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Objective: Protein phosphatases, e.g., PTP1B, are crucial for regulating the activity of protein tyrosine kinases, e.g., the EGFR. Since most EGFR targeted therapies did not show a significant increase in progression-free survival and overall survival, novel ways of inhibiting tumor-promoting pathways, [for full text, please go to the a.m. URL]

Objective: Despite ongoing research, glioblastoma (GBM) still has a poor prognosis even under standard therapy, combining surgery, temozolomide (TMZ) and irradiation (Rx). It was demonstrated before that the dipeptide carnosine (β-alanyl-L-histidine; Car) not only reduces growth, migration and[for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Objective: Carnosine, a dipeptide composed of beta-alanine and L-histidine has anti-neoplastic effects as demonstrated in different tumor models including glioblastoma cell culture. Although its molecular targets are unknown, it has been demonstrated that carnosine induces mRNA expression of pyruvate[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Despite ongoing research efforts, glioblastoma (GBM) still has a poor prognosis even under standard therapy, combining temozolomide (Tmz) and irradiation (Rx). Here, we investigated whether the dipeptide carnosine (β-alanine-L-histidine; Car), which reduces growth, migration and metastasis[for full text, please go to the a.m. URL], 69. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Mexikanischen und Kolumbianischen Gesellschaft für Neurochirurgie

Objective: Tumor cell metabolism is dependent on the conversion of glucose to lactate even under aerobic conditions. This phenomenon, first described by Otto Warburg, is known as aerobic glycolysis and has been discussed as a possible Achilles heel for decades. After the discovery that the naturally[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Objective: Carnosine (beta-alanyl-L-histidine) is a naturally occurring dipeptide that exhibits anti-neoplastic effects in cell cultures derived from glioblastoma (GBM) as well as in animal models. Previous studies indicated that the anti-proliferative effect of carnosine is accompanied by a reduction[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)