Search

Your search keyword '"Eric Watier"' showing total 24 results
Start Over Author "Eric Watier" Publisher hal ccsd
24 results on '"Eric Watier"'

1. Abdominoplasty and lower body lift surgery improves the quality of life after massive weight loss: a prospective multicenter study

Author

Yanis Berkane, François Saget, Elise Lupon, Camille Mocquard, Isabelle Pluvy, Eric Watier, Alexandre G. Lellouch, Jérôme Duisit, Benoit Chaput, Nicolas Bertheuil, Massachusetts General Hospital [Boston, MA, USA], Harvard Medical School [Boston] (HMS), Hôpital Sud [CHU Rennes], CHU Pontchaillou [Rennes], Hôpital Pasteur [Nice] (CHU), Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)

Subjects
[SDV]Life Sciences [q-bio], Surgery
Abstract

International audience; BACKGROUND: This study was conducted to assess the impact of abdominoplasty and lower body lift surgery following massive weight loss on both the general quality of life and the sexual life of patients. METHODS: We performed a multicenter prospective study on the quality of life after massive weight loss using three scoring questionnaires: The Short Form 36 questionnaire, the Female Sexual Function Index questionnaire, and the Moorehead-Ardelt Quality of Life Questionnaire. Seventy-two patients who underwent lower body lift and 57 patients who underwent abdominoplasty in three centers with pre and post-operative evaluation were included. RESULTS: The mean age of the patients was 43.2 ± 13.2 years. All categories of the SF36 questionnaire were statistically significant at 6 months, and all categories except health change were significantly improved at 12 months post-operative. Overall, the Moorehead-Ardelt questionnaire showed a higher quality of life in general (1.78 ± 0.92 and 1.64 ± 1.03, at 6 and 12 months respectively) and in all domains (self-esteem, physical activity, social relationships, work performance, and sexual activity). Interestingly, global sexual activity improved at 6 months but not at 12 months. Some domains of sexual life improved at 6 months (desire, arousal, lubrication, satisfaction), but only the desire stayed improved at 12 months. CONCLUSION: Abdominoplasty and lower body lift improve the quality of life of patients after massive weight loss as well as the sexual quality of life. This should be an additional valid reason for promoting reconstructive surgery for massive weight loss patients.

Published
2023
Full Text
View/download PDF

2. Medial Thighplasty Improves Patient's Quality of Life After Massive Weight Loss: a Prospective Multicentric Study

Author

Silvia Gandolfi, Nicolas Bertheuil, Isabelle Pluvy, Eric Watier, Benoit Chaput, Maarten M. Hoogbergen, Camille Mocquard, CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Orthopedic, Traumatology, Plastic Reconstructive and Hand Surgery Unit (CHU Besançon), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Casselardit - Junod, CHU Rouen, Normandie Université (NU), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Adult, Plastic surgery, Reconstructive surgery, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Health change, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Weight loss, Weight Loss, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Prospective cohort study, Medial thighplasty, Retrospective Studies, 2. Zero hunger, Nutrition and Dietetics, business.industry, Middle Aged, Obesity, Morbid, 3. Good health, Female sexual function, Quality of Life, Physical therapy, Massive weight loss, Female, Surgery, medicine.symptom, business, Body mass index, 030217 neurology & neurosurgery, Post bariatric
Abstract

International audience; Background The aim of this study was to assess the impact of medial thighplasty following massive weight loss on the quality of life of patients and on their sexual life. Methods We performed a multicentric, prospective study on the quality of life after massive weight loss using the Short-Form 36 questionnaire, the Female Sexual Function Index questionnaire, and the Moorehead-Ardelt Quality of life questionnaire. Forty-nine patients who underwent medial thighplasty were included in three centers and evaluation was made pre- and post-operatively. Results The mean age of the patients was 44 +/- 12.5 years. The average pre-medial thighplasty body mass index was 27 +/- 3.8 kg/m(2). All the categories of the SF36 questionnaire scored higher after surgery apart from "health change" but only the "role limitations due to emotional problems" category was significantly improved (p= 0.0081). Similarly, the MooreheadArdelt questionnaire showed a positive impact of the surgery on the quality of life in general (mean total score 1.04 +/- 1.37) and on self- esteem, physical activity, social relationships, and work performance. Interestingly, sexual activity was not improved by the surgery and this result is in line with the FSFI, which showed no effect of medial thighplasty on sexual life. Conclusions Medial thighplasty improves the quality of life of patients after massive weight loss but does not seem to modify the sexual quality of life. These results clearly indicate that this surgery should be widely offered to patients seeking reconstruction of massive weight sequelae.

Published
2021
Full Text
View/download PDF

3. Risk Factors for Complications after J Medial Thighplasty following Massive Weight Loss: A Multivariate Analysis of 94 Consecutive Patients

Author

Farid Bekara, Silvia Gandolfi, Damien Bergeat, Jérôme Duisit, Nicolas Bertheuil, Eric Watier, CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Cliniques Universitaires Saint-Luc [Bruxelles], Université Catholique de Louvain = Catholic University of Louvain (UCL), Service de médecine nucléaire [Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Médecine Interne [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), UNIROUEN - UFR Santé (UNIROUEN UFR Santé), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU), Nutrition, Métabolismes et Cancer (NuMeCan), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service de chirurgie plastique, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)

Subjects
Adult, medicine.medical_specialty, Multivariate analysis, [SDV]Life Sciences [q-bio], Preoperative risk, Bariatric Surgery, 030230 surgery, Medial compartment of thigh, Severity of Illness Index, Body Mass Index, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Quality of life, Weight loss, Risk Factors, Weight Loss, medicine, Humans, Prospective Studies, 2. Zero hunger, business.industry, Medical record, Age Factors, Middle Aged, Body Contouring, Single surgeon, 3. Good health, Surgery, Obesity, Morbid, Thigh, Multivariate Analysis, Female, medicine.symptom, business, Body mass index
Abstract

