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Mental disorders contribute significantly to the global burden of diseases. Projections towards the year 2020 show that the neuropsychiatric illness will increase their share from about 10.5% of the total burden of disease in 1990 to 15% in 2020 [1]. Mentha arvensis is an indigenous plant of the Lamiaceae family commonly known as ‘Pudina’ and ‘Mint’ in English. It is reported to exhibit central nervous system (CNS) modulating effects [2]. Hence, the present study was carried out to investigate aqueous and methanol extracts of Mentha arvensis Linn extracts for antioxidant and antidepressant activity. Aqueous and methanol extracts of Mentha arvensis were preliminary studied for in vitro antioxidant activity using 1, 1-Diphenyl-2-Picrylhydrazyl (DPPH), Nitric oxide and Hydroxyl radical scavenging activity methods. Then the extracts were investigated for antidepressant activity by Tail suspension and Forced swim test at dose level of 125, 250 and 500mg/kg in Swiss albino mice. Fluoxetin was used as a positive control at the dose of 10mg/kg. Methanol extract showed significant antioxidant and antidepressant activity as compared to aqueous extract. However, there is need for further studies to evaluate its mode of action. References: 1. Kastrup M, et al (2007) Dan. Med. Bull 54: 42–432. 2. Pia M. Vuorela et al.(2006) Fitoterapia 77:429–434.