1. A Conserved Developmental Mechanism Builds Complex Visual Systems in Insects and Vertebrates
- Author
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Volker Hartenstein, Kathy T. Ngo, Gaëlle Recher, Alessandro Brombin, Jean-Stéphane Joly, Institut des Neurosciences Paris-Saclay (NeuroPSI), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Department of Molecular Cellular and Developmental Biology, University of California [Los Angeles] (UCLA), and University of California-University of California-Howard Hughes Medical Institute (HHMI)
- Subjects
0301 basic medicine ,Cell type ,Superior Colliculi ,Neuropil ,genetic structures ,Neurogenesis ,1.1 Normal biological development and functioning ,[SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology ,Biology ,Eye ,Medical and Health Sciences ,General Biochemistry, Genetics and Molecular Biology ,Article ,Retina ,03 medical and health sciences ,0302 clinical medicine ,Underpinning research ,Biological neural network ,medicine ,Genetics ,Animals ,Eye Disease and Disorders of Vision ,Optic Lobe ,Nonmammalian ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,Phylum ,Optic Lobe, Nonmammalian ,Psychology and Cognitive Sciences ,Fishes ,Neurosciences ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Anatomy ,Biological Sciences ,Stem Cell Research ,Biological Evolution ,Neuroepithelial cell ,030104 developmental biology ,medicine.anatomical_structure ,Evolutionary biology ,Neurological ,Drosophila ,General Agricultural and Biological Sciences ,Tectum ,030217 neurology & neurosurgery ,Developmental Biology - Abstract
International audience; The visual systems of vertebrates and many other bilaterian clades consist of complex neural structures guiding a wide spectrum of behaviors. Homologies at the level of cell types and even discrete neural circuits have been proposed, but many questions of how the architecture of visual neuropils evolved among different phyla remain open. In this review we argue that the profound conservation of genetic and developmental steps generating the eye and its target neuropils in fish and fruit flies supports a homology between some core elements of bilaterian visual circuitries. Fish retina and tectum, and fly optic lobe, develop from a partitioned, unidirectionally proliferating neurectodermal domain that combines slowly dividing neuroepithelial stem cells and rapidly amplifying progenitors with shared genetic signatures to generate large numbers and different types of neurons in a temporally ordered way. This peculiar 'conveyor belt neurogenesis' could play an essential role in generating the topographically ordered circuitry of the visual system.
- Published
- 2016