International audience; BACKGROUND: Bariatric surgery has increased the number of patients requiring medial thighplasty after massive weight loss. However, despite the various complications, the procedure improves quality of life. The authors report postoperative complications of vertical J-shaped medial thigh lift in a series of patients and identify preoperative risk factors. METHODS: For almost 5 years, the details of all J medial thighplasties performed by a single surgeon were recorded; detailed medical records were also available. Complications can be major (e.g., need for early surgical revision or readmission) or minor (delayed wound healing). RESULTS: During the study period, 94 patients were treated and only minor complications were recorded (42.5 percent). On multivariate analysis, older age (OR, 1.05; 95 percent CI, 1.01 to 1.10) and a body mass index greater than or equal to 30 kg/m2 (OR, 2.82; 95 percent CI, 1.10 to 7.22) were independent risk factors for postoperative complications. CONCLUSIONS: As with other postbariatric operations, medial thighplasty is associated with significant morbidity, but the risk thereof can be easily established and managed. Specific algorithms for determining the risk of postoperative complications based on age and body mass index are needed to guide preoperative discussions with patients and perform patient selection. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.

Published
2021
Full Text
View/download PDF

4. Fleur-de-lys abdominal body contouring surgery following massive weight loss

Author

François Saget, Silvia Gandolfi, Yanis Berkane, Nicolas Bertheuil, Eric Watier, Théodoros Chrelias, CHU Pontchaillou [Rennes], CHU Rouen, Normandie Université (NU), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent

Subjects
medicine.medical_specialty, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, business.industry, Abdominoplasty, MEDLINE, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Body Contouring, 3. Good health, Body contouring surgery, Surgery, 03 medical and health sciences, 0302 clinical medicine, Weight loss, 030220 oncology & carcinogenesis, Abdomen, Weight Loss, medicine, Humans, medicine.symptom, business, Abdominal Muscles
Abstract

International audience; Refers to: DeSerres, J. J., Quaife, T., Morzycki, A., Curran, M. W., & Toy, J. (2021). Safety of fleur-de-lys abdominoplasty after massive weight loss. Journal of Plastic, Reconstructive & Aesthetic Surgery, 74(1), 223-243.

Published
2021
Full Text
View/download PDF

5. Use of a skin perforator flap pedicled by the intercostal muscle for reconstruction of a posterior cervical defect

Author

Nicolas Bertheuil, B. Menardais, F.M. Leclère, Jérôme Duisit, P. J. Le Reste, Eric Watier, CHU Pontchaillou [Rennes], Université Catholique de Louvain = Catholic University of Louvain (UCL), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Etablissement français du sang [Rennes] (EFS Bretagne), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Jonchère, Laurent, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, and UCL - (SLuc) Service de chirurgie plastique

Subjects
medicine.medical_specialty, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, Reconstruction tête et cou, Intercostal Muscles, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Metastatic Squamous Cell Lung Carcinoma, 03 medical and health sciences, Head and neck, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Perte de substance cervicale postérieure, Humans, Medicine, In patient, Cervical defect, Lambeau perforant, Adjuvant radiotherapy, business.industry, Osteomyelitis, Occipital bone, Occiput, Skin Transplantation, Plastic Surgery Procedures, medicine.disease, Perforator flap, Intercostal muscle flap, Spine, 3. Good health, Surgery, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Lambeau de muscles intercostaux, business, Neck, Intercostal muscle
Abstract

A posterior cervical defect featuring exposed spinal and occipital bone can be covered in various ways. The “ideal” flap should be a low-morbidity, pedicled locoregional flap that can reach the occiput. Cervical adjuvant radiation therapy may limit the coverage options, because many pedicles are located in areas that are often irradiated. Here, we describe a new surgical technique; we used a skin perforator flap pedicled by the intercostal muscle to cover a posterior cervical defect in a patient with metastatic squamous cell lung carcinoma. This technique is a valuable option; the flap originated from outside the irradiated area and reached the occiput. It adds to the options for cervical coverage in patients who require head-and-neck reconstruction.Evidence-Based MedicineLevel V: opinions of respected authorities, based on clinical experience, descriptive studies, or reports of expert committees., Les pertes de substances cervicales postérieures avec exposition osseuse peuvent être couvertes par plusieurs techniques. Le lambeau idéal doit avoir une faible morbidité, réalisable facilement, être un lambeau pédiculé locorégional et pouvoir atteindre l’occiput. En cas de radiothérapie cervicale, certains lambeaux classiques permettant de couvrir ce type de perte de substance peuvent avoir leur pédicule endommagé. Dans cet article, nous rapportons l’utilisation d’un lambeau perforant thoracique latéral pédiculé par les muscles intercostaux pour couvrir un defect cervical postérieur dans les suites d’une ostéosynthèse d’une métastase d’un carcinome pulmonaire. Ce lambeau est une alternative aux lambeaux traditionnels dont le pédicule est en dehors du champ d’irradiation. Il offre une option supplémentaire pour traiter ces defects.

