Author: "Grolleau A" / Publisher: hal ccsd - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"Grolleau A"' showing total 390 results

Start Over Author "Grolleau A" Publisher hal ccsd

390 results on '"Grolleau A"'

1. Personalization of renal replacement therapy initiation: a secondary analysis of the AKIKI and IDEAL-ICU trials

Author: François Grolleau, Raphaël Porcher, Saber Barbar, David Hajage, Abderrahmane Bourredjem, Jean-Pierre Quenot, Didier Dreyfuss, Stéphane Gaudry, Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer (LabEx LipSTIC), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut Gustave Roussy (IGR)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM)-Fédération Francophone de la Cancérologie Digestive, FFCD-Etablissement français du sang [Bourgogne-Franche-Comté] (EFS [Bourgogne-Franche-Comté])-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Hôpital Louis Mourier - AP-HP [Colombes], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée (CoRaKID), Hôpital Avicenne [AP-HP], and Porcher, Raphaël more...
Subjects: Intensive Care Units, Renal replacement therapy, [MATH.MATH-ST]Mathematics [math]/Statistics [math.ST], [SDV.MHEP.PHY] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Critical Care and Intensive Care Medicine, Kidney, Heterogeneity of treatment effect, Personalized medicine, [MATH.MATH-ST] Mathematics [math]/Statistics [math.ST], Time-to-Treatment, Acute kidney injury
Abstract: Background Trials comparing early and delayed strategies of renal replacement therapy in patients with severe acute kidney injury may have missed differences in survival as a result of mixing together patients at heterogeneous levels of risks. Our aim was to evaluate the heterogeneity of treatment effect on 60-day mortality from an early vs a delayed strategy across levels of risk for renal replacement therapy initiation under a delayed strategy. Methods We used data from the AKIKI, and IDEAL-ICU randomized controlled trials to develop a multivariable logistic regression model for renal replacement therapy initiation within 48 h after allocation to a delayed strategy. We then used an interaction with spline terms in a Cox model to estimate treatment effects across the predicted risks of RRT initiation. Results We analyzed data from 1107 patients (619 and 488 in the AKIKI and IDEAL-ICU trial respectively). In the pooled sample, we found evidence for heterogeneous treatment effects (P = 0.023). Patients at an intermediate-high risk of renal replacement therapy initiation within 48 h may have benefited from an early strategy (absolute risk difference, − 14%; 95% confidence interval, − 27% to − 1%). For other patients, we found no evidence of benefit from an early strategy of renal replacement therapy initiation but a trend for harm (absolute risk difference, 8%; 95% confidence interval, − 5% to 21% in patients at intermediate-low risk). Conclusions We have identified a clinically sound heterogeneity of treatment effect of an early vs a delayed strategy of renal replacement therapy initiation that may reflect varying degrees of kidney demand-capacity mismatch. more...
Published: 2022
Full Text: View/download PDF

2. Étude expérimentale et numérique des propriétés hors-équilibre de métaux dans le régime dense et tiède à l'échelle femtoseconde

Author: Grolleau, Adrïan, Centre d'Etudes Lasers Intenses et Applications (CELIA), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux, and Fabien Dorchies more...
Subjects: Molybdenum, [PHYS.PHYS]Physics [physics]/Physics [physics], Laser, Transition metal, Molybdène, Métal de transition, Pump probe, Pompe sonde, Matière dense et tiède, Warm dense matter
Abstract: The irradiation of materials using a femtosecond infrared laser brings matter in the so called warm dense matter regime, a frontier between solid state physics and plasma physics. At such a short timescale, an out-of-equilibrium situation occurs, where a great amount of energy is deposited on electrons, while the ions remains cold. This out-of-equilibrium regime may induce strong changes in the properties of the matter. This study focus on two different metals in the warm dense matter regime, copper and molybdenum. These metals have been studied experimentally using time-resolved X-ray absorption near edge spectroscopy (XANES), and numerically using ab initio simulations and hydrodynamics simulations. These simulations allow us to study matter respectively at the atomic scale through the electronic and ionic structures, and to the macroscopic scale by describing the behaviors of electrons and ions subsequent to an energy deposition. Amongst others, these three tools have been used to study copper extensively in the out-of-equilibrium warm dense matter regime. In particular, a diagnostic for the electronic temperature in copper have been developed, based on XANES spectroscopy near the L3 edge and ab initio simulations. Using these results, we studied the dynamics of the electron temperature in laser-heated warm dense copper at the femtosecond timescale, and highlighted that, beyond a certain laser flux, the electron energy transport transport is dominated by thermal diffusion rather than ballistic electron transport. Then, we transposed the methodology to study warm dense matter on the molybdenum, chosen to be the prototype for the study of transition metals in this regime. Hydrodynamics simulations allow us to estimate the typical thermodynamical conditions of molybdenum after a femtosecond laser pulse interaction. Ab initio simulations have then be conducted on warm dense molybdenum. Specifics features in the XANES spectra near the L3 edge of molybdenum have been identified, linked to the electronic and atomic structures, and their changes in the warm dense matter regime correlated to the temperature and density conditions. Finally, a preliminary XANES experiment conducted on warm dense molybdenum showed that the cold XANES spectra is in good agreement with the results of the ab initio simulations. Moreover, it also showed that it is possible to observe the changes in the spectra of molybdenum expected by the simulations in the warm dense regime.; L’irradiation de matériaux par un faisceau laser infra-rouge de durée femtoseconde permet de porter la matière dans le régime dense et tiède, frontière entre la physique du solide et la physique des plasmas. Á une échelle de temps aussi courte, on provoque une situation hors-équilibre thermique, où une grande quantité d’énergie est déposée dans les électrons tandis que les ions restent froids. Ce fort déséquilibre peut alors provoquer de grandes modifications des propriétés de la matière. L’étude présentée ici se penche sur deux métaux différents dans le régime dense et tiède hors-équilibre, le cuivre et le molybdène. Ces métaux ont été étudiés expérimentalement en utilisant la spectroscopie d’absorption des rayons X près des seuils (XANES) résolue en temps, ainsi que des simulations numériques dites ab initio et hydrodynamiques. Ces dernières permettent respectivement d’étudier la matière à l’échelle atomique au travers des structures électronique et ionique, et à l’échelle macroscopique en décrivant le comportement des électrons et des ions suite à un dépôt d’énergie. En utilisant ces trois outils (parmi d’autres), le cuivre a beaucoup été étudié dans le régime dense et tiède hors-équilibre. Notamment, un diagnostic quantitatif de la température des électrons dans le cuivre a été développé dans le passé, basé sur la spectroscopie XANES au seuil L3 et des simulations ab initio. Dans la continuité de ce résultat, nous avons étudié le transport de l’énergie électronique dans le cuivre chauffé par laser à l’échelle femtoseconde, et mis en évidence que, au delà d’un certain flux laser, ce transport est dominé par la diffusion thermique plutôt que par le transport d’électrons balistiques. Ensuite, nous avons transposé la méthodologie d’étude de la matière dense et tiède sur le molybdène, choisi en tant que prototype de métal de transition pour les études dans ce régime. Des simulations hydrodynamiques nous ont permis d’estimer les conditions thermodynamiques caractéristiques du molybdène à la suite d’un chauffage par une impulsion laser femtoseconde. Ensuite, une batterie de simulations ab initio ont été conduites. Elles ont permis d’identifier des motifs spécifiques dans les spectres XANES au seuil L3 du molybdène, ses liens avec les structures électronique et atomique, et comment cela change dans le régime dense et tiède en fonction de la température et de la densité. Enfin, une expérience préliminaire de spectroscopie XANES sur le molybdène dense et tiède nous a montré que le spectre froid du molybdène expérimental est en très bon accord avec les résultats des simulations ab initio. De plus, cette expérience a aussi montré qu’il était possible d’observer expérimentalement les changements du spectre XANES attendus par les simulations sur le molybdène. more...
Published: 2022

Catalog

Books, media, physical & digital resources

See catalog results

3. Kidney Histopathology Can Predict Kidney Function in ANCA-Associated Vasculitides with Acute Kidney Injury Treated with Plasma Exchanges

Author: Nezam, Dorian, Porcher, Raphaël, Grolleau, François, Morel, Pauline, Titeca-Beauport, Dimitri, Faguer, Stanislas, Karras, Alexandre, Solignac, Justine, Jourde-Chiche, Noémie, Maurier, François, Sakhi, Hamza, El Karoui, Khalil, Mesbah, Rafik, Carron, Pierre Louis, Audard, Vincent, Ducloux, Didier, Paule, Romain, Augusto, Jean-François, Aniort, Julien, Tiple, Aurélien, Rafat, Cédric, Beaudreuil, Séverine, Puechal, Xavier, Gobert, Pierre, Massy, Ziad, Hanrotel, Catherine, Bally, Stéphane, Martis, Nihal, Durel, Cécile-Audrey, Desbuissons, Geoffroy, Godmer, Pascal, Hummel, Aurélie, Perrin, François, Neel, Antoine, de Moreuil, Claire, Goulenok, Tiphaine, Guerrot, Dominique, Grange, Steven, Foucher, Aurélie, Deroux, Alban, Cordonnier, Carole, Guilbeau-Frugier, Céline, Modesto-Segonds, Anne, Nochy, Dominique, Daniel, Laurent, Moktefi, Anissa, Rabant, Marion, Guillevin, Loïc, Regent, Alexis, Terrier, Benjamin, CHU Rouen, Normandie Université (NU), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Cité (UPCité), AURA Paris - Plaisance, CHU Amiens-Picardie, CHU Toulouse [Toulouse], Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital de la Conception [CHU - APHM] (LA CONCEPTION), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier Boulogne-sur-mer, and Centre Hospitalier Universitaire [Grenoble] (CHU) more...
Subjects: [STAT.AP]Statistics [stat]/Applications [stat.AP], animal structures, Nephrology, fungi, General Medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Background Data from the PEXIVAS trial challenged the role of plasma exchange (PLEX) in ANCA-associated vasculitides (AAV). We aimed to describe kidney biopsy from patients with AAV treated with PLEX, evaluate whether histopathologic findings could predict kidney function, and identify which patients would most benefit from PLEX. Methods We performed a multicenter, retrospective study on 188 patients with AAV and AKI treated with PLEX and 237 not treated with PLEX. The primary outcome was mortality or KRT at 12 months (M12). Results No significant benefit of PLEX for the primary outcome was found. To identify patients benefitting from PLEX, we developed a model predicting the average treatment effect of PLEX for an individual depending on covariables. Using the prediction model, 223 patients had a better predicted outcome with PLEX than without PLEX, and 177 of them had >5% increased predicted probability with PLEX compared with without PLEX of being alive and free from KRT at M12, which defined the PLEX-recommended group. Risk difference for death or KRT at M12 was significantly lower with PLEX in the PLEX-recommended group (−15.9%; 95% CI, −29.4 to −2.5) compared with the PLEX not recommended group (−4.8%; 95% CI, 14.9 to 5.3). Microscopic polyangiitis, MPO-ANCA, higher serum creatinine, crescentic and sclerotic classes, and higher Brix score were more frequent in the PLEX-recommended group. An easy to use score identified patients who would benefit from PLEX. The average treatment effect of PLEX for those with recommended treatment corresponded to an absolute risk reduction for death or KRT at M12 of 24.6%. Conclusions PLEX was not associated with a better primary outcome in the whole study population, but we identified a subset of patients who could benefit from PLEX. However, these findings must be validated before utilized in clinical decision making. more...
Published: 2022
Full Text: View/download PDF

