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The article presents a letter of instruction written by United States President Thomas Jefferson to Meriwether Lewis, captain of the 1st Regiment of Infantry of the United States of America. Jefferson details the equipment and supplies to be provided to Lewis on his mission, including mapping equipment, men, boats, ammunition, and medical supplies. Jefferson says that Lewis's mission has been communicated to the Ministers of France, Spain, and Great Britain, who have agreed to let Lewis pass through their territories outside the U.S. The mission, Jefferson explains, is to explore the Missouri river to see if it leads to the Pacific Ocean in any way, in the hopes of finding the most direct and practical way across the continent by water, for the purpose of commerce.

Presents the confidential message which the United States president sent to Congress about his plans for an expedition he sent across the continent to the Pacific Ocean. Background of relations with the Indian tribes dwelling with the United States' borders; Importance of bringing civilization to the Indians; How an expedition would be set up and financed; Importance of extending the nation's borders, especially along the Mississippi River.