, and the acute phase response. In umbilical cord blood, this cytokine was thought to be a marker of neonatal defense to stress and infection, however, neonatal IL-6 production is immature. We speculated that a maternal influence exists on neonatal IL-6, at least during uncomplicated deliveries. Of the 81 healthy parturients included in this study, 51 delivered vaginally, 20 with and 31 without epidural analgesia, and 30 underwent elective cesarean section, 20 with epidural and 10 with general anesthesia. Maternal blood was sampled on hospital admission and just after delivery. Neonatal blood was collected from the umbilical cord. A significant positive correlation was found between neonatal cord blood interleukin-6 levels and maternal serum IL-6 levels on admission (r = 0.57, p
- Published
- 1999
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