4. Why companies might under‐communicate their efforts for sustainable development and what can be done?

Author: Alice Falchi, Gilles Grolleau, Naoufel Mzoughi, Ecole Supérieure des Sciences Commerciales d'Angers (ESSCA), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: green communication, sustainable innovations, greenhushing, Strategy and Management, Geography, Planning and Development, Management, Monitoring, Policy and Law, Business and International Management, green blushing, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), stakeholders, [SHS]Humanities and Social Sciences
Abstract: International audience; In contrast with the increasing green demands from various stakeholders, corporations might prefer green blushing, that is, deliberately avoiding communicating their efforts for sustainable development. Surprisingly, these companies make substantial green achievements, but decide not to communicate their greenness. Using a broad literature review on green blushing and a conceptual reasoning backed up by anecdotal evidence, we expose the likely consequences of under-communicating green achievements and develop several rationales that explain this apparent puzzle. We also propose that silent or timid corporations can make the best of two worlds, by taking advantage from communicating their greenness while avoiding its main pitfalls. We suggest practical ways to do it. more...
Published: 2022
Full Text: View/download PDF

5. Micro-drone autopilot architecture for efficient static scheduling

Author: Hattenberger, Gautier, Bonneval, Fabien, Ladeira, Matheus, Grolleau, Emmanuel, Ouhammou, Yassine, and Hattenberger, Gautier
Subjects: [SPI.AUTO] Engineering Sciences [physics]/Automatic, [INFO.INFO-RB] Computer Science [cs]/Robotics [cs.RO], [INFO.INFO-ES] Computer Science [cs]/Embedded Systems
Abstract: This paper presents the internal architecture of a Modifiable Off-the-Shelf open-source autopilot. We show starting from a set of functional and hardware requirements why most autopilots use as a core thread a main loop acting as a nonpreemptive static scheduler, reacting to external events, some solicited, some unsolicited (but expected). We explain how the type of bus used to communicate with the sensor impacts the nature of the events received from the sensors (solicited or not). We show that depending on the workload that a main loop iteration has to handle, the execution time of an iteration can be larger than the period, creating potential delays in the attitude correction. Finally, we explore the degrees of freedom that can be used to reduce the impact of these overloads by smoothing the periodic workload. more...
Published: 2022

6. Projection bias in environmental beliefs and behavioural intentions-An application to solar panels and eco-friendly transport

Author: Lisette Ibanez, Gilles Grolleau, Sophie Clot, University of Reading (UOR), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: weather JEL numbers: C91, projection bias, Management, Monitoring, Policy and Law, 050105 experimental psychology, [SHS]Humanities and Social Sciences, Projection bias, 0502 economics and business, D91, Relevance (law), D12, 0501 psychology and cognitive sciences, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, 050207 economics, JEL: Q - Agricultural and Natural Resource Economics • Environmental and Ecological Economics/Q.Q5 - Environmental Economics/Q.Q5.Q59 - Other, solar panels, experimental survey, 05 social sciences, Q59, Environmental economics, Survey experiment, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Environmentally friendly, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, JEL: D - Microeconomics/D.D1 - Household Behavior and Family Economics/D.D1.D12 - Consumer Economics: Empirical Analysis, General Energy, 13. Climate action, weather, transport, Psychology, environment
Abstract: The projection bias corresponds to the human tendency to project current preferences into the future as if present preferences will remain unchanged, omitting a range of external influences over the current preferences. We design a survey experiment to investigate the projection bias relevance on two environmentally friendly initiatives, namely solar panels and eco-friendly transport. We found that beliefs and behavioral intentions are subject to positive change when individuals are solicited a day when the weather is congruent with the proposed changes. We draw several policy and managerial implications for environmental issues. more...
Published: 2022
Full Text: View/download PDF

7. Research response to coronavirus disease 2019 needed better coordination and collaboration: a living mapping of registered trials

Author: Nguyen, van Thu, Riviere, Philippe, Ripoll, Pierre, Barnier, Julien, Vuillemot, Romain, Ravaud, Philippe, Boutron, Isabelle, Nma Consortium, Covid, Alawadhi, Solaf, Amer-Yahia, Sihem, Ávila, Camila, Bafeta, Aïda, Baudry, Julia, Bollig, Claudia, Bonnet, Hillary, Bouet, Marinette, Cabanac, Guillaume, Chaimani, Anna, Chavalarias, David, Chen, Yaolong, Chevance, Astrid, Cohen-Boulakia, Sarah, Coquery, Emmanuel, Conil, Françoise, Davidson, Mauricia, de Nale, Laura, Devane, Declan, Diard, Elise, Doreau, Bastien, Evrenoglou, Theodoros, Fabri, Alice, Feron, Gilles, Ferrand, Gabriel, Fezeu, Leopold, Fouet, Mathilde, El Chall, Lina Ghosn, Graña, Carolina, Grasselli, Giacomo, Grolleau, François, Hacid, Mohand-Said, Haddy, Loubna, Hansen, Camilla, Hohlfeld, Ameer, Hróbjartsson, Asbjørn, Julia, Chantal, Mavridis, Dimitris, Meerpohl, Joerg, Meyer, Brice, Naidoo, Nivantha, Oikonomidi, Theodora, Pienaar, Elizabeth, Quirke, Fiona, Rada, Gabriel, Riveros, Carolina, Sauvant, Marie, Schmucker, Christine, Toumani, Farouk, Tovey, David, Xia, Jun, Yu, Xuan, Zoletic, Emina, Zweigenbaum, Pierre, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), French Cochrane Centre, VisionsCarto, Laboratoire d'InfoRmatique en Image et Systèmes d'information (LIRIS), Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre Max Weber (CMW), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), BioInformatique (BioInfo), Laboratoire Interdisciplinaire des Sciences du Numérique (LISN), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Science des Données (SDD), Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre d'épidémiologie Clinique [Hôtel-Dieu], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Hôtel Dieu, COVID-NMA Consortium Team: Solaf Alawadhi , Sihem Amer-Yahia , Camila Ávila , Aïda Bafeta , Julia Baudry , Claudia Bollig , Hillary Bonnet , Isabelle Boutron , Marinette Bouet , Guillaume Cabanac , Anna Chaimani , David Chavalarias , Yaolong Chen , Astrid Chevance , Sarah Cohen-Boulakia , Emmanuel Coquery , Francoise Conil , Mauricia Davidson , Laura De Nale , Declan Devane , Elise Diard , Bastien Doreau , Theodoros Evrenoglou , Alice Fabri , Gilles Feron , Gabriel Ferrand , Leopold Fezeu , Mathilde Fouet , Lina Ghosn El Chall , Carolina Graña , Giacomo Grasselli , François Grolleau , Mohand-Said Hacid , Loubna Haddy , Camilla Hansen , Ameer Hohlfeld , Asbjørn Hróbjartsson , Chantal Julia , Dimitris Mavridis , Joerg J Meerpohl , Brice Meyer , Nivantha Naidoo , Van Nguyen Thu , Theodora Oikonomidi , Elizabeth Pienaar , Fiona Quirke , Gabriel Rada , Philippe Ravaud , Pierre Ripoll , Carolina Riveros , Philippe Rivière , Marie Sauvant , Christine Schmucker , Farouk Toumani , David Tovey , Romain Vuillemot , Jun Xia , Xuan Yu , Emina Zoletic , Pierre Zweigenbaum, ANR-20-COVI-0084,living-NMA-covid,Efficacités des interventions contre l'infection Covid-19 : une cartographie de la recherche dynamique et séries de méta-analyses en réseau dynamiques(2020), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Situated Interaction, Collaboration, Adaptation and Learning (SICAL), Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-École Centrale de Lyon (ECL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Université Lumière - Lyon 2 (UL2), Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM), Equipe 5 : METHODS - Méthodes de l’évaluation thérapeutique des maladies chroniques (CRESS - U1153), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire d'Informatique de Grenoble (LIG), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Epistemonikos Foundation, Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), German Cochrane Centre, University Medical Centre Freiburg, LEB Aquitaine Transfert-ADERA, Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA), Recherche d’Information et Synthèse d’Information (IRIT-IRIS), Institut de recherche en informatique de Toulouse (IRIT), Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse - Jean Jaurès (UT2J)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Toulouse 1 Capitole (UT1), Université Fédérale Toulouse Midi-Pyrénées, Université Toulouse III - Paul Sabatier (UT3), Institut des Systèmes Complexes - Paris Ile-de-France (ISC-PIF), Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Sorbonne Université (SU)-École polytechnique (X)-École normale supérieure - Cachan (ENS Cachan)-Université Paris 1 Panthéon-Sorbonne (UP1), Lanzhou University, CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Science des Données (SDD), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Evidence Synthesis Ireland, Cochrane Ireland, Centre for Evidence-Based Medicine Odense (CEBMO), Odense University Hospital (OUH), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital d'instruction des Armées Percy, Service de Santé des Armées, Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, SANOFI Recherche, COCHRANE SOUTH AFRICA, University of Ioannina, Freiburg University Medical Center, HRB Trials Methodology Research Network (HRB-TRMN), Cochrane Chile, University of Nottingham Ningbo [China], Information, Langue Ecrite et Signée (ILES), Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Université Lumière - Lyon 2 (UL2)-École Centrale de Lyon (ECL), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), École normale supérieure - Cachan (ENS Cachan)-Université Paris 1 Panthéon-Sorbonne (UP1)-École polytechnique (X)-Institut Curie [Paris]-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Base de Données (BD), Universitäts Klinikum Freiburg = University Medical Center Freiburg (Uniklinik), CCSD, Accord Elsevier, and École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS) more...
Subjects: [SDV] Life Sciences [q-bio], Clinical trial, Living mapping, Treatment, Meta-analysis, Prevention, [SDV]Life Sciences [q-bio], Systematic review, COVID-19
Abstract: International audience; BackgroundResearchers worldwide are actively engaging in research activities to search for preventive and therapeutic interventions against COVID-19. Our aim was to describe the planning of randomized controlled trials (RCTs) in terms of timing related to the course of the COVID-19 epidemic and research question evaluated.MethodWe performed a living mapping of RCTs registered in the WHO International Clinical Trials Registry Platform. We systematically search the platform every week for all RCTs evaluating preventive interventions and treatments for COVID-19 and created a publicly available interactive mapping tool at https://covid-nma.com to visualize all trials registered.ResultsBy August 12, 2020, 1,568 trials for COVID-19 were registered worldwide. Overall, the median ([Q1-Q3]; range) delay between the first case recorded in each country and the first RCT registered was 47 days ([33-67]; 15-163). For the 9 countries with the highest number of trials registered, most trials were registered after the peak of the epidemic (from 100% trials in Italy to 38% in the United States). Most trials evaluated treatments (1,333 trials; 85%); only 223 (14%) evaluated preventive strategies and 12 post-acute period intervention. A total of 254 trials were planned to assess different regimens of hydroxychloroquine with an expected sample size of 110,883 patients.ConclusionThis living mapping analysis showed that COVID-19 trials have relatively small sample size with certain redundancy in research questions. Most trials were registered when the first peak of the pandemic have passed. more...
Published: 2021
Full Text: View/download PDF

