1. Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata.
- Author
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Zhang, Bao-Jun, Fu, Wen-Wei, Wu, Rong, Yang, Jin-Ling, Yao, Cai-Yun, Yan, Bing-Xiong, Tan, Hong-Sheng, Zheng, Chang-Wu, Song, Zhi-Jun, and Xu, Hong-Xi
- Subjects
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BIOLOGICAL assay , *CELL lines , *CELL physiology , *HETEROCYCLIC compounds , *LEAVES , *MASS spectrometry , *MEDICINAL plants , *MOLECULAR structure , *NUCLEAR magnetic resonance spectroscopy , *PLANT extracts , *CYTOTOXINS - Abstract
Six new prenylated xanthones (1 – 6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15 – 17 showed moderate inhibitory effects on tumor cell growth, with IC50 s ranging from 3.7 to 14.7 µM. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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