1. Immunoexpression of SPANX-C in metastatic uveal melanoma.
- Author
-
Salvatorelli L, Puzzo L, Russo A, Reibaldi M, Longo A, Ragusa M, Aldo C, Rappazzo G, Caltabiano R, and Salemi M
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Humans, Immunohistochemistry, Liver Neoplasms secondary, Male, Melanoma secondary, Middle Aged, Prognosis, Uveal Neoplasms pathology, Liver Neoplasms metabolism, Melanoma metabolism, Neoplasm Proteins metabolism, Uveal Neoplasms metabolism
- Abstract
Uveal melanoma is a rare disease but it is the most common primary intraocular malignant tumor in adults with poor late prognosis. About 50% of patients will develop liver metastasis far from the enucleation within 10-15 years. Our study examined SPANX-C expression levels in primary uveal melanoma both with and without metastasis to assess if they can be used to predict metastasis. This study included a total of 55 patients, 28 males and 27 females, with uveal melanoma. A significantly high expression of SPANX-C was seen in 19/23 (82.6%) patients with metastasis, and only in 11/32 (38.5%) patients without metastasis. In conclusion, we found that SPANX-C expression could play a role in tumor progression of uveal melanoma., (Copyright © 2019. Published by Elsevier GmbH.)
- Published
- 2019
- Full Text
- View/download PDF