8. Le recours aux métriques et aux nombres présente des revers souvent ignorés ou sous-estimés

Author: Asselineau, Alexandre, Grolleau, Gilles, Mzoughi, Naoufel, Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SHS]Humanities and Social Sciences
Abstract: Article dans le journal Le Monde (https://www.lemonde.fr/idees/article/2021/09/27/sciences-le-recours-aux-metriques-et-aux-nombres-presente-des-revers-souvent-ignores-ou-sous-estimes_6096140_3232.html); International audience more...
Published: 2021

9. Keeping up with the Joneses: Examining relative concerns in health-related domains

Author: Celse, Jerémy, Grolleau, Gilles, ESSCA School of Management (UER Economics, Law & Society), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: health outcomes, health economics, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, positional concerns, relative position, [SHS]Humanities and Social Sciences
Abstract: International audience; People are willing to engage resources to be above others. The existing evidence suggests that health is a non-positional good: people prefer to be healthy even if others are healthier than them. Using a survey-based study, we explore the positionality of several health-related dimensions in a Choice versus Happiness treatment. Most participants exhibit egalitarian preferences, namely they take into account others’ situations but prefer everybody to receive the same amount of health attributes. Moreover, when health attributes are related to physical appearance, participants express significantly higher levels of positional preferences. We draw several policy implications. more...
Published: 2021

10. Is theft considered less severe when the victim is a foreign company?

Author: Naoufel Mzoughi, Gilles Grolleau, Hind Dib-Slamani, MDI Algiers Business School, University of International Business and Economics [Beijing, China], Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: foreign companies, social identity, 05 social sciences, Group behavior, ComputingMilieux_LEGALASPECTSOFCOMPUTING, Criminology, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, General Business, Management and Accounting, cultural factors, group behavior, 050105 experimental psychology, Disadvantaged, [SHS]Humanities and Social Sciences, 0502 economics and business, 0501 psychology and cognitive sciences, Business, Social identity theory, 050203 business & management, Finance, discrimination
Abstract: International audience; The moral judgment of theft against a company is related to the company origin, but all origins are not created equal. Foreign companies are not systematically disadvantaged compared to domestic ones. Foreign companies from in-group origins could be at an advantage compared to similar foreign companies from out-group origins. A theft is judged more leniently when the victim is from the out-group than one from the in-group. more...
Published: 2021
Full Text: View/download PDF

11. A Good Servant But a Poor Master: The Side Effects of Numbers and Metrics

Author: Gilles Grolleau, Alexandre Asselineau, Naoufel Mzoughi, Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: Marketing, Public Administration, Sociology and Political Science, Presumption, 05 social sciences, 050109 social psychology, Dehumanization, 0506 political science, [SHS]Humanities and Social Sciences, metrics, surrogation bias, numbers, 050602 political science & public administration, dehumanization, Servant, 0501 psychology and cognitive sciences, Public service, Sociology, measurement, Law and economics
Abstract: International audience; A common practice in managerial and public service contexts is to quantity, calculate, and use numbers and metrics which provide a presumption of scientificity, a sense of measurability, objectivity, reliability, and precision upon which smarter decisions can be made. Besides providing a theoretical background, we analyze counter-productive effects of over-relying on numbers and metrics, notably in public administration. We discuss the following traps: preferring what is measurable over what is important, replacing the strategy by a measure and dehumanizing the decision making. We suggest some practical ways to facilitate a more parsimonious, smarter, and adequate use of numbers. more...
Published: 2021
Full Text: View/download PDF

12. Analysis of T‐cell responses directed against the spike and/or membrane and/or nucleocapsid proteins in patients with chilblain‐like lesions during the COVID‐19 pandemic

Author: Assia Samri, Jean-David Bouaziz, P. Moghadam, Olivier Schwartz, Nader Yatim, D. Bergerat, C. Delaugerre, Martine Bagot, Jérôme LeGoff, C. Grolleau, Laure Frumholtz, Charles Cassius, L. Jaume, H. Le Buanec, Ludivine Grzelak, M. Merandet, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Virus et Immunité - Virus and immunity (CNRS-UMR3569), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Immunologie Translationnelle - Translational Immunology lab, Saint-Louis CORE (COvid REsearch), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut Pasteur [Paris], Virus et Immunité - Virus and immunity, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), and Le Buanec, Hélène more...
Subjects: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), T-Lymphocytes, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), T cell, [SDV]Life Sciences [q-bio], Dermatology, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Pandemic, Research Letter, medicine, Humans, Pandemics, Nucleocapsid Proteins, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, business.industry, COVID-19, Virology, 3. Good health, Chilblains, [SDV] Life Sciences [q-bio], medicine.anatomical_structure, Spike Glycoprotein, Coronavirus, Spike (software development), business
Abstract: International audience; No abstract available
Published: 2021
Full Text: View/download PDF

13. Routine Molecular Screening of Patients with Advanced Non-SmallCell Lung Cancer in Circulating Cell-Free DNA at Diagnosis and During Progression Using OncoBEAMTM EGFR V2 and NGS Technologies

Author: Garcia, Jessica, Gauthier, Arnaud, Lescuyer, Gaëlle, Barthelemy, David, Geiguer, Florence, Balandier, Julie, Edelstein, Daniel, Jones, Frederick, Holtrup, Frank, Duruisseau, Mickael, Grolleau, Emmanuel, Rodriguez-Lafrasse, Claire, Merle, Patrick, Couraud, Sébastien, Payen, Léa, Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand, Hospices Civils de Lyon (HCL), and Sysmex Inostics GmBH more...
Subjects: [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract: International audience; Background and objectives: The use of ultra-sensitive diagnostic tests to detect clinically actionable somatic alterations within the gene encoding the epidermal growth factor receptor (EGFR) within circulating cell-free DNA is an important first step in determining the eligibility of patients with non-small cell lung cancer to receive tyrosine kinase inhibitors.Methods: We present the clinical validation (accuracy, sensitivity, and specificity) of a highly sensitive OncoBEAMTM EGFR V2 test, which we compare to a custom next-generation sequencing assay, for the treatment of patients with non-small cell lung cancer with EGFR tyrosine kinase inhibitor therapies. The OncoBEAMTM digital-polymerase chain reaction method detects 36 different EGFR alterations in circulating cell-free DNA, whereas the next-generation sequencing assay covers major solid tumor oncodrivers. Of the 540 samples analyzed with the OncoBEAMTM EGFR V2 test, 42.4% of patients had undergone molecular testing at diagnosis (N = 229/540) and 57.7% of patients during disease progression (N = 311/540).Results: The sensitivity and specificity were measured for this BEAMing assay. The number of mutant beads and mutant allelic fraction were measured for each EGFR alteration and the level of detection was established at 0.1% for a median of 2861 genome equivalent (GE) in each reaction using HD780 horizon control DNA, as well as by an internal quality reference standard. Approximately 10%, 27%, and 63% of the 540 samples contained < 1500 GE, a range of 1500-3000 GE, and > 3000 GE, which corresponded to a maximal assay sensitivity of 2.0%, 0.5-0.1%, and 0.1-0.05% mutant allelic fraction, respectively. In a routine hospital setting, 11.4% of non-small cell lung cancer tumors were positive at diagnosis for EGFR alterations, while 43.7% samples harbored EGFR mutations at progression, among which 40.3% expressed EGFR resistance mutations after first-line tyrosine kinase inhibitor treatment with first- and second-generation drugs.Conclusions: The OncoBEAMTM EGFR V2 is a sensitive, robust, and accurate assay that delivers reproducible results. Next-generation sequencing and BEAMing technologies act complementarily in the routine molecular screening. We show that using a next-generation sequencing assay, despite its lower sensitivity, enables the identification of rare EGFR alterations or resistance mechanisms (mutation, deletion, insertion, and copy number variation) to orient first- and second-line treatments. more...
Published: 2021
Full Text: View/download PDF

14. How relative concerns affect unethical behaviors

Author: Latifa Barbara, Gilles Grolleau, Naoufel Mzoughi, MDI Alger Business School, Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: Economics and Econometrics, behavior, 05 social sciences, 050109 social psychology, 16. Peace & justice, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, General Business, Management and Accounting, ethics, position, Algeria, 0502 economics and business, 0501 psychology and cognitive sciences, survey, France, 050207 economics, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; We analyze positional concerns in the unethical domain. We introduce an original distinction between "selective" positionality-where individuals prefer behaving unethically but to a lesser extent than peers-and "ego" positionality-where they prefer behaving unethically but to a higher extent than peers, regardless of the absolute level. We also report the results of an exploratory survey in Algeria that exploits the counterintuitive insight that people are better at predicting others' behaviors than their own behaviors. We increase the finding's generalizability by conducting the same survey among a similar sample in France. Our findings are twofold: first, the majority of participants attributes to others preferences for ethical (i.e., where everyone is honest) and unethical egalitarian (where all are similarly dishonest) situations. Second, a non-negligible proportion of respondents attributes to the average individual preferences for either selective or ego-positionality in unethical behaviors. more...
Published: 2021
Full Text: View/download PDF

