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8 results on '"Dubanchet, S"'

1. The preconceptional environment affects the implantation process in a murine model of spontaneous abortion

Author

Chaouat, G., Coqué, Nathalie, Hennuy, B., Dubanchet, S., Rodde, Nathalie, Fleurot, Isabelle, Ledée, N., Sandra, Olivier, INSERM U782, Hôpital Antoine Béclère, Mathématiques et Informatique Appliquées (MIA-Paris), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, EMBIC, Lab Tumor Development, Centre Hospitalier Universitaire de Liège, Biologie du Développement et Reproduction (BDR), Institut National de la Recherche Agronomique (INRA), AgroParisTech-Institut National de la Recherche Agronomique (INRA), AP-HP - Hôpital Antoine Béclère [Clamart], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], IMPLANTATION FOETALE
Abstract

absent

Published
2008

2. Cytokine expression at interface : a longitudinal micro array

Author

Chaouat, G., Coqué, Nathalie, Hennuy, B., Dubanchet, S., Fleurot, Isabelle, Rodde, Nathalie, Ledée-Bataille, N., Sandra, Olivier, U782, Institut National de la Santé et de la Recherche Médicale (INSERM), Mathématiques et Informatique Appliquées (MIA-Paris), AgroParisTech-Institut National de la Recherche Agronomique (INRA), EMBIC, Tumor and Developement Laboratory, Université de Liège, Station de physiologie animale, Institut National de la Recherche Agronomique (INRA), Unité 782, UR 0888 Bactéries Lactiques et Pathogènes Opportunistes, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Département Microbiologie et Chaîne Alimentaire (MICA), Institut National de la Recherche Agronomique (INRA)-Bactéries Lactiques et Pathogènes Opportunistes (UBLO), and Biologie du Développement et Reproduction (BDR)

Subjects
reproduction, microarray, cytokineexpression, interface, network, méthode, CYTOKINE, biopuce, [SDV]Life Sciences [q-bio], réseau
Abstract

Main Session 3: Immuno-Endocrine Interactions in Reproduction.; absent

Published
2008
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3. Ovine progesterone-induced blocking factor at the feto-maternal interface during implantation

Author

Fovet, Claire Maëlle, Camous, Sylvaine, Poumerol, Elodie, Aubrière, Marie-Christine, Giraud-Delville, Corinne, Dahirel, Michèle, Nolent, F., Dubanchet, S., Szekeres-Bartho, J., Lea, R.G., Sandra, Olivier, ProdInra, Migration, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Unité 782, Institut National de la Santé et de la Recherche Médicale (INSERM), Pecs University Medical School, and University of Nottingham, UK (UON)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], PROGESTERONE, [INFO] Computer Science [cs], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

4. Th1/Th2 paradigm in pregnancy: paradigm lost? Cytokines in pregnancy/early abortion: Reexamining the Th1/Th2 paradigm

Author

Chaouat, G., Ledée-Bataille, N., Dubanchet, S., Zourbas, S., Sandra, Olivier, MARTAL, J., Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], [INFO]Computer Science [cs], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS, PLACENTA HUMAIN
Abstract

International audience

Published
2004

5. Reproductive immunology 2003: reassessing the Th1/Th2 paradigm ?

Author

Chaouat, G., Ledée-Bataille, N., Dubanchet, S., Zourbas, S., Sandra, Olivier, MARTAL, J., Biologie du développement et reproduction (BDR), and Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], RAT, [INFO]Computer Science [cs], IMMUNOLOGIE, CELLULEUSE TUEUSE
Abstract

57 ref.; International audience

Published
2004

6. A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy

Author

Chaouat, G., Zourbas, S., Ostojic, S., Lappree-Delage, G., Dubanchet, S., Ledée, N., MARTAL, J., Unité biologie du développement et biotechnologie, and École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA)

Subjects
[SDV]Life Sciences [q-bio], IMMUNOLOGIE, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2002

8. The mannose binding lectin pathway and early complement activation in (murine) abortion

Author

Nathalie Lédée, Olivier Sandra, Roberta Bulla, Gérard Chaouat, Marie Petitbarat, Sylvie Dubanchet, Francesco Tedesco, Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Università degli studi di Trieste, Biologie du développement et reproduction (BDR), Centre National de la Recherche Scientifique (CNRS)-École nationale vétérinaire d'Alfort (ENVA)-Institut National de la Recherche Agronomique (INRA), Petitbarat, M, Dubanchet, S, Bulla, Roberta, Sandra, O, Ledee, N, Tedesco, F, and Chaouat, G.

Subjects
[SDV]Life Sciences [q-bio], Immunology, 03 medical and health sciences, 0302 clinical medicine, C-type lectin, Immunology and Allergy, [INFO]Computer Science [cs], mouse, ComputingMilieux_MISCELLANEOUS, Mannan-binding lectin, 030219 obstetrics & reproductive medicine, mannose binding lectin, biology, Chemistry, GENETIQUE ANIMALE, CD69, Obstetrics and Gynecology, BIOLOGIE, mannose binding lectin, abortion, mouse, abortion, 3. Good health, Complement system, Reproductive Medicine, Biochemistry, Concanavalin A, Lectin pathway, biology.protein, Ficolin, MASP1, 030215 immunology
Abstract

Introduction: Girardi and Salmon highlighted the role of complement in early gestation failures in mice. We wanted to identify the pathway of its early activation in the murine natural immune resorbtion model she used. Methods: We monitored the protein and mRNAs expression of MBL-A and C, C3, at different days of gestation, in the uteri of either an “abortive murine combination” DBA/2-mated CBA/J females or a non abortive control mating and established MBL KO congenics on CBA/J background. Results: BALB/c-mated CBA/J females. We also comparatively quantified their expression by RT-PCR. The immunohistochemistry experiments revealed the presence of these (3) proteins and a differential expression of MBL-A between CBA/J × BALB/c and CBA/J × DBA/2 pregnancies while MBL-C was undetectable. However our results of RT-PCR revealed a very low or null local expression of MBL-A and C RNAs and no change in C3 RNA expression in the two combinations. We suggest that MBL-A, and C3 are produced elsewhere but activated locally. To verify the role of MBL, we established at INRA animal facility from breeders from Charles River Iffac Credo France on CBA/J background MBL-A, MBL-C, and MBL-A + C double congenics KO strain starting from MBL KO mice provided by Drs. Jensenius and Thiel Denmark. Albeit the results are still preliminary, at the 5th generation (96.88% of the genome of the KO is already CBA/J), our first results reveal a significant decrease of resorption (using chi-squared test with correction for small samples) in MBL-A KO CBA/J × DBA/2 compared with CBA/J × DBA/2 mating (4.3%, e.g. the incompressible rate of pregnancy loss due to chromosomal anomalies induced foetal demises in mice) versus 12.2% (the usual abortion rate seen in conventional but very clean breeding conditions as is the case at INRA). Depending on breeding and backcrosses, data at the 6th or 7th generation, and with more mice, will eventually be presented. Published data about MBL in human will also be discussed. Conclusions: These results reconcile the “danger” signals and the classical abortive cytokinic pathways, and have profound implications both in murine models and human clinics, which will also be discussed.

Published
2010
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