1. A prospective multicentre study of intravitreal injections and ocular surface in 219 patients: IVIS study
- Author
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Yannis Badri, Corinne Dot, Pierre Pradat, Yasemin Nakouri, Hussam El Chehab, Laurent Kodjikian, Thibaud Mathis, Roman Chudzinski, Antoine Levron, Frédéric Chiambaretta, Mayeul Chaperon, Sarah Verrecchia, Emilie Agard, Génétique, Reproduction et Développement (GReD), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Service d'ophtalmologie [Clermont-Ferrand], CHU Clermont-Ferrand, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), Hôpital d'Instruction des Armées Desgenettes, Service de Santé des Armées, and École du Val de Grâce (EVDG)
- Subjects
Adult ,Male ,medicine.medical_specialty ,medicine.medical_treatment ,Glaucoma ,Angiogenesis Inhibitors ,Asepsis ,[SPI.MAT]Engineering Sciences [physics]/Materials ,03 medical and health sciences ,0302 clinical medicine ,Retinal Diseases ,Quality of life ,Pain assessment ,Surveys and Questionnaires ,Ophthalmology ,medicine ,Clinical endpoint ,Humans ,Ocular Surface Disease Index ,Prospective Studies ,Aged ,Aged, 80 and over ,030203 arthritis & rheumatology ,business.industry ,Meibomian Glands ,Eye drop ,General Medicine ,Middle Aged ,medicine.disease ,eye diseases ,3. Good health ,Tears ,Intravitreal Injections ,Quality of Life ,030221 ophthalmology & optometry ,Female ,business ,Conjunctiva ,Follow-Up Studies - Abstract
PURPOSE To assess the impact of intravitreal injections (IVTI) on ocular surface of patients treated with multiple injections. METHODS Prospective, tricentric study conducted in patients treated with unilateral IVTI. An asepsis protocol with povidone-iodine was used for all patients during IVTI. The primary endpoint was the difference between the pre-IVTI Ocular Surface Disease Index (OSDI 1) score and that measured on day one (D1) post-IVTI (OSDI 2). Secondary endpoints were the evaluation of predictive factors for OSDI scores, pain assessment on D1, and the Lacrydiag® analysis of tears from the injected eye versus contralateral eye before IVTI. RESULTS Two hundred and nineteen patients with a mean age of 75.9 ± 10 years were included. The mean OSDI2-OSDI1 difference was 19.2 ± 20.6 (p
- Published
- 2021