1. New promising antimicrobial material based on thermoplastic polyurethane modified with polymeric biocide polyhexamethylene guanidine hydrochloride
- Author
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Valeriy Kremenitsky, Oleg Dzhuzha, Sergiy Rogalsky, Olga Bulko, Oksana Tarasyuk, Lyudmila Lyoshina, Jean-François Bardeau, L.V. Kobrina, Tetiana Cherniavska, S.V. Riabov, Institut des Molécules et Matériaux du Mans (IMMM), and Le Mans Université (UM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
chemistry.chemical_classification ,Biocide ,Thermogravimetric analysis ,02 engineering and technology ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,[PHYS.PHYS.PHYS-GEN-PH]Physics [physics]/Physics [physics]/General Physics [physics.gen-ph] ,0104 chemical sciences ,[SPI.MAT]Engineering Sciences [physics]/Materials ,chemistry.chemical_compound ,Thermoplastic polyurethane ,Differential scanning calorimetry ,chemistry ,Polyhexamethylene guanidine ,13. Climate action ,Antimicrobial polymer ,General Materials Science ,[PHYS.PHYS.PHYS-CHEM-PH]Physics [physics]/Physics [physics]/Chemical Physics [physics.chem-ph] ,0210 nano-technology ,ComputingMilieux_MISCELLANEOUS ,Polyurethane ,Nuclear chemistry - Abstract
New antimicrobial polymer composite based on commercial polyurethane (PU) Laripur®LPR9020 and polymeric biocide polyhexamethylene guanidine hydrochloride (PHMG-Cl) has been prepared by solvent casting method. Modified PU films containing from 1 to 4 wt% of PHMG-Cl were characterized in terms of mechanical, thermal and surface properties, biocide release behavior, as well as antibacterial activity against Gram-negative (Escherichia coli) and Gram-positive (Bacillus subtilis) bacterial strains. The results of mechanical testing indicate that the introduction of PHMG-Cl did not cause noticeable changes in the tensile strength of PU films, but improved their elasticity by at least 20–30%. The surface of PU/PHMG-Cl films was found to possess significantly higher hydrophobicity than neat polymer that is manifested in sharply increased water contact angle value from 72° for neat PU to 95° for PU/PHMG-Cl (2%). According to thermogravimetric analysis data, PU/PHMG-Cl composites are thermally stable to at least 300 °C which indicate their availability for melt processing by common methods. The results of differential scanning calorimetry showed reduction of both glass transition and melting temperatures of PU by more than 7 °C when contained only 1% of PHMG-Cl. Gradual release of polymeric biocide from modified PU films into water has been detected spectrophotometrically. The total biocide release ratio was found to be in the range from 29% to 48% after 50 hours immersion, depending on its content in polymer composite. PU/PHMG-Cl films showed much lower leaching rate into physiological saline solution compared to pure water (from 10% to 21% after 50 hours), which may be caused by poor solubility of polymeric biocide in sodium chloride solutions. The study of antibacterial activity of modified PU films using both disc agar diffusion and contact methods indicate high efficacy against tested microorganisms when contained 3% of polymeric biocide. So, this approach, based on the modification of PU resin with polymeric biocide PHMG-Cl, has been discussed in terms of potential medical applications when biocide release system or contact active material are necessary.
- Published
- 2021
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