Published
2021
Full Text
View/download PDF

6. Upper body lift and breast reshaping with lateral chest wall perforator propeller flap following massive weight loss

Author

Eric Watier, Benoit Chaput, N Isola, Nicolas Bertheuil, S. Aillet, Christian Herlin, CHU Pontchaillou [Rennes], Hôpital Lapeyronie [Montpellier] (CHU), STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), CCSD, Accord Elsevier, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
Reconstruction mammaire, medicine.medical_treatment, Mammaplasty, Breast reshaping, Chirurgie post-bariatrique, 030230 surgery, Mastopexy, Body Mass Index, 0302 clinical medicine, Postoperative Complications, Weight loss, Lambeau perforant, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, Lateral chest wall, Contouring, Hematoma, Propeller, Middle Aged, Body Contouring, Mastopexie, Augmentation mammaire autologue, medicine.anatomical_structure, Patient Satisfaction, Tissue and Organ Harvesting, Massive weight loss, Female, medicine.symptom, Adult, Reoperation, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, Upper trunk, [SDV.CAN] Life Sciences [q-bio]/Cancer, Weight Loss, medicine, Humans, Thoracic Wall, Bodylift supérieur, Bariatric surgery, business.industry, Perte de poids massive, Autologous breast augmention, Perforator flap, Surgery, Upper body lift, business, Body mass index, Perforator flaps, Follow-Up Studies
Abstract

Summary Background After massive weight loss (MWL), female patients often develop upper trunk laxity and severe breast deformities. Usually several procedures are required to address upper body contouring issues. Objectives To achieve better breasts and improve upper body contour, the authors employed a combined approach, associating lateral chest wall perforator propeller flaps with an upper bodylift (UBL). Methods Between September 2015 and March 2017, nine post-bariatric patients underwent simultaneously an UBL and autologous augmentation breast reshaping with lateral chest wall perforator propeller flaps. The authors analyzed the clinical indications, results and complications of this procedure. Results Eighteen lateral perforator propeller flaps for autologous breast augmentation-mastopexy associated with an UBL were performed successfully. Mean pre-MWL body mass index (BMI) was 54.3 ± 10.9 kg/m2, with a mean preoperative pre-UBL BMI of 28.7 ± 3.6 kg/m2. The average weight loss before surgery was 67.7 ± 22.4 kg. The flaps were harvested on intercostal and/or lateral thoracic arteries. All donor sites had been closed primarily. Following the classification of Dindo and Clavien, four minor complications (I, II), and two major complications (IIIb), including two hematomas requiring reoperation, were reported. No flap necrosis occurred. Follow-up averaged 27.9 ± 8.4 months. The patients’ satisfaction with their improved breast shapes and chest wall contours was “good”, with an aesthetic outcome mean ranked 3.8 ± 0.8 (out of 5). Conclusions After MWL, upper body deformities can be treated safely and reliably by a combined approach, associating an UBL and autologous lateral chest wall perforator flaps to provide more natural and durable breast shapes, as well as an upper circumferential reshaping.

Published
2020
Full Text
View/download PDF

7. Adipose mesenchymal stromal cells Definition, immunomodulatory properties, mechanical isolation and interest for plastic surgery

Author

Benoit Chaput, Eric Watier, Cédric Ménard, Audrey Varin, Karin Tarte, Jérôme Laloze, Nicolas Bertheuil, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), and CCSD, Accord Elsevier

Subjects
medicine.medical_specialty, Adipose stromal cells, Nanofat grafting, Adipose tissue, Tissu adipeux, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030230 surgery, Mesenchymal Stem Cell Transplantation, Regenerative Medicine, Regenerative medicine, Immunomodulation, 03 medical and health sciences, Paracrine signalling, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Fat grafting, Humans, Medicine, business.industry, Mesenchymal stem cell, Mesenchymal Stem Cells, Immunomodulatory properties, Stromal vascular fraction, Clinical routine, Adipose stem cells, 3. Good health, Plastic surgery, Adipose Tissue, Cellules souches, Cancer research, Surgery, business, Cellules stromales mésenchymateuses du tissu adipeux
Abstract

International audience; Ever since their discovery in 2001, adipose mesenchymal stromal cells (ASC) have profoundly modified clinical indications and our practice of plastic surgery, thereby placing our discipline at the forefront of regenerative medicine. These cells act through paracrine signaling by synthesizing immunosuppressive and pro-angiogenic factors. They are of key importance with regard to the regenerative properties of autologously grafted adipose tissue (AT). Taken together, they make up the stromal vascular fraction (SVF) comprising all AT cells except for adipocytes. As our knowledge evolves, we are moving from fat grafting towards SVF grafting, of which the essential sought-after effect is tissue regeneration. The objective of the present review is to synthesize present-day information on ASCs and their immunomodulatory properties and, from a practical standpoint, to indicate present-day and future steps towards establishment of clinical routine, particularly through application of techniques favoring mechanical digestion of adipose tissue.

Published
2019
Full Text
View/download PDF

8. The Lipo-Body Lift Operative Technique

Author

Camille Mocquard, Damien Bergeat, Benoit Chaput, Nicolas Bertheuil, Christophe Morvan, Eric Watier, Jonchère, Laurent, CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de Rangueil, CHU Toulouse [Toulouse], Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
Contouring, medicine.medical_specialty, Lift (data mining), business.industry, Gold standard, lcsh:Surgery, Video, [SDV.CAN]Life Sciences [q-bio]/Cancer, lcsh:RD1-811, 030230 surgery, Surgery, 03 medical and health sciences, 0302 clinical medicine, Lower body, [SDV.CAN] Life Sciences [q-bio]/Cancer, Weight loss, 030220 oncology & carcinogenesis, medicine, Postoperative results, medicine.symptom, business, Lower trunk
Abstract

International audience; Bariatric surgery induces massive weight loss, which results in global and complex skin deformities. Lower body lift procedure has become the gold standard for lower trunk reconstruction. The authors describe in this video the lipo-body lift technique in detail. The video is divided into 4 parts part 1, indications and preoperative markings; part 2, posterior contouring; part 3, anterior contouring; and part 4, preoperative and postoperative results. Patient selection and technical key points of the technique are discussed. The lipo-body lift method is an important component of reconstructive strategies and should be widely offered to patients who experienced massive weight loss.

