1. Validation of a dose deposited by low-energy photons using GATE/GEANT4
- Author
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B. Habib, Vincent Breton, D. Donnarieix, Lydia Maigne, C. O. Thiam, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), and UNICANCER more...
- Subjects
Male ,Photon ,medicine.medical_treatment ,Brachytherapy ,Monte Carlo method ,Lambda ,030218 nuclear medicine & medical imaging ,Iodine Radioisotopes ,03 medical and health sciences ,0302 clinical medicine ,Spect imaging ,medicine ,Dosimetry ,Humans ,Radiology, Nuclear Medicine and imaging ,Computer Simulation ,Radionuclide Imaging ,Simulation ,Physics ,Photons ,Radiological and Ultrasound Technology ,Prostatic Neoplasms ,Function (mathematics) ,3. Good health ,Computational physics ,030220 oncology & carcinogenesis ,[PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph] ,Anisotropy ,Tomography ,Monte Carlo Method - Abstract
The GATE Monte Carlo simulation platform based on the Geant4 toolkit has now become a diffused tool for simulating PET and SPECT imaging devices. In this paper, we explore its relevance for dosimetry of low-energy 125I photon brachytherapy sources used to treat prostate cancers. To that end, three 125-iodine sources widely used in prostate cancer brachytherapy treatment have been modelled. GATE simulations reproducing dosimetric reference observables such as radial dose function g(r), anisotropy function F(r, theta) and dose-rate constant (Lambda) were performed in liquid water. The calculations were splitted on the EGEE grid infrastructure to reduce the computing time of the simulations. The results were compared to other relevant Monte Carlo results and to measurements published and fixed as recommended values by the AAPM Task Group 43. GATE results agree with consensus values published by AAPM Task Group 43 with an accuracy better than 2%, demonstrating that GATE is a relevant tool for the study of the dose induced by low-energy photons. more...
- Published
- 2008
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