Kijjoa, Anake, Gonzalez, Maria Jose, Pinto, Madalena M., Nascimento, Maria S�o, Campos, Nair, Mondranondra, Ing-On, Silva, Artur M.S., Eaton, Graham, and Herz, Werner
One new prenylated xanthone 5-farnesyltoxyloxanthone B (4), three known xanthones α-mangostin (1), rubraxanthone (2) and isocowanol (3) as well as (2E,6E,10E)-4β-hydroxy-3-methyl-5β-(3,7,11,15-tetramethylhexadeca-2,6,10-tetraenyl)-cyclohex-2-en-1-one (5) and 3,3′,4-O-trimethylellagic acid were isolated from the wood of Garcinia merguensis Wight. The cytotoxic activities of compounds 1 – 5 were evaluated against the MCF-7, MDA-MB-231, NCI-H-460 and SF-268 cell lines with rubraxanthone 2 and 5 exhibiting the highest activity at 9.0 and 12.1 μM, respectively, against MCF-7 cells. [ABSTRACT FROM AUTHOR]