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Your search keyword '"Safdar Hayat"' showing total 2 results
Start Over Author "Safdar Hayat" Publisher georg thieme verlag kg
2 results on '"Safdar Hayat"'

1. Syntheses, Antibacterial, Cytotoxic and Antifungal Effects of New 3-Carboxy-1-phenacylpyridinium Salts

Author

Khalid Mohammed Khan, Safdar Hayat, Muhammad Abbas, Muhammad Saeed, Wolfgang Voelter, Zafar Saeed Saify, Syed Tasadaque Ali Shah, and Mansoor Ahmed

Subjects
chemistry.chemical_classification, Pyridinium Compounds, biology, Chemistry, Carboxylic acid, Brine shrimp, biology.organism_classification, Phenacyl, chemistry.chemical_compound, Drug Discovery, Bioassay, Organic chemistry, Acid salt, Cytotoxicity, Antibacterial agent
Abstract

Thirteen pyridine-3-carboxylic acid salt derivatives with various substituted phenacyl residues were prepared and their cytotoxicity, antibacterial and antifungal activities tested. Compounds 5 and 11 proved to be active in the brine shrimp bioassay, compounds 7, 9-12 and 14 showed promising antibacterial activities, whereas none of the compounds tested against 15 fungal cultures proved to be active. Extensive spectroscopic techniques were employed to confirm the structure of the synthetic products.

Published
2011
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2. Synthesis and Biological Evaluation of Isomeric Derivatives of Naturally Occurring Spatozoate

Author

Wolfgang Voelter, Syed Tasadaque Ali Shah, Atta-ur-Rahman, Safdar Hayat, Awais Anwar, Khalid Mohammed Khan, Ernst Bayer, Shagufta Perveen, M. I. Choudhary, and Muhammad Usman Anwar

Subjects
Antifungal Agents, Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, medicine.drug_class, Antibiotics, Antineoplastic Agents, Microbial Sensitivity Tests, Phaeophyta, Median lethal dose, Mass Spectrometry, Broad spectrum, chemistry.chemical_compound, Drug Discovery, Benzene Derivatives, medicine, Animals, Organic chemistry, Microsporum canis, Cytotoxicity, Biological evaluation, Bacteria, biology, Chemistry, Fungi, Phthalate, biology.organism_classification, Anti-Bacterial Agents, Indicators and Reagents, Spectrophotometry, Ultraviolet, Spatozoate, Artemia, Drug Screening Assays, Antitumor
Abstract

An isomer of the natural phthalate ester spatozoate (1), n-butyl 2-benzoyloxymethylbenzoate (2a) and a series of its new derivatives 2b–2s were synthesized and exposed to selected biological screening, as phthalates were reported to possess different biological activities. Compound 2g was found to be the most potent cytotoxic agent with a LD 50 = 8.98 µg/ml. In a bactericidal assay the compounds showed a broad spectrum of activities. Compound 2a has a very promising fungicidal activity against Microsporum canis .

Published
2011
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