1. Broadband time-resolved multi-channel functional near-infrared spectroscopy system to monitor in vivo physiological changes of human brain activity
- Author
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Françoise Peyrin, Frédéric Lange, Bruno Montcel, RMN et optique : De la mesure au biomarqueur, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), European Synchrotron Radiation Facility (ESRF), and Imagerie Tomographique et Radiothérapie
- Subjects
Adult ,Male ,Point spread function ,Haemodynamic response ,Computer science ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,Spectrometers and spectroscopic instrumentation ,Imaging spectrometer ,01 natural sciences ,law.invention ,010309 optics ,Hemoglobins ,03 medical and health sciences ,0302 clinical medicine ,Optics ,law ,0103 physical sciences ,Medical optics instrumentation ,medicine ,Humans ,Electrical and Electronic Engineering ,Blood or tissue constituent monitoring ,Spectroscopy ,Engineering (miscellaneous) ,Brain Mapping ,Optical time domain reflectometry ,Spectroscopy, Near-Infrared ,business.industry ,Lasers ,Functional monitoring and imaging ,Hemodynamics ,Brain ,Human brain ,Laser ,Atomic and Molecular Physics, and Optics ,Supercontinuum ,medicine.anatomical_structure ,Time-resolved imaging ,Functional near-infrared spectroscopy ,business ,030217 neurology & neurosurgery - Abstract
International audience; We have developed a broadband time-resolved multi-channel near-infrared spectroscopy system that can monitor the physiological responses of the adult human brain. This system is composed of a supercontinuum laser for the source part and of an intensified charge-coupled device camera coupled with an imaging spectrometer for the detection part. It allows the detection of the spectral, from 600 to 900 nm, and spatial dimensions as well as the arrival time of photon information simultaneously. We describe the setup and its characterization in terms of temporal instrument response function, wavelength sensitivity, and stability. The ability of the system to detect the hemodynamic response is then demonstrated. First, an in vivo experiment on an adult volunteer was performed to monitor the response in the arm during a cuff occlusion. Second, the response in the brain during a cognitive task was monitored on a group of five healthy volunteers. Moreover, looking at the response at different time windows, we could monitor the hemodynamic response in depth, enhancing the detection of the cortical activation. Those first results demonstrate the ability of our system to discriminate between the responses of superficial and deep tissues, addressing an important issue in functional near-infrared spectroscopy.
- Published
- 2018
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