1. Origin and Global Expansion of Mycobacterium tuberculosis Complex Lineage 3
- Author
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Yassir A. Shuaib, Christian Utpatel, Thomas A. Kohl, Ivan Barilar, Margo Diricks, Nadia Ashraf, Lothar H. Wieler, Glennah Kerubo, Eyob A. Mesfin, Awa Ba Diallo, Sahal Al-Hajoj, Perpetua Ndung’u, Margaret M. Fitzgibbon, Farzam Vaziri, Vitali Sintchenko, Elena Martinez, Sofia O. Viegas, Yang Zhou, Aya Azmy, Khaled Al-Amry, Sylvain Godreuil, Mandira Varma-Basil, Anshika Narang, Solomon Ali, Patrick Beckert, Viola Dreyer, Mwila Kabwe, Matthew Bates, Michael Hoelscher, Andrea Rachow, Andrea Gori, Emmanuel M. Tekwu, Larissa K. Sidze, Assam A. Jean-Paul, Veronique P. Beng, Francine Ntoumi, Matthias Frank, Aissatou Gaye Diallo, Souleymane Mboup, Belay Tessema, Dereje Beyene, Sadiq N. Khan, Roland Diel, Philip Supply, Florian P. Maurer, Harald Hoffmann, Stefan Niemann, Matthias Merker, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), and Supply, Philip
- Subjects
Mycobacterium tuberculosis ,MTBC ,Lineage 3 ,back to Africa ,[SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] ,[SDV.GEN.GPO] Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE] ,Genetics ,[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Genetics (clinical) ,Uncategorized - Abstract
International audience; Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest tuberculosis burden. To investigate the population structure and the global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 strains from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number of tandem repeats genotyping (MIRU-VNTR) and drug susceptibility testing. We further combined whole-genome sequencing (WGS) and phylogeographic analysis for 373 strains representing the global L3 genetic diversity. Ancestral state reconstruction confirmed that the origin of L3 strains is located in Southern Asia and further revealed multiple independent introduction events into North-East and East Africa. This study provides a systematic understanding of the global diversity of L3 strains and reports phylogenetic variations that could inform clinical trials which evaluate the effectivity of new drugs/regimens or vaccine candidates.
- Published
- 2022
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