1. Sesquiterpenes from the Roots of Illicium jiadifengpi.
- Author
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Guijie Zhang, Pengyu Zhuang, Xiaojing Wang, Shishan Yu, Shuanggang Ma, Jing Qu, Yong Li, Yunbao Liu, Yan Zhang, and Dequan Yu
- Subjects
CHROMATOGRAPHIC analysis ,BIOLOGICAL assay ,CAMPTOTHECIN ,CELL culture ,CRYSTALLOGRAPHY ,MASS spectrometry ,MOLECULAR structure ,NUCLEAR magnetic resonance spectroscopy ,PHARMACEUTICAL chemistry ,RESEARCH funding ,RIBAVIRIN ,PLANT roots ,TERPENES ,TOXICITY testing - Abstract
Two new sesquiterpenes (1, 2) and two new sesquiterpene glycosides (3, 4) with a seco-prezizaane skeleton, three new allo-cedrane sesquiterpene glycosides (5-7), and a new acorane sesquiterpene (8) as well as 15 known analogues were isolated from the roots of Illicium jiadifengpi used for the treatment of rheumatoid arthritis. The structures of these compounds were elucidated by extensive spectroscopic analysis and chemical methods. The absolute configurations of compounds 5-7 were confirmed by CD experiments. The configuration of compound 8 was assigned by single-crystal X-ray crystallographic analysis and CD experiments. Compounds 4, 6, 7, 14, and 23 showed moderate antiviral activities against Coxsackie virus B3, and all compounds were inactive when evaluated for their cytotoxic activities against five human tumor cell lines and neuroprotection. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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