1. Détection fortuite de cmy-2 et dha-1 chez des isolats d’Escherichia coli producteurs de BLSE au Sénégal
- Author
-
F. Robin, A. Gaye-Diallo, R. Bonnet, Racha Beyrouthy, O.F. Diallo, Ahmad Iyane Sow, Awa Ba-Diallo, M.L. Dia, Seynabou Lo, France Telecom - CNET (CNET), France Télécom, Institut Mauritanien de Recherches Océanographiques et des Pêches, Faculty of Public Health [Tripoli, Liban] (FSP III), Lebanese University [Beirut], Centre Hospitalier Universitaire Clermont Ferrand, CHU Clermont-Ferrand, Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte - Clermont Auvergne (M2iSH), Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne (UCA)-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne), Institut Mauritanien de Recherches Océanographiques et des Pêches (IMROP), Faculty of Public Health [Lebanese University] (FSP III), Lebanese University [Beirut] (LU), Microbes, Intestin, Inflammation et Susceptibilité de l'Hôte (M2iSH), and Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre de Recherche en Nutrition Humaine d'Auvergne (CRNH d'Auvergne)
- Subjects
0301 basic medicine ,Transposable element ,biology ,030106 microbiology ,Esbl production ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease_cause ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,3. Good health ,Pathology and Forensic Medicine ,Microbiology ,03 medical and health sciences ,Plasmid ,Parasitology ,Large study ,medicine ,bacteria ,Gene ,Escherichia coli ,Bacteria ,ComputingMilieux_MISCELLANEOUS - Abstract
Cephalosporinases, which are naturally present in some enterobacterial species, can be mobilized by transposons, migrate to plasmids, and spread into other species such as Escherichia coli. The aim of this study was to characterize genes responsible for the production of extended-spectrum β-lactamases (ESBL) in E. coli isolates from urinary origin isolated in two hospitals in Senegal. Thus, a fortuitous discovery of plasmidic cephalosporinase in two isolates was noted. One of the isolates produced dha-1 associated with ESBL CTX-M-14, the other produced cmy-2, ESBL CTXM-15, tem-1 penicillinase, and oxa-1. This confirms the circulation of multidrug-resistant bacteria producing plasmidic cephalosporinase in Senegal. However, a large study is needed to better understand the prevalence and the nature of the genes involved.
- Published
- 2017
- Full Text
- View/download PDF