Search

Your search keyword '"Josserand, Veronique"' showing total 4 results
Start Over Author "Josserand, Veronique" Publisher hal ccsd
4 results on '"Josserand, Veronique"'

1. Polysaccharide-based nanocarriers targeting CD44 for lung cancer treatment

Author

JEANNOT, Victor, MAZZAFERRO, Silvia, LAVAUD, Jonathan, JOSSERAND, Veronique, HENRY, M, SCHATZ, Christophe, LECOMMANDOUX, Sebastien, HURBIN, Amandine, COLL, J. L., INSERM U823 Grenoble, Institut Albert Bonniot, Laboratoire de Chimie des Polymères Organiques (LCPO), Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC), Team 3 LCPO : Polymer Self-Assembly & Life Sciences, and Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Ecole Nationale Supérieure de Chimie, de Biologie et de Physique (ENSCBP)-Université de Bordeaux (UB)-Institut de Chimie du CNRS (INC)

Subjects
[CHIM.POLY]Chemical Sciences/Polymers, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2014
Full Text
View/download PDF

2. In vivo autofluorescence and specific fluorescence unmixing by Non negative Matrix Factorization

Author

Montcuquet, Anne-Sophie, Herve, Lionel, Josserand, Veronique, Dinten, Jean-Marc, Mars, Jerome, GIPSA - Signal Images Physique (GIPSA-SIGMAPHY), Département Images et Signal (GIPSA-DIS), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), and Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience; Fluorescence imaging locates fluorescent markers that specifically bind to tumors: markers are injected to a patient, and optimally excited with near infrared light. To investigate thick media, as the fluorescence signal decreases with the light travel distance, the autofluorescence of biological tissues becomes a limiting factor. To remove autofluorescence and isolate specific fluorescence, a spectroscopic approach, based on Non-negative Matrix Factorization (NMF), is explored. A murine breast cancer cell line (5.106 TS/Apc cells in 200 µL sterile DPBS) was implanted subcutaneously in female nude mouse. Twelve days after tumor cells implantation, fluorescent markers (AngioStamp,Fluoptics-Grenoble-France) were injected intravenously (50 nmol, 200 µL). Two days after marker injection, a spectral acquisition is performed. The animal is illuminated with a laser at 690 nm and the emitted back fluorescence signal is collected by an imaging spectrometer coupled with a CCD camera. At this point, the ratio between non-specific fluorescence (marker everywhere but in the tumor) and specific fluorescence (marker in the tumor) is supposed to be optimal for biological analysis, but a non-negligible autofluorescence signal (with a distinct fluorescence spectrum) still remains. We process our NMF algorithm on the spectrally resolved acquisition: the algorithm successfully separated fluorescent markers from autofluorescence despite their overlapping fluorescence spectra. Unmixing results are presented on figure 1: non-specific fluorescent markers signal still remains in kidneys and everywhere else the marker has traveled, but autofluorescence has been removed. Ratio between skin and tumor has been noticeably increased. Comparable results have been obtained from two hours after injection, with only 5 nmol (200µL) of marker: tumor localization was already sensibly improved. We found that in vivo spectrally resolved acquisition combined to NMF processing successfully filters fluorescence contributions of interest from measurements impaired by unwanted signals. Autofluorescence removal is a fundamental pre-processing step to get accurate FDOT reconstructions.

Published
2010

3. Development and characterization of targeted vectors for tumor imaging and treatment

Author

Sancey, Lucie, Dufort, Sandrine, Gravier, Julien, Valero, Garcia, Hirsjärvi, Samuli, Josserand, Veronique, Boturyn, D, Dumy, P, Benoît, Jean-Pierre, Texier, Isabelle, Aouacheria, A, Coll, Jean-Luc, Univ Angers, Okina, Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Micro et Nanomédecines Biomimétiques (MINT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Bretagne Loire (UBL), Département de Chimie Moléculaire (DCM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Joseph Fourier - Grenoble 1 (UJF), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

4. In Vivo Noninvasive Optical Imaging of Receptor-Mediated RGD Internalization Using Self-Quenched Cy5-Labeled RAFT-c(-RGDfK-)(4)

Author

Jin, Zhao-Hui, Josserand, Veronique, Razkin, Jesus, GARANGER, Elisabeth, Boturyn, Didier, Favrot, Marie-Christine, Dumy, Pascal, Coll, Jean-Luc, Département de Chimie Moléculaire (DCM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université Joseph Fourier - Grenoble 1 (UJF)

Subjects
[CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results