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This article explores the impact of chromosome copy number thresholds on the molecular classification of meningioma, a type of brain tumor. The study analyzes data from 1,042 patients who underwent surgery for meningioma and examines the relationship between chromosome arm copy number variants (CNVs) and tumor behavior. The researchers find significant variability in the fraction of chromosomes lost or gained in meningiomas, with certain chromosomes showing higher rates of loss or gain. They also observe that altering CNV thresholds can affect the molecular classification of meningiomas and potentially impact predictions of tumor recurrence. The study highlights the importance of determining optimal CNV call thresholds to ensure accurate and reproducible molecular classification of meningiomas. [Extracted from the article]