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1. Aryl hydrocarbon receptor (AhR) transcription is decreased in skin of vitiligo patients

Author

Ahlem Ben Hmid, Chayma Lajnef, Raja Rekik, Melika Ben Ahmed, Ines Zaraa, Imen Zamali, Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Faculté de Médecine de Tunis, Université de Tunis El Manar (UTM), Laboratoire d'immunologie clinique [Institut Pasteur de Tunis], and Hôpital La Rabta [Tunis]

Subjects
0301 basic medicine, Adult, Male, Adolescent, Transcription, Genetic, Vitiligo, Dermatology, 03 medical and health sciences, Young Adult, Transcription (biology), Medicine, Humans, Genetic Predisposition to Disease, RNA, Messenger, ComputingMilieux_MISCELLANEOUS, Aged, Skin, biology, business.industry, Interleukins, Middle Aged, Aryl hydrocarbon receptor, medicine.disease, Molecular biology, 030104 developmental biology, Receptors, Aryl Hydrocarbon, biology.protein, Female, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience

Published
2017
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2. Immunohistological study of tight junction protein expression in mal de Meleda

Author

Haifa Tounsi, Mourad Mokni, Samir Boubaker, Ines Zaraa, Monia Kacem, Hela Zribi, Faouzia Agili, Laboratoire de Génomique Biomédicale et Oncogénétique - Biomedical Genomics and Oncogenetics Laboratory (LR11IPT05), Université de Tunis El Manar (UTM)-Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Laboratoire d’Anatomie Pathologique Humaine et Expérimentale, Institut Pasteur de Tunis, Département de Dermatologie, U.R. Etude des maladies héréditaires de Kératinisation, Hôpital La Rabta [Tunis], Département d'Oncologie Médicale, and Réseau International des Instituts Pasteur (RIIP)

Subjects
0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Stratum granulosum, Biology, Occludin, digestive system, Pathology and Forensic Medicine, Cell membrane, 03 medical and health sciences, Young Adult, Structural Biology, Keratoderma, Palmoplantar, Claudin-1, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Tight Junction Proteins, integumentary system, Tight junction, urogenital system, Middle Aged, Molecular biology, Immunohistochemistry, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Membrane protein, Paracellular transport, Female, Epidermis, tissues, Biomarkers, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Mal de Meleda (MdM, MIM: 248300) is a rare autosomal recessive skin disorder characterized by diffuse palmoplantar keratoderma and transgressive keratosis with onset in early infancy. The gene responsible for MdM, ARS, encodes for Secreted Lys6/Plaur domain-containing protein 1 which is essential for epidermal homeostasis. Tight junctions have been proposed to have two mutually exclusive functions: a fence function which prevents the mixing of membrane proteins between the apical and basolateral membranes; and a gate function which controls the paracellular passage of ions and solutes between cells. In this study we report immunohistochemical investigations of tight junction proteins claudin-1 and occludin in MdM Tunisian families. Nine skin biopsies from patients with MdM were analyzed. The control group was formed by skin biopsies belonging to healthy individuals. Immunohistochemical study was performed on fixed sections from biopsies of four microns with the following polyclonal antibodies: anti-claudin-1 and anti-occludin. In control skin, claudin-1 exhibited membrane expression throughout the epidermis with increasing and upward intensity, whereas occludin was detected in the cell membrane of keratinocytes of the stratum granulosum. In MdM skin, claudin-1 was expressed throughout the thickness of the spinous layers with membrane staining, and occludin had cytoplasmic staining in the granular layer. The immunohistochemical expression of TJ proteins in MdM patients harbors premature expression of occludin and decreased expression of claudin-1, highlighting further evidence for disorders in epidermal homeostasis.

Published
2016
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3. Prevalence of autoantibodies in patients with pemphigus

Author

Ines Zaraa, Amel Ben Osman, Asma El Beldi, Hechmi Louzir, Mourad Mokni, Melika Ben Ahmed, Study of Hereditary Keratinization Disorders Research Unit, Hôpital La Rabta [Tunis], Dermatology Department, Habib Thameur Hospital, Laboratoire de Transmission, Contrôle et Immunobiologie des Infections - Laboratory of Transmission, Control and Immunobiology of Infection (LR11IPT02), Institut Pasteur de Tunis, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Faculté de Médecine de Tunis, and Université de Tunis El Manar (UTM)

Subjects
medicine.medical_specialty, Tunisia, business.industry, [SDV]Life Sciences [q-bio], MEDLINE, Autoantibody, Dermatology, Seroepidemiologic Studies, lcsh:RL1-803, medicine.disease, Pemphigus, Infectious Diseases, lcsh:Dermatology, medicine, Humans, In patient, business, ComputingMilieux_MISCELLANEOUS, Autoantibodies
Abstract

International audience; no abstract

Published
2012
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