15. Projection bias in environmental beliefs and behavioural intentions

Author: Clot, Sophie, Grolleau, Gilles, Ibanez, Lisette, University of Reading (UOR), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: experimental survey, weather JEL numbers: C91, projection bias, Q59, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, [SHS]Humanities and Social Sciences, JEL: D - Microeconomics/D.D1 - Household Behavior and Family Economics/D.D1.D12 - Consumer Economics: Empirical Analysis, weather, transport, D91, D12, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, JEL: Q - Agricultural and Natural Resource Economics • Environmental and Ecological Economics/Q.Q5 - Environmental Economics/Q.Q5.Q59 - Other, environment, solar panels
Abstract: International audience; The projection bias corresponds to the human tendency to project current preferences into the future as if present tastes remained unchanged. We apply the projection bias to the environmental domainand design a surveyexperiment to investigate its relevance on two environmentally friendly initiatives, namelysolar panels and eco-friendly transport. We found that some attitudes and behavioral intentions aresubject to positive changewhen individuals are soliciteda day when the weatheris congruent with the proposed changes. We draw several policy and managerial implications for ecological issues. more...
Published: 2021

16. Does a company’s origin matter in moral judgment?

Author: Naoufel Mzoughi, Gilles Grolleau, Hind Dib-Slamani, University of International Business and Economics [Beijing, China], MDI Algiers Business School, Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: experimental survey, Economics and Econometrics, liability of foreignness (LOF), Strategy and Management, JEL: F - International Economics/F.F2 - International Factor Movements and International Business/F.F2.F23 - Multinational Firms • International Business, 05 social sciences, Liability, business ethics, 16. Peace & justice, moral judgment, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, General Business, Management and Accounting, [SHS]Humanities and Social Sciences, 0502 economics and business, Corporate social responsibility, 050211 marketing, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, Business, Business and International Management, Business ethics, Social identity theory, CSR, 050203 business & management, Law and economics
Abstract: We blend the institutional and social identity theories to explain why foreign companies may endure a differentiated treatment compared to domestic ones. We extend the “liability of foreignness” (LOF) reasoning to the moral domain. Using a survey experiment in Algeria and France, we examine whether observers judge similarly or differently the same ethical and unethical practices by manipulating the doers’ origin. Each treatment corresponds to a specific combination of company behavior (ethical vs. unethical) and company origin (no origin mentioned vs. domestic origin vs. foreign origin). We found that company origin matters for the ethical and some unethical scenarios. However, the foreignness consequences in the moral domain are not always consistent with a simplistic application of LOF-based arguments, leading us to consider a more complex picture than initially expected. In the Algerian sample, we found that foreign companies can even benefit from an advantage compared to domestic ones. JEL CLASSIFICATION F23; C91 more...
Published: 2021
Full Text: View/download PDF

17. Does misery love company? An experimental investigation

Author: Katherine Farrow, Lisette Ibanez, Gilles Grolleau, EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Economie de l'Environnement - Montpellier (CEE-M), Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut Agro Montpellier, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Montpellier (UM), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and GARNIER, Laurent more...
Subjects: Economics and Econometrics, JEL: I - Health, Education, and Welfare/I.I3 - Welfare, Well-Being, and Poverty/I.I3.I31 - General Welfare, Well-Being, media_common.quotation_subject, 050109 social psychology, Sample (statistics), Conventional wisdom, [SHS]Humanities and Social Sciences, Adage, well-being, Phenomenon, 0502 economics and business, 0501 psychology and cognitive sciences, positional preferences, I31, 050207 economics, Marketing, [SHS.ECO] Humanities and Social Sciences/Economics and Finance, social norms, JEL: D - Microeconomics/D.D6 - Welfare Economics/D.D6.D60 - General, media_common, Social comparison theory, 05 social sciences, social information JEL codes: C90, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, social information, D60, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C90 - General, Well-being, Happiness, National wealth, [SHS] Humanities and Social Sciences, D03, Psychology
Abstract: The conventional wisdom summarized in the adage ‘misery loves company’ suggests that suffering can be made easier to bear if it is also shared by others. Given increasing interest in subjective well-being and happiness as constituents of national wealth and priorities in policy-making and organizational management, we empirically investigate the validity of this phenomenon in order to explore whether it may be possible to mitigate decreases in subjective well-being simply by leveraging social comparison. We implement an experimental survey designed to gauge the suitability of this strategy on a representative sample of approximately 2,000 US residents. Our results indicate that, while this hypothesis is indeed borne out among certain populations within the sample, we find stronger and more widespread support for the opposite phenomenon, suggesting rather that ‘happiness hates company’. These novel findings can inform policy interventions aiming to enhance well-being and point to promising avenues for further work. more...
Published: 2021

18. Lower limb perforator flaps: Current concept

Author: Benoit Chaput, Christian Herlin, Farid Bekara, Thomas Meresse, Silvia Gandolfi, Jean-Louis Grolleau, D. Gangloff, Hôpital de Rangueil, CHU Toulouse [Toulouse], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Rouen, Normandie Université (NU), Aide à la Décision pour une Médecine Personnalisé - Laboratoire de Biostatistique, Epidémiologie et Recherche Clinique - EA 2415 (AIDMP), and Université Montpellier 1 (UM1)-Université de Montpellier (UM) more...
Subjects: medicine.medical_specialty, Vascular anatomy, Computer science, Lower limb flaps, MESH: Lower Extremity, Lambeaux en hélice, Free flap, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, 030230 surgery, Lower limb, 03 medical and health sciences, 0302 clinical medicine, Long period, medicine, Humans, Lambeaux perforants, MESH: Perforator Flap, MESH: Humans, eye diseases, Propeller flaps, Surgery, Lower Extremity, Perforator flaps, Membres inférieurs, Reconstruction, Perforator Flap
Abstract: International audience; Following a long period dominated by random fasciocutaneous flaps or muscle flaps, solutions to cover the lower limb have been largely diversified by the advent of so-called "perforator" flaps. Extended knowledge of vascular anatomy has propagated the development of this innovative procedure, in the objective of reducing morbidity. The existence of close to 400 perforator vessels in the body makes it possible to offer new flap perspectives for many defects, which were sometimes previously impossible to manage before except by free flap. For us, perforator flaps have become the current first-line solutions for small to medium size loss of substances. Understanding of vascular physiology and surgical experience are essential in choosing indications, detecting perforators, and modeling flaps to be optimally positioned in the reconstructive decisional algorithm. New skills are needed to master this type of reconstruction and limit failures, which implies a learning curve not only for flap design, perforator detection and surgical procedure, but also for monitoring and management of complications. In this manuscript, we outline the concepts and principles of the majority of the pedicled perforator flaps available for coverage of the lower limb, based on experience of more than 400 perforator flaps suitable for this localization. more...
Published: 2020
Full Text: View/download PDF

19. Robbing a robber is not robbing

Author: Gilles Grolleau, Naoufel Mzoughi, Hind Dib-Slamani, University of International Business and Economics [Beijing, China], MDI Algiers Business School, Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: Ethics, Economics and Econometrics, 050208 finance, Victims, media_common.quotation_subject, 05 social sciences, Judgement, Criminology, 16. Peace & justice, Robbers, [SHS]Humanities and Social Sciences, Extension (metaphysics), Bankers, Custom officials, Robbing, Experimental survey, 0502 economics and business, Sociology, 050207 economics, Finance, Reputation, media_common
Abstract: International audience; Do outside observers judge differently an identical act of robbery if the victim is known as a robber rather than an honest individual? Popular wisdom, as magnified in several proverbs, suggests that most people do. We examine such a tenet using an experimental survey in Algeria (North-Africa). We also examine whether a differentiated moral judgement holds for two occupations tarnished with the reputation of robbing consumers, namely bankers and customs officials. Our findings support the proverb that ‘robbing a robber is not robbing’ and even its extension to custom officials. However, robbing a banker has not been found to be significantly different from robbing an honest individual. We draw several business and policy implications. more...
Published: 2020
Full Text: View/download PDF

20. Scandals : a ‘reset button’ to drive change?

Author: Grolleau, Gilles, Marciano, Alain, Mzoughi, Naoufel, Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Montpellier Recherche en Economie (MRE), Université de Montpellier (UM), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Article, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract: International audience
Published: 2020
Full Text: View/download PDF

21. Fold-stratified cross-validation for unbiased and privacy-preserving federated learning

Author: Mehdi Benchoufi, Romain Bey, Romain Goussault, François Grolleau, Raphaël Porcher, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre hospitalier universitaire de Nantes (CHU Nantes), and Porcher, Raphaël more...
Subjects: FOS: Computer and information sciences, Computer Science - Machine Learning, Computer science, Hash function, Machine Learning (stat.ML), Health Informatics, computer.software_genre, Research and Applications, privacy, Cross-validation, Synthetic data, Machine Learning (cs.LG), Methodology (stat.ME), Machine Learning, 03 medical and health sciences, 0302 clinical medicine, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], Statistics - Machine Learning, Data Anonymization, Covariate, Data deduplication, Electronic Health Records, Humans, 030212 general & internal medicine, Pseudonymization, Statistics - Methodology, Computer Security, 030304 developmental biology, validation, 0303 health sciences, federated learning, Medical record, [STAT.ML] Statistics [stat]/Machine Learning [stat.ML], Identifier, data leakage, Data mining, computer, Algorithms, Confidentiality, duplicated electronic health records
Abstract: Large-scale collections of electronic records constitute both an opportunity for the development of more accurate prediction models and a threat for privacy. To limit privacy exposure new privacy-enhancing techniques are emerging such as federated learning which enables large-scale data analysis while avoiding the centralization of records in a unique database that would represent a critical point of failure. Although promising regarding privacy protection, federated learning prevents using some data-cleaning algorithms thus inducing new biases. In this work we focus on the recurrent problem of duplicated records that, if not handled properly, may cause over-optimistic estimations of a model's performances. We introduce and discuss stratified cross-validation, a validation methodology that leverages stratification techniques to prevent data leakage in federated learning settings without relying on demanding deduplication algorithms., 13 pages, 5 figures more...
Published: 2020
Full Text: View/download PDF

22. New Metal Complexes with Salen-type Ligands

Author: Paolo Biagini, Riccardo Po, Jérémie Grolleau, Antoine Labrunie, Clément Cabanetos, Jean Roncali, Philippe Blanchard, MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), ENI, and BLANCHARD, Philippe more...
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry
Published: 2020

