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Your search keyword '"H. Zattara-Cannoni"' showing total 2 results
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2 results on '"H. Zattara-Cannoni"'

1. Molecular and fluorescence in situ hybridization analysis of a 10;11 rearrangement in a case of infant acute monocytic leukemia

Author

H. Zattara-Cannoni, Marie Christine Bustos-Bernard, A.M. Vagner-Capodano, Gérard Michel, Catherine Curtillet, Patrice Roll, Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Laboratoire de Biologie Cellulaire [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)

Subjects
Male, In situ, Cancer Research, Oncogene Proteins, Fusion, [SDV]Life Sciences [q-bio], Chromosomal translocation, Biology, Translocation, Genetic, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Proto-Oncogenes, Genetics, medicine, Humans, Acute monocytic leukemia, neoplasms, Molecular Biology, Gene, In Situ Hybridization, Fluorescence, ComputingMilieux_MISCELLANEOUS, Bone Marrow Transplantation, 030304 developmental biology, Chromosomal inversion, 0303 health sciences, medicine.diagnostic_test, Chromosomes, Human, Pair 10, Chromosomes, Human, Pair 11, Infant, Histone-Lysine N-Methyltransferase, Gene rearrangement, medicine.disease, Molecular biology, Molecular analysis, DNA-Binding Proteins, 030220 oncology & carcinogenesis, Chromosome Inversion, Leukemia, Monocytic, Acute, Myeloid-Lymphoid Leukemia Protein, Transcription Factors, Fluorescence in situ hybridization
Abstract

Fluorescence in situ hybridization (FISH) analysis in a case of infant acute monocytic leukemia M5 revealed a complex rearrangement between chromosomes 10 and 11, leading to the disruption of the MLL gene. Using two painting probes for chromosomes 10 and 11 and a specific probe for the MLL gene localized on 11q23, we observed a paracentric inversion of the 11q13-q23 fragment translocated to 10p12. Molecular analysis showed that AF10 localized on 10p12 was the fusion partner gene of MLL in this rearrangement (10;11). This report underlined the usefulness of FISH and molecular techniques in identifying complex rearrangements.

Published
2002
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2. Cytogenetic study of six cases of radiation-induced meningiomas

Author

A.M. Vagner-Capodano, Dominique Figarella-Branger, Patrice Roll, G Lena, H. Zattara-Cannoni, H. Dufour, F. Grisoli, Aix Marseille Université (AMU), Assistance Publique - Hôpitaux de Marseille (APHM), Laboratoire de Biologie Cellulaire [Hôpital de la Timone - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)

Subjects
Secondary cancer, Cancer Research, Pathology, medicine.medical_specialty, Neoplasms, Radiation-Induced, Malignant meningioma, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Radiation induced, Biology, 03 medical and health sciences, 0302 clinical medicine, Genetics, medicine, Meningeal Neoplasms, Humans, Molecular Biology, ComputingMilieux_MISCELLANEOUS, Chromosome Aberrations, Breakpoint, Cytogenetics, Nucleic Acid Hybridization, medicine.disease, 3. Good health, Radiation therapy, Chromosomes, Human, Pair 1, 030220 oncology & carcinogenesis, Karyotyping, Chromosome abnormality, Complication, Meningioma, 030217 neurology & neurosurgery, Chromosomes, Human, Pair 7
Abstract

It is known that, following radiotherapy, secondary cancer may occur after a long latent period. Few cytogenetic studies have been reported on tumors of the central nervous system occurring after radiotherapy. We report the cytogenetic study of six cases of radiation-induced meningiomas. In all cases, we observed the same chromosome abnormality, der(1)(1qter--1p11::22q12--22pter). SKY and CGH techniques allowed us to identify the chromosomal abnormalities. We suggest that a gene localized on 1p13 is involved in radiation-induced meningiomas.

Published
2001
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