1. Towards a spatiotemporally explicit toxicokinetic-toxicodynamic model for earthworm toxicity
- Author
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Christoph Oberdoerster, Yvan Capowiez, André Gergs, Gregor Ernst, Susanne Oberdoerster, Dino Liesy, Vanessa Roeben, Thomas G. Preuss, Kim J. Rakel, Resarch Institute for Operations Management [Aachen], RWTH Aachen University, Bayer Cropscience, Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH), and Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
- Subjects
Insecticides ,Environmental Engineering ,Toxicodynamics ,010504 meteorology & atmospheric sciences ,Ecology (disciplines) ,Population ,010501 environmental sciences ,01 natural sciences ,Exposure ,Soil ,Environmental Chemistry ,Animals ,Soil Pollutants ,Oligochaeta ,Pesticides ,education ,Waste Management and Disposal ,Organism ,0105 earth and related environmental sciences ,Exposure assessment ,education.field_of_study ,Modeling ,Pollution ,Bioaccumulation ,Toxicokinetics ,Population model ,13. Climate action ,Burrowing behavior ,[SDE]Environmental Sciences ,Environmental science ,Spatial variability ,Biochemical engineering ,Risk assessment - Abstract
International audience; The aim of the environmental risk assessment of chemicals is the prevention of unacceptable adverse effects on the environment. Therefore, the risk assessment for in-soil organisms, such as earthworms, is based on two key elements: the exposure assessment and the effect assessment. In the current risk assessment scheme, these two elements are not linked. While for the exposure assessment, advanced exposure models can take the spatial and temporal scale of substances into account, the effect assessment in the lower tiers considers only a limited temporal and spatial variability. However, for soil organisms, such as earthworms, those scales play a significant role as species move through the soil in response to environmental factors. To overcome this gap, we propose a conceptual integration of pesticide exposure, ecology, and toxicological effects on earthworms using a modular modeling approach. An essential part of this modular approach is the environment module, which utilizes exposure models to provide spatially and temporally explicit information on environmental variables (e.g., temperature, moisture, organic matter content) and chemical concentrations. The behavior module uses this information and simulates the feeding and movement of different earthworm species using a trait-based approach. The resulting exposure can be processed by a toxico kinetic-toxicodynamic (TKTD) module. TKTD models are particularly suitable to make effect predictions for time-variable exposure situations as they include the processes of uptake, elimination, internal distribution, and biotransformation of chemicals and link the internal concentration to an effect at the organism level. The population module incorporates existing population models of different earthworm species. The modular approach is illustrated using a case study with an insecticide. Our results emphasize that using a modular model approachwill facilitate the integration of exposure and effects and thus enhance the risk assessment of soil organisms.
- Published
- 2020