23. Projection bias in environmental attitudes and behavioral intentions

Author: Clot, Sophie, Grolleau, Gilles, Ibanez, Lisette, University of Reading (UOR), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: experimental survey, JEL: D - Microeconomics/D.D1 - Household Behavior and Family Economics/D.D1.D12 - Consumer Economics: Empirical Analysis, projection bias, transport, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, JEL: Q - Agricultural and Natural Resource Economics • Environmental and Ecological Economics/Q.Q5 - Environmental Economics/Q.Q5.Q59 - Other, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, environment, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, solar panels, [SHS]Humanities and Social Sciences
Abstract: The projection bias corresponds to the human tendency to project current preferences into the future as if present tastes remained unchanged. We apply the projection bias to the environmental domain and design a survey experiment to investigate its relevance on two environmentally friendly initiatives, namely solar panels and eco-friendly transport. We found that some attitudes and behavioral intentions are subject to positive change when individuals are solicited a day when the weather is congruent with the proposed changes. We draw several policy and managerial implications for ecological issues. more...
Published: 2020

24. Does aversion to the sucker's payoff matter in public goods games?

Author: Douadia Bougherara, Sandrine Costa, Gilles Grolleau, Lisette Ibanez, UMR 1302 Structures et Marchés Agricoles, Ressources et Territoires, Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Structures et Marchés Agricoles, Ressources et Territoires (SMART), Laboratoire Montpelliérain d'Économie Théorique et Appliquée (LAMETA), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro), Laboratoire d'Economie Forestière (LEF), AgroParisTech-Institut National de la Recherche Agronomique (INRA), auto-saisine, Absent, Structures et Marchés Agricoles, Ressources et Territoires, Institut National de la Recherche Agronomique (INRA), Association Française de Science Economique (AFSE). FRA., Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut National de la Recherche Agronomique (INRA)-AGROCAMPUS OUEST-Structures et Marchés Agricoles, Ressources et Territoires (SMART) more...
Subjects: [SDV.SA]Life Sciences [q-bio]/Agricultural sciences, jel:C91, experiment, économie, public good, suckers payoff, assurance, [SDV]Life Sciences [q-bio], jel:C72, jel:H41, Economies et finances, Economies and finances, expériment, INSURANCE, bien public, Experiments, Public good, Sucker’s payoff, Assurance, PUBLIC GOOD, SUCKERS PAYOFF, expérimentation
Abstract: A usual explanation to low levels of contribution to public goods is the fear of getting the sucker’s payoff (cooperation by the participant and defection by the other players). In order to disentangle the effect of this fear from other motives, we design a public good game where people have an assurance against getting the sucker’s payoff. We show that contributions to the public good under this ‘protective’ design are significantly higher and interact with expectations on other individuals’ contribution to the public good. Some research extensions are suggested., Une des raisons à la faible contribution volontaire aux biens publics est l’aversion au sucker’s payoff (coopération individuelle quand les autres font défection). Afin de distinguer l’effet de cette aversion d’autres causes, nous réalisons une expérience de contribution à un bien public dans laquelle les joueurs ont une assurance contre le risque de sucker’s payoff. Les résultats montrent que l’assurance augmente les contributions de manière directe mais également de manière indirecte à travers les anticipations des individus sur les contributions des autres. more...
Published: 2020

25. On signaling disability in anonymous economic games

Author: Gilles Grolleau, Rodolphe Perchot, Angela Sutan, Sylvain Max, Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Régional Supérieur du Travail Educatif et Social de Bourgogne (IRTESS), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: Economics and Econometrics, Sociology and Political Science, Ultimatum game, 05 social sciences, Disabled people, Permanent disability, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 050105 experimental psychology, Salient, 0502 economics and business, Dictator, 0501 psychology and cognitive sciences, 050207 economics, 10. No inequality, Psychology, Social psychology, Applied Psychology, ComputingMilieux_MISCELLANEOUS
Abstract: We experimentally tested whether individuals behave differently when they interact with other individuals whose disability is salient in dictator and ultimatum games. We found that participants are more generous and fairer with disabled people, and that this behavior is not strategic. These effects are driven by the specific nature of the disability not by the difference per se. The evidence regarding the effect of acquired versus permanent disability is mixed. Practitioner points: • People interact in a positive way with disabled people. • Managers can be tempted to use strategically disabled people in organizational contexts. more...
Published: 2020
Full Text: View/download PDF

26. The Reference Point Bias in Judging Cheaters

Author: Clot, Sophie, Grolleau, Gilles, Ibanez, Lisette, University of Reading (UOR), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: experimental survey, reference points, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, JEL: K - Law and Economics/K.K4 - Legal Procedure, the Legal System, and Illegal Behavior/K.K4.K42 - Illegal Behavior and the Enforcement of Law, moral judgment, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ethics
Abstract: Do observers judge differently a wrongdoer when s/he does not exploit the situation to its maximum extent? Using a social intuitionist perspective and taking into account the reference point bias, we hypothesize that people will judge less severely a moral wrongdoing when the situation is not exploited to its fullest extent. Thanks to an experimental survey in France, we examine whether various wrongdoings performed in the business realm (overcharging travel expenses, overstating work hours, pollution) are judged less severely when differing reference points are suggested: (i) no explicit reference point is mentioned, (ii) the maximum extent is reached, (iii) the maximum extent is not reached. Our findings support that participants judge less severely a wrongdoer, when it is indicated that s/he has not exploited the situation to its fullest extent. In addition of maintaining their self-concepts, our findings suggest that partial cheaters can also emphasize their self-restraint to mitigate judgement and punishment if they get caught. We draw some managerial and policy implications. more...
Published: 2020

27. Coopetition in innovation activities and firms' economic performance: An empirical analysis

Author: Naoufel Mzoughi, Gilles Grolleau, Sanja Pekovic, University of Montenegro (UCG), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) more...
Subjects: Estimation, Earnings before interest, taxes, depreciation, and amortization, Earnings, Amortization (business), Strategy and Management, Depreciation, 05 social sciences, Coopetition, development cooperation, financial performance, Management of Technology and Innovation, 8. Economic growth, 0502 economics and business, Ordinary least squares, Survey data collection, [SHS.GESTION]Humanities and Social Sciences/Business administration, 050211 marketing, Business, 050203 business & management, Industrial organization
Abstract: We use survey data to test whether it pays to cooperate in innovation activities with rivals (also referred to as coopetition) compared to other cooperative arrangements, notably with non-rival partners. Applying an ordinary least squares regression to a large sample of French firms (N = 2957), we found evidence of a positive and significant relationship between various forms of cooperation (with and without rivals) and firms' economic performance, measured by EBITDA (earnings before interest, taxes, depreciation and amortization). Results show that cooperation with rival and non-rivals taken together increases economic performance, but that the impact of cooperation with rivals is lower than the impact of cooperation with non-rivals. Estimation results suggest that reaping the full cooperation benefits is not automatic and requires precision dosing and management. more...
Published: 2020
Full Text: View/download PDF

28. Is a 'bad individual' more condemnable than several 'bad individuals'? Examining the scope-severity paradox

Author: Lisette Ibanez, Naoufel Mzoughi, Gilles Grolleau, Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de la Recherche Agronomique (INRA), ANR-15-CE05-0008,GREENGO,Nouveaux instruments de gouvernance pour la transition énergétique : le rôle des ONG(2015), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: punishment, Punishment, media_common.quotation_subject, identifiability bias, 050105 experimental psychology, wrongdoing, Phenomenon, Wrongdoing, 0502 economics and business, 0501 psychology and cognitive sciences, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, 050207 economics, Empirical evidence, media_common, crime, Scope (project management), 05 social sciences, 16. Peace & justice, Survey experiment, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, Perceived harm, scope-severity paradox, Psychology, Law, General Economics, Econometrics and Finance, Financial fraud, Social psychology
Abstract: Previous literature found empirical evidence to the scope-severity paradox (SSP), corresponding to situations where the perceived harm of a wrongdoing or crime decreases with the number of victims. We examine this phenomenon for the perpetrators’ side. Using a survey experiment, we examine whether increasing the number of perpetrators of a crime, namely a fraud, decreases its perceived severity (and subsequent punishment) at the individual level. Two scenarios are examined corresponding to two kinds of fraud: a fraud committed by a financial adviser against his/her own employer (scenario 1) and a tax evasion by an executive (scenario 2). Overall, our results do not offer a clear-cut support for the scope-severity paradox for the perpetrators’ side, even if some secondary results can be indicative of a possible SSP in some circumstances. More precisely, in the case of a financial fraud, the stated severity increases when the number of perpetrators is low. We discuss the implications of our results and raise important issues for future research. more...
Published: 2020
Full Text: View/download PDF

29. Moral judgment of environmental harm caused by a single versus multiple wrongdoers: A survey experiment

Author: Gilles Grolleau, Lisette Ibanez, Naoufel Mzoughi, Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), ANR-15-CE05-0008,GREENGO,Nouveaux instruments de gouvernance pour la transition énergétique : le rôle des ONG(2015), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut National de la Recherche Agronomique (INRA), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) more...
Subjects: Economics and Econometrics, punishment, 010504 meteorology & atmospheric sciences, Punishment, Collateral, media_common.quotation_subject, Context (language use), 010501 environmental sciences, 01 natural sciences, Empirical research, Phenomenon, Wrongdoing, pollution, JEL: C - Mathematical and Quantitative Methods/C.C9 - Design of Experiments/C.C9.C91 - Laboratory, Individual Behavior, 0105 earth and related environmental sciences, General Environmental Science, media_common, food and beverages, 16. Peace & justice, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, JEL: D - Microeconomics/D.D9 - Intertemporal Choice/D.D9.D91 - Intertemporal Household Choice • Life Cycle Models and Saving, [SDE.ES]Environmental Sciences/Environmental and Society, Test (assessment), Harm, environmental wrongdoing, scope-severity paradox, Psychology, Social psychology
Abstract: International audience; Some experimental and archival studies have found empirical support for the scope-severity paradox (SSP), according to which the perceived harm of the same crime or wrongdoing decreases when the number of victims is greater. In the context of environmental wrongdoing, we investigate whether the SSP applies when the number of perpetrators of a crime or wrongdoing increases. Using a survey experiment with two scenarios and five treatments (variations of the number of perpetrators and the individual and total harms committed), we test whether the perceived severity and punishment recommendation for perpetrators of an environmental wrongdoing decrease as the number of perpetrators increases, independent of the total environmental harm committed. Unlike the studies that look at the SSP phenomenon as regards number of victims, we do not find direct support for the existence of a SSP effect regarding number of perpetrators. We do find, however, that participants evaluating the one-perpetrator treatments are more likely to judge with the highest severity. We also provide some collateral insights such as the insensitiveness of participants to the individual pollution level, once the environmental damage exceeds a certain threshold. Our results extend previous SSP studies in important directions and suggest some policy implications, and avenues for further research. more...
Published: 2020
Full Text: View/download PDF

30. Transfert des éléments libérés des anodes galvaniques dans le compartiment sédimentaire après une longue exposition en milieu portuaire et des essais en laboratoire