Published
2019
Full Text
View/download PDF

9. Lower Body Lift in the Massive Weight Loss Patient A New Classification and Algorithm for Gluteal Augmentation

Author

Benoit Chaput, Nathalie Kerfant, Eric Watier, Benoist Menardais, Isabelle Pluvy, Nicolas Bertheuil, CHU Pontchaillou [Rennes], Hôpital de la Cavale Blanche - CHRU Brest (CHU - BREST ), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Lift (data mining), business.industry, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030230 surgery, Surgical Flaps, Surgery, 03 medical and health sciences, 0302 clinical medicine, Lower body, medicine.anatomical_structure, Weight loss, 030220 oncology & carcinogenesis, Weight Loss, Buttocks, Humans, Medicine, medicine.symptom, business, Algorithms, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
Full Text
View/download PDF

10. Safe monsplasty technique

Author

Antoine De Runz, Audrey Patoué, S. Aillet, Raphael Carloni, Nicolas Bertheuil, Eric Watier, CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Maladies chroniques, santé perçue, et processus d'adaptation (APEMAC), Université de Lorraine (UL), CHU Rouen, Normandie Université (NU), Microenvironnement et cancer (MiCa), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
Adult, medicine.medical_specialty, Esthetics, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Bariatric Surgery, 030230 surgery, Patient Positioning, bodylift, Cohort Studies, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Weight loss, plastic surgery, Weight Loss, pubic lift, Medicine, Humans, Surgery, Plastic, Mons pubis, Pubic Bone, Retrospective Studies, mons pubis, Abdominoplasty, business.industry, Monsplasty, Middle Aged, Body Contouring, 3. Good health, Surgery, Obesity, Morbid, Plastic surgery, medicine.anatomical_structure, Patient Satisfaction, Quality of Life, Female, abdominoplasty, Patient Safety, medicine.symptom, business
Abstract

International audience; Introduction - To improve their health and quality of life, obese patients undergo consultation after weight loss. In these patients, the sub-umbilical abdominal and pubic regions are often characterized by redundant skin, creating aesthetic and functional discomfort. Monsplasty is an important step in abdominoplasty or bodylift procedures. We report on an original technique used to correct deformity in the pubic region following weight loss. Methods - All interventions were performed by the same surgeon between April and December 2015. On stretched skin, we drew two lines 5 cm lateral to the median line on both sides and connected them with the arc of a circle placed 7 cm from the vulvar fork. Then, monsplasty marks extend to abdominal fold. During lower abdominal contouring, we performed monsplasty with three separate stitches between the camper fascia and aponeurosis of the abdominal muscle. The aim was to bring tension to the pubic region without additional surgical procedure. Results - We report on 21 consecutive cases of monsplasty following lower trunk contouring. No reoperation was performed due to complication or aesthetic demand (no under- or over-correction occurred). No complication (e.g. edema, seroma, disturbance of sensibility) was observed in the pubic area. The results were stable 1 year after surgery. Conclusions - We report on a simple, rapid, and reproducible monsplasty technique for all stages of Pittsburgh classifications, which achieved favorable results with no complication. We recommend performance of this effective technique simultaneously with abdominoplasty or bodylift procedures. Level of evidence - IV.

Published
2018
Full Text
View/download PDF

11. Outpatient Circumferential Lower Body Lift: Is the Lipo-Body Lift an Ideal Method?

Author

Nicolas Bertheuil, Eric Watier, Isabelle Pluvy, Marie Panouilleres, Benoit Chaput, D. Feuvrier, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Rangueil, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], Etablissement français du sang [Rennes] (EFS Bretagne), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Lower body, Lift (data mining), business.industry, Mechanical engineering, Medicine, Surgery, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030230 surgery, business, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
Full Text
View/download PDF

12. Postero-Inferior Pedicle Surgical Technique for the Treatment of Grade III Gynecomastia

Author

Sophie Thienot, Cécile Meal, Nicolas Bertheuil, R. Carloni, S. Aillet, Christian Herlin, Eric Watier, Etablissement français du sang [Rennes] (EFS Bretagne), Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Plastic and Craniofacial Pediatric Surgery, Hôpital Lapeyronie [Montpellier] (CHU), chirurgie plastique, reconstructrice et esthétique, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, medicine.medical_treatment, Mammaplasty, 030230 surgery, Severity of Illness Index, Surgical Flaps, Body Mass Index, Cohort Studies, 030207 dermatology & venereal diseases, 0302 clinical medicine, skin and connective tissue diseases, Areola, health care economics and organizations, Graft Survival, Middle Aged, Plastic surgery, medicine.anatomical_structure, Treatment Outcome, Gynecomastia, Patient Satisfaction, 030220 oncology & carcinogenesis, Nipples, [SDV.IMM]Life Sciences [q-bio]/Immunology, France, Mastectomy, Adult, musculoskeletal diseases, medicine.medical_specialty, Esthetics, education, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Risk Assessment, 03 medical and health sciences, Young Adult, Lipectomy, medicine, Humans, Retrospective Studies, Wound Healing, business.industry, Plastic Surgery Procedures, medicine.disease, Neurovascular bundle, Surgery, Transplantation, stomatognathic diseases, Otorhinolaryngology, Liposuction, business
Abstract

Surgical treatment of Grade III gynecomastia generally utilizes mastectomy techniques and free transplantation of the nipple–areola complex. Moreover, with rising obesity rates and the development of bariatric surgery, an increasing demand for correctional surgery for pseudogynecomastia has been observed, which is comparable to Grade III gynecomastia in terms of its surgical management. Here, we describe an innovative technique to deal with these new demands: fascio-cutaneous flap by postero-inferior pedicle. All patients in the Department of Plastic Surgery from our University Hospital suffering from Grade III gynecomastia or pseudogynecomastia underwent surgery via the postero-inferior pedicle flap technique. Briefly, we performed extensive liposuction of the infero-internal and infero-external mammary quadrants followed by liposuction of the deep tissues of the superior quadrants, except in the area of the pedicle. After removing the skin just above the dermis of the inferior quadrants and performing de-epithelialization of the postero-inferior pedicle flap, the thoracic flap was lowered and the areola transposed. Nine patients underwent surgery between March 2015 and March 2016, and their results were collected prospectively. The mean patient age was 46.6 years, the mean weight was 94.2 kg, and the mean body mass index was 30.8 kg/m2. In addition, the mean operative time was 132 min, the mean liposuction volume was 633 mL, the excised weight was 586 g, and the mean hospitalization and drainage durations were 3.8 days. No major complications occurred, no re-intervention was required, and no recurrence was found. We report a new operative technique using a postero-inferior pedicle. Its main advantage is preservation of neurovascular function, which makes this a promising technique for patients who wish to maintain nipple sensitivity. This surgery is reliable and reproducible. We recommend it as the first line treatment for Grade III gynecomastia because of its low rate of major complications and favorable functional and esthetic results. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Published
2017
Full Text
View/download PDF

