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Start Over Author "Xu, Yibo" Topic column chromatography Publisher georg thieme verlag stuttgart
1 results on '"Xu, Yibo"'

1. An Improved Scalable Process for the Synthesis of (S , S)-DACH-Ph Trost Ligand.

Author

Zhang, Yongda, Chong, Eugene, White, Jada A. H., Radomkit, Suttipol, Xu, Yibo, Kosnik, Stephanie C., and Lorenz, Jon C.

Subjects
CHEMICAL processes, COLUMN chromatography, AMIDATION
Abstract

An improved chemical process has been developed for the synthesis of (S , S)-DACH-Ph Trost ligand. The amidation of 2-diphenylphosphinylbenzoic acid and (S , S)-diaminocyclohexane is promoted by stoichiometric CDI and catalytic imidazole hydrochloride. The resulting product, (S , S)-DACH-Ph Trost ligand, is isolated as a white solid in 80% yield with >99% ee by simple filtration without column chromatography. The current facile process is also demonstrated on kilogram scale. [ABSTRACT FROM AUTHOR]

Published
2022
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