Author: Caplat, C., Basuyaux, O., Pineau, S., Deborde, J., Grolleau, A.M., Le Glatin, Stéphane, Mahaut, Marie Laure, Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Synergie MEr et Littoral (SMEL), ACCOAST, Naval Group, LABÉO, Pôle d’analyses et de recherche de Normandie (LABÉO), Institut national des sciences et techniques de la mer (INTECHMER), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), and HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM) more...
Subjects: [SDE]Environmental Sciences, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
Full Text: View/download PDF

31. Growth and differentiation factor 15 is secreted by skeletal muscle during exercise and promotes lipolysis in humans

Author: Julie Vion, Dominique Larrouy, Virginie Bourlier, Stéphane Blanc, I. Harant, Claire Laurens, Sylvie Caspar-Bauguil, Coralie Fontaine, Dominique Langin, Claire Thalamas, Pauline Maes, Marie Adeline Marques, Nathalie Viguerie, Isabelle de Glisezinski, Deborah Carper, Benjamin Lair, Emilie Montastier, Cedric Moro, Jean Louis Grolleau, Donal J. O’Gorman, Enda Murphy, Geneviève Tavernier, Fabrice Bertile, Anne Bouloumié, Nathalie Boulet, Anisha Parmar, Gaillard, Brigitte, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre d'investigation clinique de Toulouse (CIC 1436), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Pôle Santé publique et médecine publique [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Dublin City University [Dublin] (DCU), Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC), Institut de médecine moléculaire de Rangueil (I2MR), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Dublin City University (DCU), Ireland's university of Enterprise, and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-IFR150-Institut National de la Santé et de la Recherche Médicale (INSERM) more...
Subjects: 0301 basic medicine, Adult, Male, [SDE] Environmental Sciences, medicine.medical_specialty, Growth Differentiation Factor 15, Lipolysis, Adipose tissue, Stimulation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Myokine, medicine, Humans, Muscle, Skeletal, Exercise, Muscle biopsy, medicine.diagnostic_test, Myogenesis, Chemistry, Skeletal muscle, General Medicine, 030104 developmental biology, Endocrinology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, [SDE]Environmental Sciences, GDF15, Research Article
Abstract: International audience; We hypothesized that skeletal muscle contraction produces a cellular stress signal, triggering adipose tissue lipolysis to sustain fuel availability during exercise. The present study aimed at identifying exercise-regulated myokines, also known as exerkines, able to promote lipolysis. Human primary myotubes from lean healthy volunteers were submitted to electrical pulse stimulation (EPS) to mimic either acute intense or chronic moderate exercise. Conditioned media (CM) experiments with human adipocytes were performed. CM and human plasma samples were analyzed using unbiased proteomic screening and/or ELISA. Real-time qPCR was performed in cultured myotubes and muscle biopsy samples. CM from both acute intense and chronic moderate exercise increased basal lipolysis in human adipocytes. Growth and differentiation factor 15 (GDF15) gene expression and secretion increased rapidly upon skeletal muscle contraction. GDF15 protein was upregulated in CM from both acute and chronic exercise–stimulated myotubes. We further showed that physiological concentrations of recombinant GDF15 protein increased lipolysis in human adipose tissue, while blocking GDF15 with a neutralizing antibody abrogated EPS CM-mediated lipolysis. We herein provide the first evidence to our knowledge that GDF15 is a potentially novel exerkine produced by skeletal muscle contraction and able to target human adipose tissue to promote lipolysis. more...
Published: 2020
Full Text: View/download PDF

32. How to turn crowding-out into crowding-in? An innovative instrument and some law-related examples

Author: Charles Figuieres, Gilles Grolleau, Antoine Beretti, Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Aix-Marseille Sciences Economiques (AMSE), École des hautes études en sciences sociales (EHESS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Centre National de la Recherche Scientifique (CNRS), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), ANR-16-CE03-0005,GREEN-Econ,Vers une économie plus verte : politiques environnementales et adaptation sociétale(2016), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) more...
Subjects: crowding-out, Economics and Econometrics, media_common.quotation_subject, Commercial law, Outcome (game theory), Microeconomics, 0502 economics and business, Economics, JEL: D - Microeconomics/D.D6 - Welfare Economics/D.D6.D64 - Altruism • Philanthropy, 050207 economics, Business and International Management, JEL: Q - Agricultural and Natural Resource Economics • Environmental and Ecological Economics/Q.Q5 - Environmental Economics/Q.Q5.Q58 - Government Policy, media_common, 050208 finance, JEL: H - Public Economics/H.H2 - Taxation, Subsidies, and Revenue/H.H2.H23 - Externalities • Redistributive Effects • Environmental Taxes and Subsidies, 05 social sciences, Internalism and externalism, Payment, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Crowding out, Incentive, moral motivation, environmental regulation, heterogeneity, Law, Mechanism (sociology), Public finance, JEL: D - Microeconomics/D.D0 - General
Abstract: International audience; Using a simple decision-theoretic approach, we formalize how agents with different kinds of intrinsic motivations react to the introduction of monetary incentives. We contend that empirical results supporting the existence of a crowding-out effect under various legal procedures hide a more complex reality, where some individuals contribute thanks to these additional monetary incentives while others reduce their contributions. Our approach allows us to study the theoretical ability of the self selection mechanism (Mellström and Johannesson in J Eur Econ Assoc 6:845–863, 2008; Beretti et al. in Kyklos 66(1):63–77, 2013) to reduce the likelihood to backfire against the cause it is meant to promote. This mechanism consists of a monetary payment for the pro-social behavior and it offers agents the choice to either keep the money for themselves or to direct it to a charity. We show that this legal procedure dominates others more classical procedures because it taps wisely into the motivational heterogeneity of individuals. It uses a self-selection mechanism to match adequate monetary incentives with individuals’ types regarding intrinsic motivations. It may even turn a situation subject to crowding-out into a crowding-in outcome. more...
Published: 2019
Full Text: View/download PDF

33. When more is not better: three common mistakes in health messaging interventions

Author: Naoufel Mzoughi, Katherine Farrow, Gilles Grolleau, Université Paris Nanterre (UPN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de la Recherche Agronomique (INRA), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: Persuasion, persuasion, business.industry, Heuristic, Health Policy, media_common.quotation_subject, 05 social sciences, Internet privacy, Health Behavior, Persuasive Communication, Psychological intervention, identifiability bias, Health Promotion, health messaging campaigns, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 050105 experimental psychology, Health Communication, 0502 economics and business, Humans, 050211 marketing, 0501 psychology and cognitive sciences, Psychology, business, social norms, media_common
Abstract: Health messaging interventions frequently make three well-intentioned but mistaken choices in their communications strategies. To increase their persuasiveness, these messages frequently call attention to the greatest possible numbers of people engaging in undesirable behavior, victims of this behavior, and reasons why one should change the behavior. We raise recent research suggesting how and why the intuitively attractive more-is-better heuristic can be unproductive, and suggest ways to overcome these pitfalls. more...
Published: 2019
Full Text: View/download PDF

34. THE SCOPE FOR THE STRATEGIC USE OF SCANDALS

Author: Grolleau, Gilles, Marciano, Alain, Mzoughi, Naoufel, Centre de Recherche sur l'ENtreprise [Dijon] (CEREN), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Montpellier Recherche en Economie (MRE), Université de Montpellier (UM), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de la Recherche Agronomique (INRA), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) more...
Subjects: [SHS.ECO]Humanities and Social Sciences/Economics and Finance, [SHS]Humanities and Social Sciences
Abstract: International audience; Scandals are pervasive in many areas of human life. Organizational leaders are human, and sometimes they are involved in scandalous issues that affect the organization. We propose a characterization of scandals that explicitly considers the potential benefits of scandals for transgressors. Even if scandals are frequently considered as undesirable for the targets or transgressors, we develop four rationales by which scandals can be beneficial for the scandal targets. First, scandals can propel the individual and the organization or cause into the limelight and generate a low cost publicity that can serve the interest of the target, e.g., by increasing the visibility and salience of a given issue or getting the right-to-explain what happened with great mass media coverage. Second, scandal targets can decide to serve as altruistic or egoistic scapegoats. Third, scandal targets can use scandals to divert attention from more serious issues. Fourth, scandals can constitute a way to disadvantage competitors or foes who would be more harmed than the initial self-inflicted target. Moreover, for each rationale, we suggest some conditions of its success. Anecdotal evidence and real-world examples are also provided to illustrate and support these rationales. more...
Published: 2019
Full Text: View/download PDF

35. Identifying key factors leading to the optimal care pathway for patients with ST-segment elevation myocardial infarction: Results from the RESCAMIP registry

Author: Emilie Dehours, Rescamip investigators, Fanny Pélissier, Sabrina Grolleau, Sébastien Lamy, Thibault Lhermusier, Olivier Azema, Frederic Balen, Sandrine Charpentier, CHU Toulouse [Toulouse], Epidémiologie et analyses en santé publique : risques, maladies chroniques et handicaps (LEASP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Universitaire de Technologie - Paul Sabatier (IUT Paul Sabatier), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées more...
Subjects: Male, Emergency Medical Services, medicine.medical_specialty, Time Factors, [SDV]Life Sciences [q-bio], Disease, 030204 cardiovascular system & hematology, Chest pain, Health Services Accessibility, Time-to-Treatment, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Reperfusion therapy, Risk Factors, medicine, Humans, ST segment, Registries, 030212 general & internal medicine, Myocardial infarction, Healthcare Disparities, Aged, Aged, 80 and over, business.industry, General Medicine, Odds ratio, Middle Aged, medicine.disease, Emergency Medical Dispatcher, Confidence interval, 3. Good health, Outcome and Process Assessment, Health Care, Transportation of Patients, Treatment Outcome, Key factors, Emergency medicine, Critical Pathways, ST Elevation Myocardial Infarction, Female, France, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Summary Background In France, when someone presents with chest pain, it is recommended to call a health emergency number. The patient talks with an emergency doctor at a medical dispatch centre, who decides whether (or not) to send a Mobile Intensive Care Unit (MICU). Patients with an ST-segment elevation myocardial infarction (STEMI) should have an MICU as their first medical contact, to speed up confirmation of diagnosis and enable them to benefit from reperfusion therapy as quickly as possible. Aim To evaluate the proportion of patients with STEMI benefiting from an optimal care pathway, and to identify the key factors leading to this pathway. Methods RESCAMIP was a multicentre registry conducted between May 2015 and May 2017 in Midi-Pyrenees. All patients treated for STEMI within 12 hours of symptoms onset, without initially going into cardiac arrest, were included. Results Data from 1371 patients with STEMI were analysed; 60% had an MICU as their first medical contact. In-hospital mortality was 4%. Factors associated with calling the medical dispatch centre when presenting chest pain were: age > 65 years (odds ratio [OR] 1.37, 95% confidence interval [CI] 1.02–1.83), personal history of cardiovascular disease (OR 1.9, 95% CI 1.22–2.96) and having cardiovascular risk factors (OR 1.84, 95% CI 1.35–2.5). Factors associated with sending an MICU as first medical contact were: male sex (OR 2.11, 955 CI 1.49–2.99) and personal history of cardiovascular disease (OR 1.69, 95% CI 1.07–2.65). Conclusions The proportion of patients with STEMI going through non-optimal pathways was 40% in our area. We note that there are sex-based inequalities in accessing MICUs. more...
Published: 2019
Full Text: View/download PDF

