1. Harmonizing Across Environmental Nanomaterial Testing Media for Increased Comparability of Nanomaterial Datasets
- Author
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Jaydee Hanson, Scott C. Brown, Mark R. Wiesner, Geert Cornelis, Sónia M. Rodrigues, Yuan Tian, Bernd Nowack, Chris D. Metcalfe, Phil Sayre, Ralf Kaegi, Amalia Turner, Iseult Lynch, Justin Kidd, Tom van Teunenbroek, Jason C. White, Robert L. Tanguay, Elijah J. Petersen, Nathalie Tefenkji, Gregory V. Lowry, Jamie R. Lead, Marina E. Vance, Jacelyn Rice, Marie Simonin, Jason M. Unrine, Frank von der Kammer, Joel A. Pedersen, Claus Svendsen, Alan J. Kennedy, Joris T.K. Quik, Stacey L. Harper, Nicholas K. Geitner, Emily S. Bernhardt, Cole W. Matson, Kim Jones, Camille de Garidel-Thoron, Jie Liu, Willie J.G.M. Peijnenburg, Christine Ogilvie Hendren, Wei Chen, Jérôme Rose, Gregory Thies, Swedish University of Agricultural Sciences (SLU), Swiss Federal Institute for Environmental Science and Technology [Dübendorf] (EAWAG), School of Geography, Earth and Environmental Sciences [Birmingham], University of Birmingham [Birmingham], Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Collège de France (CdF)-Institut national des sciences de l'Univers (INSU - CNRS)-Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA), Universität Wien, University of Strathclyde, Singapore Management University (SIS), Singapore Management University, Swiss Federal Insitute of Aquatic Science and Technology [Dübendorf] (EAWAG), Aix Marseille Université (AMU)-Institut national des sciences de l'Univers (INSU - CNRS)-Collège de France (CdF (institution))-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), University of Strathclyde [Glasgow], and Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[SDE.IE]Environmental Sciences/Environmental Engineering ,Materials Science (miscellaneous) ,Comparability ,Experimental data ,System testing ,Harmonization ,Context (language use) ,02 engineering and technology ,[CHIM.MATE]Chemical Sciences/Material chemistry ,010501 environmental sciences ,021001 nanoscience & nanotechnology ,01 natural sciences ,Data science ,Biological Testing ,Test (assessment) ,13. Climate action ,Relevance (information retrieval) ,[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology ,0210 nano-technology ,[CHIM.OTHE]Chemical Sciences/Other ,0105 earth and related environmental sciences ,General Environmental Science - Abstract
International audience; The chemical composition and properties of environmental media determine nanomaterial (NM) transport, fate, biouptake, and organism response. To compare and interpret experimental data, it is essential that sufficient context be provided for describing the physical and chemical characteristics of the setting in which a nanomaterial may be present. While the nanomaterial environmental, health and safety (NanoEHS) field has begun harmonization to allow data comparison and re-use (e.g. using standardized materials, defining a minimum set of required material characterizations), there is limited guidance for standardizing test media. Since most of the NM properties driving environmental behaviour and toxicity are medium-dependent, harmonization of media is critical. A workshop in March 2016 at Duke University identified five categories of test media: aquatic testing media, soil and sediment testing media, biological testing media, engineered systems testing media and product matrix testing media. For each category of test media, a minimum set of medium characteristics to report in all NM tests is recommended. Definitions and detail level of the recommendations for specific standardized media vary across these media categories. This reflects the variation in the maturity of their use as a test medium and associated measurement techniques, variation in utility and relevance of standardizing medium properties, ability to simplify standardizing reporting requirements, and in the availability of established standard reference media. Adoption of these media harmonization recommendations will facilitate the generation of integrated comparable datasets on NM fate and effects. This will in turn allow testing of the predictive utility of functional assay measurements on NMs in relevant media, support investigation of first principles approaches to understand behavioral mechanisms, and support categorization strategies to guide research, commercial development, and policy.
- Published
- 2019
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