13. Modified Lipoabdominoplasty: Updating Concepts-Our Postbariatric Experience

Author

Raphael Carloni, Christian Herlin, Nicolas Bertheuil, Eric Watier, Audrey Patoué, Benoit Chaput, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], Department of Plastic and Craniofacial Pediatric Surgery, Hôpital Lapeyronie [Montpellier] (CHU), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Etablissement français du sang [Rennes] (EFS Bretagne), Centre Hospitalier Universitaire de Rangueil, Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Information retrieval, business.industry, Abdominoplasty, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030230 surgery, 03 medical and health sciences, 0302 clinical medicine, Lipectomy, 030220 oncology & carcinogenesis, Humans, Medicine, Surgery, business, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; no abstract

Published
2017
Full Text
View/download PDF

14. Contribution of Lower Body Lift in the Correction of Medial Thigh Deformity following Massive Weight Loss

Author

Eric Watier, Paul Girard, Benoit Chaput, Nicolas Bertheuil, Antoine De Runz, Raphael Carloni, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Lift (data mining), business.industry, Dermatologic Surgical Procedures, [SDV.CAN]Life Sciences [q-bio]/Cancer, Anatomy, Plastic Surgery Procedures, 030230 surgery, Medial compartment of thigh, 03 medical and health sciences, 0302 clinical medicine, Lower body, Lipectomy, Thigh, Weight loss, 030220 oncology & carcinogenesis, Weight Loss, medicine, Deformity, Humans, Surgery, medicine.symptom, business, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; [No abstract available]

Published
2017
Full Text
View/download PDF

15. The Lipo-Body Lift: A New Circumferential Body-Contouring Technique Useful after Bariatric Surgery

Author

Eric Watier, Antoine De Runz, Nicolas Bertheuil, Benoit Chaput, Paul Girard, Raphael Carloni, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Etablissement français du sang [Rennes] (EFS Bretagne), Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
2. Zero hunger, medicine.medical_specialty, business.industry, Wound dehiscence, medicine.medical_treatment, [SDV.CAN]Life Sciences [q-bio]/Cancer, Perioperative, 030230 surgery, medicine.disease, 3. Good health, Surgery, 03 medical and health sciences, 0302 clinical medicine, Hematoma, Weight loss, 030220 oncology & carcinogenesis, Liposuction, Body contouring, medicine, Fat necrosis, medicine.symptom, business, Body mass index
Abstract

International audience; Background: After bariatric surgery, lifting of the lower body involves a contouring technique used to achieve optimal lower trunk reconstruction. The authors describe an innovative procedure applicable after massive weight loss: the lipo-body lift method. The authors describe their experience with this novel, safe procedure. Methods: Twenty-five abdominal body-contouring reconstructions following massive weight loss were treated by means of circumferential lipo-body lift. The authors describe the indications for the procedure and their perioperative and postoperative management. Results: The mean patient age was 39.4 years. The mean pre-body lift body mass index was 26.71 kg/m2; the average weight loss before surgery was 56.6 kg, with a mean delta body mass index loss of 20.82 kg/m2. The average hospital stay was 3.52 days and the drainage duration 3.56 days. No patient experienced any major complication (e.g., hematoma, thromboembolism, bleeding, skin necrosis, or a need for revision surgery to treat complications). Minor complications including wound dehiscence, wound infection, and fat necrosis were reported in 40 percent of patients. The occurrence of complications was associated with smoking status (p = 0.0280), the volume of liposuction (p = 0.0399), and the liposuction volume per unit of body mass index (p = 0.0071). Conclusions: The authors' novel technique is less invasive than the traditional lower body-lifting method, as shown by the absence of major complications, and allows excellent conservation of connective tissue and vessels; undermining is minimal. As obesity becomes a major problem worldwide, lifting procedures that are safe and effective are important components of reconstructive strategies and should be widely offered to patients who experience massive weight loss. Copyright © 2016 American Society of Plastic Surgeons.

Published
2017
Full Text
View/download PDF

16. Scalp Tissue Expansion Above a Custom-Made Hydroxyapatite Cranial Implant to Correct Sequelar Alopecia on a Transposition Flap

Author

Eric Watier, Nicolas Bertheuil, R. Carloni, Benoit Chaput, Christian Herlin, Antoine De Runz, Hôpital Charles Nicolle [Rouen], CHU Pontchaillou [Rennes], Hôpital Lapeyronie [Montpellier] (CHU), STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Pratiques professionnelles : aspects méthodologiques, éthiques et juridiques (ETHOS), Université de Lorraine (UL), Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], Microenvironnement et cancer (MiCa), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Etablissement français du sang [Rennes] (EFS Bretagne), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )

Subjects
Male, Skin Neoplasms, medicine.medical_treatment, Surgical Flaps, MESH: Transposition flap, 0302 clinical medicine, Medicine, Soft tissue, Prostheses and Implants, Skin Transplantation, Cranioplasty, Calvarial reconstruction, 3. Good health, medicine.anatomical_structure, Head and Neck Neoplasms, 030220 oncology & carcinogenesis, MESH: Tissue, Transposition flap, MESH: Alopecia, Craniotomy, Adult, medicine.medical_specialty, Skull Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, MESH: Calvarial reconstruction, Resection, Prosthesis Implantation, 03 medical and health sciences, MESH: expansion, Humans, Neoplasm Invasiveness, Scalp, business.industry, Dermatofibrosarcoma, Skull, Alopecia, Plastic Surgery Procedures, Vertex (anatomy), Surgery, Durapatite, Tissue expansion, MESH: Cranioplasty, Neurology (clinical), Implant, business, 030217 neurology & neurosurgery, Cranial implant
Abstract

