1. A genome sequence from a modern human skull over 45,000 years old from Zlatý kůň in Czechia
- Author
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Marco Mattonai, Kay Prüfer, Petr Velemínský, Johannes Krause, Jaroslav Brůžek, Thomas Higham, He Yu, Maria A. Spyrou, Alexander Stoessel, Cosimo Posth, Erika Ribechini, Thibaut Devièse, Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology [Leipzig], Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, University of Oxford [Oxford], Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Pisa - Università di Pisa, Department of Anthropology, Národní muzeum, Max Planck SocietyFoundation CELLEXEuropean Research Council (ERC)European Commission324139UK Research & Innovation (UKRI)Natural Environment Research Council (NERC)Ministry of Culture of the Czech RepublicDKRVO 2019-2023/7.I.c00023272, and University of Oxford
- Subjects
Neanderthal ,[SDV]Life Sciences [q-bio] ,Population ,Evolutionary biology ,Genome ,Article ,Evolutionary genetics ,03 medical and health sciences ,Middle East ,0302 clinical medicine ,biology.animal ,Humans ,Africa ,Czech Republic ,Europe ,Female ,Infant, Newborn ,Siberia ,Skull ,education ,Ecology, Evolution, Behavior and Systematics ,ComputingMilieux_MISCELLANEOUS ,030304 developmental biology ,Whole genome sequencing ,0303 health sciences ,education.field_of_study ,Ecology ,biology ,Human evolutionary genetics ,Infant ,Newborn ,Geography ,Homo sapiens ,Biological dispersal ,Human genome ,030217 neurology & neurosurgery - Abstract
Modern humans expanded into Eurasia more than 40,000 years ago following their dispersal out of Africa. These Eurasians carried ~2–3% Neanderthal ancestry in their genomes, originating from admixture with Neanderthals that took place sometime between 50,000 and 60,000 years ago, probably in the Middle East. In Europe, the modern human expansion preceded the disappearance of Neanderthals from the fossil record by 3,000–5,000 years. The genetic makeup of the first Europeans who colonized the continent more than 40,000 years ago remains poorly understood since few specimens have been studied. Here, we analyse a genome generated from the skull of a female individual from Zlatý kůň, Czechia. We found that she belonged to a population that appears to have contributed genetically neither to later Europeans nor to Asians. Her genome carries ~3% Neanderthal ancestry, similar to those of other Upper Palaeolithic hunter-gatherers. However, the lengths of the Neanderthal segments are longer than those observed in the currently oldest modern human genome of the ~45,000-year-old Ust’-Ishim individual from Siberia, suggesting that this individual from Zlatý kůň is one of the earliest Eurasian inhabitants following the expansion out of Africa., The authors present the genome sequence of a >45,000-year-old female Homo sapiens individual from the site of Zlatý kůň, Czechia. Although radiometric dating of the human remains was inconclusive, the authors were able to use molecular methods to demonstrate that she was probably among the earliest Eurasian inhabitants following expansion out of Africa.
- Published
- 2021