1. Specific IgE and skin prick tests to diagnose allergy to fresh and baked cow’s milk according to age: a systematic review
- Author
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Mauro Calvani, Barbara Cuomo, Annamaria Bianchi, Davide Caimmi, Stefania Arasi, Valentina Panetta, Giovanni Cosimo Indirli, Maria Carmen Verga, Arianna Dondi, Stefania La Grutta, Belcolle Hospital, Ospedale San Giuseppe da Copertino, S. Camillo-Forlanini Hospital, University of Messina, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dipartimento Salute della Donna, del Bambino e dell'Adolescente, Policlinico S.Orsola-Malpighi, Istituto di Biomedicina ed Immunologia Molecolare 'Alberto Monroy', Consiglio Nazionale delle Ricerche [Roma] (CNR), HAL-UPMC, Gestionnaire, and National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR)
- Subjects
Male ,Allergy ,Cut-offs ,Pasteurization ,Milk allergy ,Review ,medicine.disease_cause ,Immunoglobulin E ,law.invention ,030207 dermatology & venereal diseases ,0302 clinical medicine ,Allergen ,law ,Casein ,[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology ,Child ,Children ,biology ,Oral food challenge ,lcsh:RJ1-570 ,Age Factors ,food and beverages ,Predictive value ,3. Good health ,Cow’s milk allergy ,Child, Preschool ,Specificity ,Female ,α-lactalbumin ,[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology ,medicine.medical_specialty ,Positive predictive value ,Skin prick test ,β-lactoglobulin ,Risk Assessment ,03 medical and health sciences ,[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics ,medicine ,Animals ,Humans ,Skin Tests ,[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics ,business.industry ,Infant ,lcsh:Pediatrics ,Allergens ,medicine.disease ,Dermatology ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,030228 respiratory system ,Immunology ,biology.protein ,Cattle ,Milk Hypersensitivity ,business ,[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition - Abstract
International audience; Background: The diagnosis of IgE-mediated cow’s milk allergy is often based on anamnesis, and on specific IgE (sIgE) levels and/or Skin Prick Tests (SPT), which have both a good sensitivity but a low specificity, often causing positive results in non-allergic subjects. Thus, oral food challenge is still the gold standard test for diagnosis, though being expensive, time-consuming and possibly at risk for severe allergic reactions.Aim: The aim of the present study was to perform a systematic review of the studies that have so far analyzed the positive predictive values for sIgE and SPT in the diagnosis of allergy to fresh and baked cow’s milk according to age, and to identify possible cut-offs that may be useful in clinical practice.Methods: A comprehensive search on Medline via PubMed and Scopus was performed August 2017. Studies were included if they investigated possible sIgE and/or SPT cut-off values for cow’s milk allergy diagnosis in pediatric patients. The quality of the studies was evaluated according to QUADAS-2 criteria.Results: The search produced 471 results on Scopus, and 2233 on PubMed. Thirty-one papers were included in the review and grouped according to patients’ age, allergen type and cooking degree of the milk used for the oral food challenge.In children
- Published
- 2017