36. Attracting employees in developing countries through corporate social responsibility initiatives

Author: Naoufel Mzoughi, Gilles Grolleau, Latifa Barbara, MDI Alger Business School, Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Centre d'Economie et de Sociologie Rurales Appliquées à l'Agriculture et aux Espaces Ruraux (CESAER), Institut National de la Recherche Agronomique (INRA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, and Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) more...
Subjects: people, business.industry, media_common.quotation_subject, JEL: J - Labor and Demographic Economics/J.J2 - Demand and Supply of Labor/J.J2.J28 - Safety • Job Satisfaction • Related Public Policy, 05 social sciences, JEL: M - Business Administration and Business Economics • Marketing • Accounting • Personnel Economics/M.M1 - Business Administration/M.M1.M14 - Corporate Culture • Diversity • Social Responsibility, 1. No poverty, Developing country, Context (language use), JEL: J - Labor and Demographic Economics/J.J3 - Wages, Compensation, and Labor Costs/J.J3.J31 - Wage Level and Structure • Wage Differentials, Public relations, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, General Business, Management and Accounting, green, 8. Economic growth, 0502 economics and business, Corporate social responsibility, 050211 marketing, business, Social responsibility, 050203 business & management, Finance, performance, Reputation, media_common
Abstract: International audience; Individuals have mainly preferences for ethical jobs, and companies with bad ethical reputation have to offer higher wages to recruit. Social responsibility concerns are context dependent. Individuals' choices are not all predominantly oriented toward the moral high ground. A significant proportion of respondents refuse to trade-off ethical preferences for money. more...
Published: 2019
Full Text: View/download PDF

37. Galvanic corrosion in marine environments: Effects associated with the inversion of polarity of Zn/carbon steel couples

Author: Anne-Marie Grolleau, René Sabot, Emilie François, Philippe Refait, Marc Jeannin, Laboratoire des Sciences de l'Ingénieur pour l'Environnement - UMR 7356 (LaSIE), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS), and Naval Group more...
Subjects: Materials science, Carbon steel, Polarity (physics), 020209 energy, Inversion (geology), chemistry.chemical_element, 02 engineering and technology, Zinc, engineering.material, Rust, [SPI]Engineering Sciences [physics], 0202 electrical engineering, electronic engineering, information engineering, Materials Chemistry, Environmental Chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], Mechanical Engineering, Metallurgy, Metals and Alloys, General Medicine, Oxygen reduction, Surfaces, Coatings and Films, Galvanic corrosion, chemistry, Mechanics of Materials, engineering
Abstract: International audience
Published: 2019
Full Text: View/download PDF

38. Dimerization Study of Two Small Push-Pull Chromophores Based on Arylamine Donor Groups

Author: Malacrida, Claudia, Habibi, Amir Hossein, Gámez‐Valenzuela, Sergio, Lenko, Illia, Marqués, Pablo Simón, Labrunie, Antoine, Grolleau, Jérémie, López Navarrete, Juan, Ruiz Delgado, M. Carmen, Cabanetos, Clément, Blanchard, Philippe, Ludwigs, Sabine, Universität Stuttgart [Stuttgart], MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidad de Málaga [Málaga] = University of Málaga [Málaga], Univ Stuttgart, Inst Polymerchem, and BLANCHARD, Philippe more...
Subjects: [CHIM.MATE] Chemical Sciences/Material chemistry, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [CHIM] Chemical Sciences, [CHIM]Chemical Sciences, [CHIM.MATE]Chemical Sciences/Material chemistry, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

39. The PLATO Solar-like Light-curve Simulator A tool to generate realistic stellar light-curves with instrumental effects representative of the PLATO mission

Author: K. Belkacem, Martin Pertenais, Daniel R. Reese, V. Marchiori, R. Samadi, Anko Börner, Sébastien Deheuvels, J. J. Green, E. Grolleau, A. Deru, Benoit Mosser, Alexis M. S. Smith, Yveline Lebreton, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA (UMR_8109)), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), University of São Paulo (USP), German Aerospace Center (DLR), Institut de Physique de Rennes (IPR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Centre National d'Etudes Spatiales - Direction Des Lanceurs. (CNES), CNES, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidade de São Paulo = University of São Paulo (USP), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS) more...
Subjects: Extrasolare Planeten und Atmosphären, Weltrauminstrumente, FOS: Physical sciences, techniques: image processing, Context (language use), asteroseismology, 01 natural sciences, Asteroseismology, methods: numerical, techniques image processing, techniques: photometric, Planet, 0103 physical sciences, Instrumentation and Methods for Astrophysics (astro-ph.IM), 010303 astronomy & astrophysics, Solar and Stellar Astrophysics (astro-ph.SR), ComputingMilieux_MISCELLANEOUS, Simulation, Echtzeit-Datenprozessierung, Physics, [PHYS]Physics [physics], Pixel, 010308 nuclear & particles physics, Microscanning, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Astronomy and Astrophysics, [PHYS.ASTR.SR]Physics [physics]/Astrophysics [astro-ph]/Solar and Stellar Astrophysics [astro-ph.SR], techniques photometric, Photometry (astronomy), Astrophysics - Solar and Stellar Astrophysics, Space and Planetary Science, Parametric model, stars: oscillations, Astrophysics::Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, methods numerical, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], stars oscillations
Abstract: The preparation of science objectives of the ESA's PLATO space mission will require the implementation of hare-and-hound exercises relying on the massive generation of representative simulated light-curves. We developed a light-curve simulator named the PLATO Solar-like Light-curve Simulator (PSLS) in order to generate light-curves representative of typical PLATO targets, i.e. showing simultaneously solar-like oscillations, stellar granulation, and magnetic activity. At the same time, PSLS also aims at mimicking in a realistic way the random noise and the systematic errors representative of the PLATO multi-telescope concept. To quantify the instrumental systematic errors, we performed a series of simulations at pixel level that include various relevant sources of perturbations expected for PLATO. From the simulated pixels, we extract the photometry as planned on-board. The simulated light-curves are then corrected for instrumental effects using the instrument Point Spread Functions reconstructed on the basis of a microscanning technique that will be operated during the in-flight calibration phases. These corrected light-curves are then fitted by a parametric model, which we incorporated in PSLS. We show that the instrumental systematic errors dominate the signal only at frequencies below 20muHz and are found to mainly depend on stellar magnitude and on the detector charge transfer inefficiency. To illustrate how realistic our simulator is, we compared its predictions with observations made by Kepler on three typical targets and found a good qualitative agreement with the observations. PSLS reproduces the main properties of expected PLATO light-curves. Its speed of execution and its inclusion of relevant stellar signals as well as sources of noises representative of the PLATO cameras make it an indispensable tool for the scientific preparation of the PLATO mission., 19 pages, 16 figures, Astronomy & Astrophysics (in press) more...
Published: 2019
Full Text: View/download PDF

40. Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System

Author: M. Duong, Nicholas Moore, Vanessa Barbet, N. Thurin, Régis Lassalle, Sinem Ezgi Gulmez, S. Duret, A. Grolleau, Cécile Droz-Perroteau, Grolleau, Adeline, CHU Bordeaux [Bordeaux], Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux PharmacoEpi, Inserm CIC1401, Université de Bordeaux, Université de Bordeaux (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was supported by an unconditional public joint grant from Direction Générale de la Santé (DGS), from Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) of Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), Régime Social Indépendants (RSI) and Caisse Nationale de Solidarité́ pour l’Autonomie (CNSA), as part of the general call for projects by IReSP (Appel à Projets, Institut de Recherche en Santé Publique)., and Cette recherche a bénéficié de l’aide conjointe de la Direction Générale de la Santé (DGS), de la Mission recherche de la Direction de la recherche, des études, de l’évaluation et des statistiques (MiRe-DREES) de la Caisse Nationale d’Assurance Maladie des Travailleurs Salariés (CNAMTS), du Régime Social des Indépendants (RSI) et de la Caisse Nationale de Solidarité pour l’Autonomie (CNSA), dans le cadre de l’appel à projets général lancé par l’IReSP (Institut de Recherche en Santé Publique). more...
Subjects: Male, pharmacoepidemiology, Databases, Factual, Atorvastatin, Antibiotics, étude cas-population, Toxicology, 030226 pharmacology & pharmacy, Esomeprazole, 0302 clinical medicine, Pharmacology (medical), 030212 general & internal medicine, Omeprazole, media_common, base de données, education.field_of_study, Middle Aged, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 3. Good health, Hospitalization, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Liver, Pharmaceutical Preparations, pharmacoépidémiologie, Population study, Chemical and Drug Induced Liver Injury, case-population, medicine.drug, Drug, medicine.medical_specialty, drug exposure, medicine.drug_class, media_common.quotation_subject, Population, Erythromycin, 03 medical and health sciences, Internal medicine, medicine, Acute liver injury, Data Systems, Humans, education, Pharmacology, business.industry, claims database, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, exposition médicamenteuse, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, hépatite aiguë, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business
Abstract: This is the accepted manuscript of this article.; International audience; Introduction: Acute liver injury (ALI) is a major reason for stopping drug development or removing drugs from the market. Hospitalisation for ALI is relatively rare for marketed drugs, justifying studies in large-scale databases such as the nationwide Système National des Données de Santé (SNDS) that covers 99% of the French population.Methods: SNDS was queried over 2010-2014 for all hospital admissions for acute toxic liver injuries not associated with a possible other cause, using a case-population approach. Exposures of interest were drugs dispensed from 7 to 60 days before date of admission. Individual drugs were analysed by their frequency (if ≥ 5 cases), and by the ratio of exposed cases to the number of exposed subjects and to exposed patient-time in the general population over the same time-frame.Results: Over 5 years, 4,807 cases of ALI were identified, mean age 54.5, 59% women, 76% exposed to at least one of 249 different drugs. Drugs most commonly identified were non-overdose paracetamol (31% of cases), esomeprazole or omeprazole (18%), phloroglucinol, domperidone, coamoxiclav, furosemide, atorvastatin (more than 250 cases each). When compared to population exposures, the highest per-person risks were observed with antimycobacterial antibiotics with 1 case for 1,000 or fewer users, followed by colestyramine and erythromycin (around 1/5,300), antiepileptic drugs, anticoagulants, anti-Alzheimer drugs (1/6,000 - 1/10,000 users). When a person-time approach is considered, the drugs with the highest per-tablet risk were still the antituberculosis drugs followed by a number of other antibiotics. Conclusions: This nationwide study describes drugs associated with ALI, according to absolute population burden, to per-patient and per-tablet risk. Some of these associations may be spurious, others causal, and others yet were unexpected. Systematic analysis of drug classes will look for outliers within each class that could raise signals of unexpected hepatic toxicity. more...
Published: 2018
Full Text: View/download PDF

