1. Cycloartane and Oleanane Saponins from EgyptianAstragalusspp. as Modulators of Lymphocyte Proliferation
- Author
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Aya M. Assad, Mohamed M. Radwan, Soad M. Toaima, Ying-De Luo, Nadia A. El-Sebakhy, Luisella Verotta, Marco Guerrini, and John M. Pezzuto
- Subjects
Magnetic Resonance Spectroscopy ,Saponin ,Pharmaceutical Science ,Mice, Inbred Strains ,Lymphocyte proliferation ,Pharmacognosy ,Plant Roots ,Analytical Chemistry ,Mice ,chemistry.chemical_compound ,Astragaloside ,Adjuvants, Immunologic ,Drug Discovery ,Tumor Cells, Cultured ,Animals ,Humans ,Cytotoxic T cell ,Cycloastragenol ,Lymphocytes ,Oleanolic Acid ,Oleanane ,Pharmacology ,chemistry.chemical_classification ,Dose-Response Relationship, Drug ,Traditional medicine ,Plant Extracts ,Organic Chemistry ,Astragalus Plant ,Saponins ,Triterpenes ,In vitro ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Egypt ,Medicine, Traditional ,Phytotherapy - Abstract
From the roots of Astragalus kahiricus DC., three known saponins, namely, astraversianin VI, astraversianin X, astragaloside VIII, and a new saponin were isolated and identified by spectral data. The structure of the latter was elucidated by spectral means and assigned as cycloastragenol 3- O-[ beta- D-(2',3'-diacetyl, 4'- trans-2-butenoyl)-xylopyranosyl], 6- O- beta- D-xylopyranoside (kahiricoside I). From the aerial parts of A. hamosus L., the known compounds azukisaponin V and peregrinoside I were isolated. As judged by in vitro tests, the saponins isolated from Astragalus spp. endemic to Egypt were not cytotoxic against a variety of human cancer cells. However, dose-related modulation of lymphocyte proliferation was observed, and structure-activity relationships are described.
- Published
- 2002
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