International audience; Background:Resection of cranial tumors involving both bone and scalp tissue may require the recruitment of soft tissue using a flap above the bone reconstruction. When a transposition flap has been chosen, the alopecia zone on the donor site may be difficult to treat afterward. Scalp expansion is the gold standard in these situations, but this has never been described above cranial implants. We report the first case of a patient who underwent a scalp tissue expansion above a custom-made hydroxyapatite cranial implant to correct sequelar alopecia.Case Description: A 30-year-old man presented with a dermatofibrosarcoma of the scalp with bone invasion. A cranioplasty with a custom-made hydroxyapatite implant and a transposition flap were performed. Although healing was achieved, the donor site of the transposition flap left a 9 × 13 cm sequelar alopecia area on the vertex. To correct it, a rectangular 340-cm3 expander was partially placed above the cranial implant and under the transposition flap. A second 120-cm3 expander was put on the contralateral temporal region. The expansion was successful. No expander infection, cranial implant displacement, or fracture on imaging performed during the follow-up period was detected. The alopecia zone was entirely excised. The patient was very satisfied with the cosmetic result.Conclusions: Tissue expansion above hydroxyapatite implants may be of concern to the physician because of the risk of infection and rupture of the cranial implant. With this clinical case, we emphasize some precautions to prevent these issues.

Published
2016
Full Text
View/download PDF

17. Eyelid fat grafting: indications, operative technique and complications; a systematic review

Author

Benoit Chaput, Antoine De Runz, Bruno Mortemousque, Raphael Carloni, Christian Herlin, Frédéric Mouriaux, Sahar Bannani, Eric Watier, Nicolas Bertheuil, Elodie Boureaux, Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Centre Hospitalier Universitaire de Rangueil, Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CHU Pontchaillou [Rennes], Université de Rennes 1 - Faculté de Médecine (UR1 Médecine), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Microenvironnement et cancer (MiCa), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Etablissement français du sang [Rennes] (EFS Bretagne), STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Université de Rennes - Faculté de Médecine (UR Médecine), Université de Rennes (UR), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, fat transplantation, Facial rejuvenation, Grafting (decision trees), [SDV]Life Sciences [q-bio], Physical examination, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Transplantation, Autologous, 03 medical and health sciences, 0302 clinical medicine, Patient satisfaction, facial rejuvenation, medicine, Humans, Prospective Studies, Retrospective Studies, adipose-derived stem cell, Protocol (science), medicine.diagnostic_test, business.industry, cosmetic surgery, Eyelids, Plastic Surgery Procedures, lipofilling, 3. Good health, Surgery, Eyelid, medicine.anatomical_structure, Systematic review, Adipose Tissue, Otorhinolaryngology, Patient Satisfaction, Tissue and Organ Harvesting, 030221 ophthalmology & optometry, Oral Surgery, Complication, business, fat grafting
Abstract

International audience; Introduction - Many recent studies concerning autologous fat grafting in the eyelids have been published, mostly consisting of case reports and retrospective case series. However, no study on the overall complication or satisfaction rate associated with the various grafting techniques exists. We performed a comprehensive literature review to determine the outcomes and complications of eyelid fat grafting, as well as patient satisfaction.Methods - A systematic review of the literature using the PRISMA criteria was conducted. This protocol was registered at the Prospective Register of Systematic Reviews at the National Institute for Health Research.Results - Sixteen studies, representing 1,159 patients and published between June 2004 and December 2014, were included. Satisfactory results, judged by clinical examination, were observed in all studies. Few postoperative complications were reported.Conclusions - We demonstrated that the procedures were easy to perform, and achieved satisfactory and sustainable results with few complications in both reconstructive and cosmetic surgery. However, a wide disparity exists in the various fat harvesting, fat purification, and reinjection techniques. Further studies are required to assess the long-term outcomes. Our conclusions should be accepted cautiously due to the small number of articles and the lack of evidence in published studies.

Published
2016
Full Text
View/download PDF

18. Lower Body Lift after Massive Weight Loss: Autoaugmentation versus No Augmentation

Author

Nicolas Bertheuil, Eric Watier, Raphael Carloni, Christian Herlin, Benoit Chaput, Etablissement français du sang [Rennes] (EFS Bretagne), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Microenvironnement et cancer (MiCa), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Department of Plastic and Craniofacial Pediatric Surgery, Hôpital Lapeyronie [Montpellier] (CHU), Centre Hospitalier Universitaire de Rangueil, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], 030230 surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Lower body, Patient satisfaction, Weight loss, Weight Loss, medicine, Humans, Buttocks, ComputingMilieux_MISCELLANEOUS, Lift (data mining), business.industry, Plastic Surgery Procedures, medicine.anatomical_structure, Patient Satisfaction, 030220 oncology & carcinogenesis, Physical therapy, Female, Surgery, medicine.symptom, business
Abstract

International audience; no abstract

Published
2016
Full Text
View/download PDF

19. Abdominoplasty: risk factors, complication rates, and safety of combined procedures

Author

Raphael Carloni, Christian Herlin, Benoit Chaput, Eric Watier, Nicolas Bertheuil, Etablissement français du sang [Rennes] (EFS Bretagne), Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], STROMALab, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Microenvironnement et cancer (MiCa), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), Université Montpellier 1 (UM1)-Université de Montpellier (UM), Centre Hospitalier Universitaire de Rangueil, Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)