41. What did you do before? Moral (in)constency in pro-environmental behavior

Author: Clot, Sophie, Grolleau, Gilles, Ibanez, Lisette, University of Reading (UOR), Centre d'Economie de l'Environnement - Montpellier - UMR 5211 (CEE-M), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Ibanez, Lisette more...
Subjects: [SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2019

42. Encouraging energy conservation: is less more?

Author: Farrow, Katherine, Grolleau, Gilles, Mzoughi, Naoufel, EconomiX, Université Paris Nanterre (UPN)-Centre National de la Recherche Scientifique (CNRS), International Transport Forum, OCDE, Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and Organisation de Coopération et de Développement Economiques = Organisation for Economic Co-operation and Development (OCDE) more...
Subjects: climate change, fossil fuels, economics, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS, science, solutions, energy
Abstract: International audience
Published: 2019

43. Synthesis via direct (hetero)arylation polymerization, electrochemical and optical properties of poly (3,4-disubstituted)thiophenes

Author: Jérémie Grolleau, Pierre Frère, Stéphanie Legoupy, Frédéric Gohier, MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), MOLTECH-ANJOU (MOLTECH-ANJOU), and Université d'Angers (UA)-Centre National de la Recherche Scientifique (CNRS) more...
Subjects: chemistry.chemical_classification, Polymers and Plastics, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Electron donor, 02 engineering and technology, Polymer, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Acceptor, 0104 chemical sciences, chemistry.chemical_compound, [CHIM.POLY]Chemical Sciences/Polymers, chemistry, Polymerization, Polymer chemistry, Materials Chemistry, Alkoxy group, 0210 nano-technology, HOMO/LUMO, Alkyl, Visible spectrum
Abstract: International audience; Some poly (3,4-disubstituted)thiophenes bearing both cyano and alkoxy or thioalkoxy groups have been synthesizedby direct (hetero)arylation polymerization (DHAP) of 2-iodo-3,4-disubstituted thiophenes. The electrondonor and acceptor properties of substituents in positions 3 and 4 allow to adjust the HOMO and LUMO levels.On the other hand, in order to avoid the polymer solubility problems, long branched or unbranched alkyl chainshave also been introduced. Thus polymers with alkoxy groups have led to complete absorption in the wavelengthrange of the visible spectrum whereas in the presence of thioalkoxy groups, the absorption of the visiblespectrum is only partial. Theoretical calculations have shown that sulphur creates torsions leading to a nonplanarpolymer chain. more...
Published: 2019
Full Text: View/download PDF

44. Does advertising the green benefits of products contribute to sustainable development goals? A quasi-experimental test of the dilution effect

Author: Naoufel Mzoughi, Gilles Grolleau, Angela Sutan, Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Unité de recherche d'Écodéveloppement (ECODEVELOPPEMENT), Institut National de la Recherche Agronomique (INRA), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) more...
Subjects: Strategy and Management, media_common.quotation_subject, Geography, Planning and Development, behavioral economics, 010501 environmental sciences, Management, Monitoring, Policy and Law, eco-label, Behavioral economics, 01 natural sciences, Perceived quality, dilution model, 0502 economics and business, Quality (business), Business and International Management, Anecdotal evidence, 0105 earth and related environmental sciences, media_common, Sustainable development, 05 social sciences, Advertising, environmental information, green products, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, Test (assessment), Harm, Ask price, quality, [SHS.GESTION]Humanities and Social Sciences/Business administration, Psychology, 050203 business & management
Abstract: International audience; Using two studies, we examine the dilution effect for green products, by testing whether advertising green benefits decreases their perceived instrumentality and thus harms sustainable development. We use a between‐subject design and ask participants to evaluate the efficacy of a pen (Study 1) and a dish detergent (Study 2) with and without environmental attributes. Our results are inconsistent with the predictions of the dilution model because the perceived instrumentality of both products does not decrease when environmental benefits are added. Our findings are relevant for eco‐labeling given anecdotal evidence suggesting that adding green information can harm the perceived quality of products. more...
Published: 2019
Full Text: View/download PDF

45. Pourquoi pense-t-on que les produits bio sont 'moins bons' ?

Author: Sutan, Angela, Grolleau, Gilles, Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centre d'Economie de l'Environnement - Montpellier - FRE2010 (CEE-M), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM) more...
Subjects: [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract: National audience
Published: 2019

46. Degradation studies on organophosphate methyl parathion mediated by silver-titania core-shell nanoparticles

Author: Farooji, Somayeh Talebzadeh, Forato, Florian, Bujoli, Bruno, Trammell, Scott, Grolleau, Stephane, Pal, Hemant, clémence queffélec, Knight, David, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Institut des Matériaux Jean Rouxel (IMN), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN), Florida Institute of Technology [Melbourne], Université de Nantes (UN), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS), and Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS) more...
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: National Meeting of the American-Chemical-Society (ACS), Orlando, FL, MAR 31-APR 04, 2019
Published: 2019

47. Non-photochemical catalytic hydrolysis of methyl parathion using core–shell Ag@TiO 2 nanoparticles

Author: Talebzadeh, Somayeh, Forato, Florian, Bujoli, Bruno, Trammell, Scott, Grolleau, Stéphane, Pal, Hemant, Queffelec, Clémence, Knight, D. Andrew, Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) more...
Subjects: [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

48. Time4Sys – Integrating Timing Verification in your Engineering Practices

Author: Fejoz, Loïc, Havet, Lionel, Didier, Aurélien, Viaud, Benoit, Bui Long, Anh-Toan, Nguyen, Thanh Dat, Ouhammou, Yassine, Grolleau, Emmanuel, Gogonel, Adriana, Maxim, Cristian, Cucu-Grosjean, Liliana, Henia, Rafik, Rioux, Laurent, Sordon, Nicolas, Ayache, Nicolas, Rehm, Joris, Realtime-at-Work (RTaW), ARTAL Technologies, Laboratoire d'Informatique et d'Automatique pour les Systèmes (LIAS), Université de Poitiers-ENSMA, Adapter le raisonnement pire cas à différentes criticités (KOPERNIC), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Models and methods of analysis and optimization for systems with real-time and embedded contraints (AOSTE2 ), Thales Research and Technology [Palaiseau], THALES, ClearSy Systems Engineering, FUI Waruna, and THALES [France] more...
Subjects: [INFO.INFO-ES]Computer Science [cs]/Embedded Systems, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018

49. Solid-State Emission Enhancement via Molecular Engineering of Benzofuran Derivatives

Author: Jérémie Grolleau, Magali Allain, William G. Skene, Ravil Petrov, Pierre Frère, MOLTECH-Anjou, Université d'Angers (UA)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Département de Chimie [Montréal], and Université du Québec à Montréal = University of Québec in Montréal (UQAM) more...
Subjects: Nitrile, General Chemical Engineering, Intermolecular force, Stacking, 02 engineering and technology, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Fluorescence, Article, 0104 chemical sciences, Molecular engineering, Crystal, lcsh:Chemistry, chemistry.chemical_compound, Crystallography, chemistry, lcsh:QD1-999, Furan, Benzofuran, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: A series of linear benzofuran derivatives consisting of either a vinylene or a cyanovinylene were prepared in order to investigate their emission properties. The X-ray crystallography of structurally similar derivatives was also evaluated. The crystalline structures of the vinylene derivatives showed only lateral contacts that involved the benzofurans and no π-stacking. In contrast, π-stacking was observed for the bisbenzofuran and benzofuran-phenyl cyanovinylene derivatives. No intermolecular π–π stacking was observed for the extended cyanovinylene structures. Intermolecular bonding between the nitrile and a furan atom was found. The fluorescence quantum yields (Φfl) of the vinylene derivatives were consistently high (>50%) in both solution and the crystal state. The exception was the benzofuran-furan-vinylene-phenyl, the Φfl of which was more...
Published: 2018
Full Text: View/download PDF

50. Evaluation of performance improvement by model predictive control in a renewable energy system with hydrogen storage

Author: Pascal Brault, Yoann Stevenin, David Morin, Cédric Grolleau, Groupe de recherches sur l'énergétique des milieux ionisés (GREMI), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), and POWIDIAN more...
Subjects: Renewable Energy, Sustainability and the Environment, Energy management, 020209 energy, [SPI.PLASMA]Engineering Sciences [physics]/Plasmas, Energy Engineering and Power Technology, 02 engineering and technology, Hydrogen tank, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 7. Clean energy, Automotive engineering, Sizing, [SPI.MAT]Engineering Sciences [physics]/Materials, Model predictive control, Hydrogen storage, Fuel Technology, 13. Climate action, Greenhouse gas, 0202 electrical engineering, electronic engineering, information engineering, Environmental science, Diesel generator, Performance improvement, 0210 nano-technology
Abstract: International audience; Nowadays islanded microgrids mostly rely on diesel generator. In order to reduce greenhouse emissions, two islanded microgrids with hydrogen storage have been installed and are currently working autonomously in Reunion Island and France. Energy management implemented on these stations fall in the myopic control category. This study aims to determine the performance improvement that could be achieve on such stations using model predictive control. Ability to supply to the loads and energy losses minimisation are our main objectives. Lifetime degradation is also taken in consideration. Simulations shows that significant improvement can be brought, with a 76% decrease of the station's defaults time and better fill rate of hydrogen tank and batteries. In the meantime, chemical and electrical losses are reduced by 38 and 11%, and the batteries degradations are decreased by around 1%. The relevance of taking into account the electrolyser and fuel cell degradations depends on the time-step of the control. These results give a performance target in order to implement a real-time model predictive control in the microgrids, and eventually can be used to better sizing of future microgrids with similar architecture. more...
Published: 2018
Full Text: View/download PDF

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Publication Type

Database

390 results on '"Grolleau A"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources