1. An extension of Phase Linearity Measurement for revealing cross frequency coupling among brain areas
- Author
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Michele Ambrosanio, Rosaria Rucco, Pierpaolo Sorrentino, Fabio Baselice, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
Computer science ,Phase (waves) ,Normal Distribution ,Health Informatics ,030218 nuclear medicine & medical imaging ,lcsh:RC321-571 ,03 medical and health sciences ,symbols.namesake ,0302 clinical medicine ,Synchronization (computer science) ,Broadband ,Neural Pathways ,Connectivity metrics ,Humans ,Computer Simulation ,Brain connectivity ,Cortical Synchronization ,Gaussian process ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Cross frequency synchronization ,Cross frequency coupling ,Research ,[SCCO.NEUR]Cognitive science/Neuroscience ,Rehabilitation ,Linearity ,Brain ,Magnetoencephalography ,Extension (predicate logic) ,Healthy Volunteers ,Phase coupling ,symbols ,A priori and a posteriori ,Algorithm ,030217 neurology & neurosurgery ,Algorithms - Abstract
Background Brain areas need to coordinate their activity in order to enable complex behavioral responses. Synchronization is one of the mechanisms neural ensembles use to communicate. While synchronization between signals operating at similar frequencies is fairly straightforward, the estimation of synchronization occurring between different frequencies of oscillations has proven harder to capture. One specifically hard challenge is to estimate cross-frequency synchronization between broadband signals when no a priori hypothesis is available about the frequencies involved in the synchronization. Methods In the present manuscript, we expand upon the phase linearity measurement, an iso-frequency synchronization metrics previously developed by our group, in order to provide a conceptually similar approach able to detect the presence of cross-frequency synchronization between any components of the analyzed broadband signals. Results The methodology has been tested on both synthetic and real data. We first exploited Gaussian process realizations in order to explore the properties of our new metrics in a synthetic case study. Subsequently, we analyze real source-reconstructed data acquired by a magnetoencephalographic system from healthy controls in a clinical setting to study the performance of our metrics in a realistic environment. Conclusions In the present paper we provide an evolution of the PLM methodology able to reveal the presence of cross-frequency synchronization between broadband data.
- Published
- 2019
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