Subjects
medicine.medical_specialty, Abdominoplasty, business.industry, medicine.medical_treatment, [SDV]Life Sciences [q-bio], MEDLINE, Retrospective cohort study, 030230 surgery, 3. Good health, Surgery, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Lipectomy, Risk Factors, 030220 oncology & carcinogenesis, medicine, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Complication, business, ComputingMilieux_MISCELLANEOUS, Retrospective Studies
Abstract

International audience; Letter to the Editor

Published
2016
Full Text
View/download PDF

20. Les cellules stromales mésenchymateuses du tissu adipeux : historique, isolement, propriétés immunomodulatrices et perspectives cliniques [Adipose-derived stromal cells: History, isolation, immunomodulatory properties and clinical perspectives]

Author

Benoit Chaput, Ignacio Garrido, J L Grolleau, Karin Tarte, Nicolas Bertheuil, Eric Watier, Luc Sensebé, Audrey Varin, Cédric Ménard, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Microenvironnement et cancer (MiCa), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), and Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS)

Subjects
Stromal cell, Stromal vascular fraction, [SDV]Life Sciences [q-bio], Mesenchymal stromal cells, Regenerative medicine, Fraction vasculaire stromale, Cell therapy, 03 medical and health sciences, Paracrine signalling, 0302 clinical medicine, In vivo, medicine, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Cellules stromales mésenchymateuses, Propriétés anti-inflammatoires, 0303 health sciences, business.industry, Mesenchymal stem cell, Anti-inflammatory effect, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, Surgery, Bone marrow, Stem cell, business, Médecine régénérative, Immunosuppression
Abstract

Over the last decade, the clinical use of adipose-derived stromal/stem cells (ASC) in regenerative medicine is rapidly increasing. ASC belong to the mesenchymal stromal cells initially obtained from the bone marrow. Their limited differentiation capacity in vivo into functional mature cells has led to a reassessment of their mechanisms of action. One of the major clinical interests appears related to paracrine effects through a temporary production of trophic and immunomodulatory factors. Our purpose is to provide a review on the latest knowledge in the field of ASC, mechanisms of action, mainly immunomodulatory/immunosuppressive properties, methods of obtention, with a focus on clinical perspectives particularly in the field of cellular therapy and fat grafting technique in plastic surgery.

Published
2015
Full Text
View/download PDF

21. Inguinal Lymphadenectomy For Stage Iii Melanoma: A Comparative Study Of Two Surgical Approaches At The Onset Of Lymphoedema

Author

N. Bertheuil, Bernard Meunier, Laurent Sulpice, Eric Watier, G.B. Levi Sandri, Vincent Lavoué, STROMALab, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], EFS, Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes], Service de Gynécologie et Obstétrique [Rennes] = Gynaecology [Rennes], Service de Chirurgie Plastique, Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Etablissement Français du Sang-Institut National de la Santé et de la Recherche Médicale (INSERM), Lecoupe-Grainville, Marie, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement Français du Sang-Centre National de la Recherche Scientifique (CNRS), Service de chirurgie plastique, reconstructive et esthétique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CHU Pontchaillou [Rennes]-Hôpital Sud, Service de Chirurgie Hépatobiliaire et Digestive, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Pôle de gynécologie, obstétrique et médecine de la reproduction[Rennes], and CHU Pontchaillou [Rennes]-Hôpital Anne-de-Bretagne

Subjects
Adult, Male, medicine.medical_specialty, Skin Neoplasms, [SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery, medicine.medical_treatment, Sentinel lymph node, Inguinal Canal, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Surgical Wound Dehiscence, Inguinal lymphadenectomy, Necrosis, 03 medical and health sciences, 0302 clinical medicine, Stage III melanoma, Humans, Surgical Wound Infection, Medicine, Lymphedema, Melanoma, Aged, Neoplasm Staging, Skin, integumentary system, business.industry, Wound dehiscence, General Medicine, Middle Aged, medicine.disease, Inguinal canal, 3. Good health, Surgery, Dissection, Seroma, medicine.anatomical_structure, Lymphoedema, Oncology, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Chronic Disease, Lymph Node Excision, Female, Lymphadenectomy, business
Abstract

International audience; Introduction: When sentinel lymph node is positive for metastasis (exclusion for micro-metastasis) and in cases of palpable adenopathy, a lymphadenectomy should be performed. Many incisional surgical approach have been described in literature. We perform two type of incision (vertical with skin excision and transversal) for inguinal lymphadenectomy. The aim of this study was to compare post-operative morbidity between these two approach in cases of Stage III Melanoma. We analyzed chronic lymphoedeme, skin necrosis, wound dehiscence, wound infection and seroma rates between the two techniques.-three patients underwent to inguinal lymphadenectomy for Stage III melanoma at CHU of Rennes. Patients were stratified in 2 groups according to the surgical approach, group 1 with a vertical incision with skin excision and group 2 with a transverse incision. Results: Chronic lymphedema rate for group 1 was 37.04% and for group 2 rate was 26.92%, this complication was lower un group 2 but no significant difference was observed (p=0.558). Skin necrosis (p=0.235), wound dehiscence (p=1.000), wound infection (p=0.236) and seroma (p=0.757) were not significantly different. Two cases of skin necrosis were observed in group 2 (7.69%) and none in group 1. Conclusion: We do not found significant difference for chronic lymphedema between these two approach. However, we had less lymphedema with the transversal technique which has the advantage to reduce the skin suffering when external iliac lymphadenectomy dissection is necessary in addition to the inguinal lymphadenectomy.

