1. Magnetic resonance imaging of hypoxia in acute stroke: a cross‐validation study against FMISO‐positron emission tomography
- Author
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Samuel, Valable, Toutain, Jérôme, Divoux, Didier, Chazalviel, Laurent, Corroyer-Dulmont, Aurélien, Chakhoyan, Ararat, Guillouet, Stéphane, Bernaudin, Myriam, Barbier, Emmanuel, Touzani, Omar, Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Laboratoire de Développements Méthodologiques en Tomographie par Emission de Positons (LDM-TEP), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), and Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN)
- Subjects
hypoxia ,[SDV]Life Sciences [q-bio] ,tissue oxygenation ,FMISO-PET ,stroke ,MRI - Abstract
CERVOXY; International audience; Acute ischemic stroke results in ischemic core surrounded by a tissue at risk, named the penumbra, which is potentially salvageable. One way to differentiate the tissues is to measure the hypoxia status. The purpose of the study is to correlate the abnormal brain tissue volume derived from magnetic resonance-based imaging of brain oxygen saturation (StO2-MRI) to the [18F]FMISO positron emission tomography (PET) volume for hypoxia imaging validation, and to analyse the ability of StO2-MRI to depict the different hypoxic tissue types in the acute phase of stroke.In a pertinent model of stroke in the rat, the volume of tissue with decreased StO2-MRI signal and that with increased uptake of [18F]FMISO were equivalent and correlated (r=0.706; p=0.015). The values of StO2 in the tissue at risk were significantly greater than those quantified in the core of the lesion, and less than those of the healthy tissue (52.3±2.0%; 43.3±1.9% and 67.9±1.4%, respectively). A threshold value of StO2 of ≈60% as the cut-off for the identification of the tissue at risk was calculated. Tissue volumes with reduced StO2-MRI correlated with the final lesion (r=0.964, p
- Published
- 2023