Search

Your search keyword '"Elisabeth Seguin ."' showing total 2 results
Start Over Author "Elisabeth Seguin ." Publisher hal ccsd
2 results on '"Elisabeth Seguin ."'

1. Antiradical Activity of Flavonoids from the Algerian Native Plant: Centaurea microcarpa Coss. et Dur

Author

Noureddine Gherraf, Hocine Laouer, Amar Zellagui, Séverine Derbré, Salah Akkal, Elisabeth Seguin, Kamel Medjroubi, S. Louaar, Laboratoire de Phytochimie et Analyses physicochimiques et Biologiques, Université Mentouri Constantine [Algérie] (UMC), Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Biology, Université Ferhat-Abbas Sétif 1 [Sétif] (UFAS1), and Département de Chimie

Subjects
Pharmacology, Antioxidant, biology, Chemistry, DPPH, medicine.medical_treatment, Plant Science, Native plant, Toxicology, biology.organism_classification, Agricultural and Biological Sciences (miscellaneous), [STAT]Statistics [stat], chemistry.chemical_compound, Complementary and alternative medicine, Phytochemical, Centaurea, Drug Discovery, Botany, medicine, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

A phytochemical investigation of the aerial parts of Centaurea microcarpa resulted in the isolation of two known flavonoids: 5,7,4′-trihydroxy-3,6-dimethoxyflavone 7-O-β-glucoside (1), 6- methoxykaempferol (2). The structures of these compounds were elucidated on the basis of 1D and 2D NMR and mass spectroscopy. Compounds: (1) and (2) were screened for their in vitro antioxidant activity through DPPH free radical-scavenging assay.

Published
2014
Full Text
View/download PDF

2. Erymildbraedin A and B, two novel cytotoxic dimethylpyrano-isoflavones from the stem bark of Erythrina mildbraedii: evaluation of their activity toward endocrine cancer cells

Author

Elisabeth Seguin, Ruben F. Tchokouaha, Elizabeth Chosson, Alexios-Leandros Skaltsounis, Jean Wandji, Xanthippi Alexi, Michael N. Alexis, Thierry Besson, Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, medicine.medical_specialty, Drug Evaluation, Preclinical, Breast Neoplasms, Adenocarcinoma, Biology, 01 natural sciences, law.invention, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, law, Cell Line, Tumor, Internal medicine, Drug Discovery, medicine, Plant Bark, Humans, Cytotoxic T cell, Erythrina, Cell Proliferation, 030304 developmental biology, Pharmacology, 0303 health sciences, Plant Stems, Traditional medicine, Plant Extracts, Cell growth, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Prostatic Neoplasms, General Medicine, Isoflavones, biology.organism_classification, Endometrial Neoplasms, 3. Good health, 0104 chemical sciences, Scoparone, 010404 medicinal & biomolecular chemistry, Endocrinology, chemistry, Cell culture, Female, Phytotherapy
Abstract

International audience; Two new dimethylpyrano-isoflavones, named erymildbraedin A (4) and B (5), were isolated from the stem bark of the Cameroonian medicinal plant Erythrina mildbraedii, along with four known ones, the linear congeners, scandenone (1), erysenegalinsein M (2), 5,4'-dihydroxy-2'-methoxy-8-(3,3-dimethylallyl)-2'',2''-dimethylpyrano[5,6:6,7]isoflavone (3), and the angular isoflavone eryvarin B (6), and two other compounds, fraxidin and scoparone. Their structures were elucidated by the usual spectroscopic methods and isoflavone effects on the growth of human breast, prostate, and endometrial adenocarcinoma cells were determined. Isoflavones 1, 3, and 6 strongly inhibited the growth of all three cell lines, supporting the notion that a non-oxidized isoprenyl group at C-8 is requisite for cytotoxic activity.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results