Published
2014
Full Text
View/download PDF

22. Biceps femoris flap for closure of ischial pressure ulcers

Author

Nicolas Bertheuil, S. Aillet, Vincent Huguier, Marion Beuzeboc, Eric Watier, Service de chirurgie plastique, reconstructive et esthétique [Rennes] = Cosmetic Reconstructive and Plastic surgery [Rennes], CHU Pontchaillou [Rennes], Service de chirurgie plastique et reconstructive, and Centre hospitalier universitaire de Poitiers (CHU Poitiers)

Subjects
Reconstructive surgery, medicine.medical_specialty, business.industry, [SDV]Life Sciences [q-bio], 030230 surgery, medicine.disease, Biceps, Pressure ulcer, 3. Good health, Surgery, Biceps femoris flap, Log-rank test, 03 medical and health sciences, Plastic surgery, 0302 clinical medicine, 030220 oncology & carcinogenesis, Seroma, medicine, Risk factor, Myocutaneous flap, business, Spinal cord injury
Abstract

Conflict of interest : None; International audience; Background : The surgical management of stages III and IV pressure ulcers in spinal cord injury patients is ussually based on a large debridment of necrotic tissue before performing a cover of the defect by a flap. The purpose of our study is to analyze our results in terms of morbidity and recurrence of pressure ulcers covered by biceps femoris musculocutaneous flap and compares it with literature data. Methods : A retrospective clinical study of 23 consecutive patients operated for stage IV ischial pressure ulcers by biceps femoris flap was carried out. Other surgical techniques coverage of pressure ulcers as well as all patients with pressure ulcers on another anatomical location were excluded from this study. An analytical statistics in search of a risk factor for recurrence by log rank test was also performed. Results : The mean follow-up was 68.4 months. Primary healing was obtained without complications in 30.8 and 38.4 % had a recurrence of the ulcer. Seroma was statistically correlated to a significant risk of recurrence of pressure ulcers (p = 0.0284, log rank test), as well as to drains removal before the eighth day (p = 0.0114). Conclusions : Surgical management of ischial pressure ulcers remains as a difficult procedure with significant postoperative complications and a high recurrence rate. Level of Evidence: Level IV, therapeutic study.

Published
2013
Full Text
View/download PDF

23. Merkel cell polyomavirus small T antigen mRNA level is increased following in vivo UV-radiation

Author

Ariane Mogha, Laurent Misery, Eric Watier, Alain Fautrel, Marie-Dominique Galibert, Henri Adamski, Na Guo, Sébastien Corre, Nicolas Mouchet, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Plate-forme d'histopathologie, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Proclaim, Service de Dermatologie [Rennes] = Dermatology [Rennes], CHU Pontchaillou [Rennes], Service de Chirurgie Plastique, Laboratoire de Neurobiologie Cutanée, Université de Brest (UBO), Service de Génétique Moléculaire et Génomique, Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université de Rennes (UR), Service de Génétique moléculaire et Génomique [CHU Rennes], and De Villemeur, Hervé

Subjects
Antigens, Polyomavirus Transforming, lcsh:Medicine, Merkel cell polyomavirus, Polymerase Chain Reaction, Merkel Cells, law.invention, Dermatology/Skin Cancers, including Melanoma and Lymphoma, 0302 clinical medicine, law, lcsh:Science, Polymerase chain reaction, 0303 health sciences, Multidisciplinary, MESH: Middle Aged, biology, integumentary system, Merkel cell carcinoma, food and beverages, Genetics and Genomics/Gene Expression, Middle Aged, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, RNA extraction, Merkel cell, Research Article, Adult, Ultraviolet Rays, [SDV.CAN]Life Sciences [q-bio]/Cancer, In Vitro Techniques, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Antigen, medicine, Carcinoma, Humans, RNA, Messenger, 030304 developmental biology, MESH: RNA, Messenger, MESH: Humans, MESH: Antigens, Polyomavirus Transforming, lcsh:R, MESH: Adult, MESH: Carcinoma, Merkel Cell, MESH: Polymerase Chain Reaction, medicine.disease, biology.organism_classification, Molecular biology, Carcinoma, Merkel Cell, MESH: Merkel Cells, lcsh:Q, MESH: Ultraviolet Rays, Skin cancer, MESH: Female, Virology/Viruses and Cancer
Abstract

International audience; Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer involving Merkel cells. Recently, a new human polyomavirus was implicated in MCC, being present in 80% of the samples analyzed. In virus-positive MCC, the Merkel cell polyomavirus (MCPyV) is clonally integrated into the patients DNA, and carries mutations in its large T antigen, leading to a truncated protein. In non-symptomatic tissue MCPyV can reside at very low levels. MCC is also associated with older age, immunosuppression and sun exposure. However, the link with solar exposure remains unknown, as the precise mechanism and steps involved between time of infection by MCPyV and the development of MCC. We thus investigated the potential impact of solar simulated radiation (SSR) on MCPyV transcriptional activity. We screened skin samples of 20 healthy patients enrolled in a photodermatological protocol based on in vivo-administered 2 and 4 J/cm(2) SSR. Two patients were infected with two new variants of MCPyV, present in their episomal form and RT-QPCR analyses on SSR-irradiated skin samples showed a specific and unique dose-dependent increase of MCPyV small t antigen transcript. A luciferase based in vitro assay confirmed that small t promoter is indeed UV-inducible. These findings demonstrate that solar radiation has an impact on MCPyV mRNA levels that may explain the association between MCC and solar exposure.

Published
2010
Full Text
View/download PDF

24. In vivo and ex vivo UV-induced analysis of pigmentation gene expressions

Author

Marie-Dominique Galibert, Karim Mekideche, Eric Watier, Jean Mosser, Sébastien Corre, Henri Adamski, Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Service de Dermatologie [Rennes] = Dermatology [Rennes], CHU Pontchaillou [Rennes], Plate-forme transcriptome, Université de Rennes (UR), Service de Chirurgie Plastique, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)

Subjects
0303 health sciences, [SDV.GEN]Life Sciences [q-bio]/Genetics, Chemistry, Ultraviolet Rays, Gene Expression, Skin Pigmentation, Cell Biology, Dermatology, Biochemistry, Cell biology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, In vivo, Gene expression, Humans, Molecular Biology, Gene, Ex vivo, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, Skin
Abstract

International audience; no abstract

Published
2006
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results