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2 results on '"FAMILY-MEMBERS"'

1. The concept of a surrogate is ill adapted to intensive care: Criteria for recognizing a reference person

Author

Jean-Philippe Rigaud, François Bougerol, Corinne Quesnel, Stéphanie Gelinotte, Nicolas Meunier-Beillard, Jean-Pierre Quenot, Pierre-Louis Declercq, Jean-Baptiste Hardy, Jean-Pierre Eraldi, Fiona Ecarnot, Hervé Devilliers, Centre hospitalier de Dieppe, Centre Georges Chevrier. Savoirs : Normes & Sensibilités (FRE3499) ( CGC ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques ( CIC-EC ), Université de Bourgogne ( UB ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de médecine interne et maladies systémiques (SOC 2) [CHU de Dijon], Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( PCVP / CARDIO ), Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ) -Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre Georges Chevrier. Sociétés & Sensibilités [Dijon - UMR7366] (CGC), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marqueurs pronostiques et facteurs de régulations des pathologies cardiaques et vasculaires - UFC ( EA 3920) (PCVP / CARDIO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Lipides - Nutrition - Cancer (U866) (LNC), and Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)

Subjects
Adult, Male, Unit patients, Designation, Critical Care, Medical information, Decision Making, Patient Advocacy, Critical Care and Intensive Care Medicine, Patient advocacy, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Nursing, law, Physicians, Surveys and Questionnaires, Intensive care, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, Health care, Humans, Medicine, Young adult, Family-members, Aged, Response rate (survey), Ethics, business.industry, Questionnaire, Surrogate, 030208 emergency & critical care medicine, Middle Aged, Intensive care unit, Proxy, 3. Good health, Caregivers, 030228 respiratory system, Scale (social sciences), Respondent, Symptoms, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

IF 2.445; International audience; Purpose: In the intensive care unit (ICU), caregivers may find it difficult to identify a suitable person in the patient's entourage to serve as a reference when there is no official surrogate.Methods: We developed a 12-item questionnaire to identify factors potentially important for caregivers when identifying a reference person. Each criterion was evaluated as regards its importance for the role of reference. Responses were on a scale of 0 (not important) to 10 (extremely important). We recorded respondent's age, job title, and number of years' ICU experience. The questionnaire was distributed to all health care professionals in 2 French ICUs.Results: Among 144 staff, 128 were contacted; 99 completed the questionnaire (77% response rate; 20 physicians [ 11 residents], 51 nurses, 28 nurse's aides). Items classed as most important attributes for a reference person were knowledge of patient's wishes and values, emotional attachment, adequate understanding of the clinical history, and designation as a surrogate before admission. There were no significant differences according to respondent's age, job title, or experience.Conclusion: Caregivers identify a reference person based on criteria such as knowledge of the patient's wishes, emotional bond with the patient, an adequate understanding of the clinical history, and designation as surrogate before admission. (C) 2015 Elsevier Inc. All rights reserved.

Published
2016
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2. Vfm a new quorum sensing system controls the virulence of Dickeya dadantii

Author

Nasser, William, Dorel, Corinne, Wawrzyniak, Julien, Van Gijsegem, Frédérique, Groleau, Marie-Christine, Déziel, Eric, Reverchon, Sylvie, Chromatine et Régulation de la Pathogénie bactérienne (CRP), Microbiologie, adaptation et pathogénie (MAP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Interactions Plantes Pathogènes (IPP), Institut National de la Recherche Agronomique (INRA)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National Agronomique Paris-Grignon (INA P-G), Institut Armand Frappier (INRS-IAF), Institut National de la Recherche Scientifique [Québec] (INRS)-Réseau International des Instituts Pasteur (RIIP), This work was supported by grants from the Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon, and Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS)

Subjects
H-NS, BLUE PIGMENT, EXPRESSION, MESH: Signal Transduction, MESH: Operon, GENES, MESH: Mutation, GLOBAL REGULATOR, MESH: Virulence, MESH: Quorum Sensing, MESH: Gene Order, MESH: Enterobacteriaceae, Bacterial Proteins, Enterobacteriaceae, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Gene Order, Operon, PECT REPRESSOR, GRAM-NEGATIVE BACTERIA, MESH: Bacterial Proteins, MESH: Gene Expression Regulation, Bacterial, Virulence, Quorum Sensing, Gene Expression Regulation, Bacterial, FAMILY-MEMBERS, BACTERIUM ERWINIA-CHRYSANTHEMI, ESCHERICHIA-COLI, Multigene Family, Mutation, MESH: Multigene Family, Signal Transduction
Abstract

International audience; Dickeya dadantii is a plant pathogen that secretes cell wall-degrading enzymes (CWDE) that are responsible for soft-rot symptoms. Virulence genes are expressed in a concerted manner and culminate when bacterial multiplication slows. We identify a 25 kb vfm cluster required for D. dadantii CWDE production and pathogenesis. The vfm cluster encodes proteins displaying similarities both with enzymes involved in amino acid activation and with enzymes involved in fatty acid biosynthesis. These similarities suggest that the vfm genes direct the production of a metabolite. Cell-free supernatant from the D. dadantii wild-type strain restores CWDE production in vfm mutants. Collectively, our results indicate that vfm genes direct the synthesis of an extracellular signal and constitute a new quorum sensing system. Perception of the signal is achieved by the two-component system VfmH-VfmI, which activates the expression of the vfmE gene encoding an AraC regulator. VfmE then activates both the transcription of the CWDE genes and the expression of the vfm operons. The vfm gene cluster does not seem to be widespread among bacterial species but is conserved in other Dickeya species and could have been laterally transferred to Rahnella. This work highlights that entirely new families of bacterial languages remain to be discovered.

Published
2013
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