1. Altered balance between Th17 and Th1 cells at mucosal sites predicts AIDS progression in simian immunodeficiency virus-infected macaques
- Author
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Lorenzo Zaffiri, Maria Grazia Ferrari, John J. O'Shea, Monica Vaccari, Arian Laurence, R Washington Parks, Daniel C. Douek, David Venzon, Elzbieta Tryniszewska, Jean-Michel Heraud, Valentina Cecchinato, Wen-Po Tsai, Genoveffa Franchini, Christopher Trindade, Jason M. Brenchley, National Cancer Institute [Bethesda] (NCI-NIH), National Institutes of Health [Bethesda] (NIH), Animal Models and Retroviral Vaccines Section, National Institutes of Health [Bethesda] (NIH)-National Institutes of Health [Bethesda] (NIH), Molecular Immunology and Inflammation Branch, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), Advanced BioScience Laboratories Inc., Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Medical University of Bialystok, Biostatistics & Data Management Section, and This research was supported by the Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research.
- Subjects
CD4-Positive T-Lymphocytes ,MESH: Interleukin-17 ,Simian Acquired Immunodeficiency Syndrome ,medicine.disease_cause ,Virus Replication ,Interleukin 21 ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Immunology and Allergy ,MESH: Animals ,Lymphocytes ,Antigens, Viral ,0303 health sciences ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Interleukin-17 ,Interleukin ,MESH: CD4-Positive T-Lymphocytes ,Acquired immune system ,3. Good health ,[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology ,Interleukin 12 ,Simian Immunodeficiency Virus ,MESH: Simian Acquired Immunodeficiency Syndrome ,MESH: Antigens, Viral ,Immunology ,MESH: Simian Immunodeficiency Virus ,Biology ,Virus ,Article ,MESH: Macaca mulatta ,03 medical and health sciences ,Antigen ,medicine ,Animals ,Humans ,030304 developmental biology ,Mucous Membrane ,MESH: Humans ,MESH: Virus Replication ,MESH: Mucous Membrane ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,Simian immunodeficiency virus ,Th1 Cells ,Virology ,Macaca mulatta ,In vitro ,MESH: Th1 Cells ,MESH: Lymphocytes ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,030215 immunology - Abstract
International audience; Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower frequency at mucosal and systemic sites within a few weeks from infection. In highly viremic animals, Th1 cells predominates over Th17 T cells and the frequency of Th17 cells at mucosal sites is negatively correlated with plasma virus level. Because Th17 cells play a central role in innate and adaptive immune response to extracellular bacteria, our finding may explain the chronic enteropathy in human immunodeficiency virus (HIV) infection. Thus, therapeutic approaches that reconstitute an adequate balance between Th1 and Th17 may be beneficial in the treatment of HIV infection.
- Published
- 2008
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