1. Zeolite Nanoparticles Inhibit Aβ–Fibrinogen Interaction and Formation of a Consequent Abnormal Structural Clot
- Author
-
Ali Akbar Saboury, Mohammad Raoufi, Eng-Poh Ng, Alireza Lotfabadi, Rassoul Dinarvand, Mohammad Javad Hajipour, Ebrahim Barzegari, Morteza Mahmoudi, Hossein Derakhshankhah, Svetlana Mintova, Hussein Awala, Maryam Ferdousi, Kermanshah University of Medical Sciences, University of Tehran, Center of Excellence in Biothermodynamics, Tehran University of Medical Sciences (TUMS), Laboratoire catalyse et spectrochimie (LCS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut de Chimie du CNRS (INC)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), and Harvard Medical School [Boston] (HMS)
- Subjects
0301 basic medicine ,Lysis ,Materials science ,Stereochemistry ,education ,Metal Nanoparticles ,Protein Corona ,02 engineering and technology ,Fibrinogen ,03 medical and health sciences ,Alzheimer Disease ,mental disorders ,medicine ,Humans ,[CHIM]Chemical Sciences ,General Materials Science ,Zeolite ,ComputingMilieux_MISCELLANEOUS ,Amyloid beta-Peptides ,technology, industry, and agriculture ,021001 nanoscience & nanotechnology ,Blood proteins ,Small molecule ,030104 developmental biology ,Docking (molecular) ,Hemostasis ,Zeolites ,Biophysics ,0210 nano-technology ,medicine.drug - Abstract
EMT-type zeolite nanoparticles (EMT NPs) with particle size of 10–20 nm and external surface area of 200 m2/g have shown high selective affinity toward plasma protein (fibrinogen). Besides, the EMT NPs have demonstrated no adverse effect on blood coagulation hemostasis. Therefore, it was envisioned that the EMT NPs could inhibit possible β-amyloid (Aβ)–fibrinogen interactions that result in the formation of structurally abnormal clots, which are resistant to lysis, in cerebral vessels of patients with Alzheimer disease (AD). To evaluate this hypothesis, the clot formation and degradation of Aβ–fibrinogen in the presence and absence of the EMT zeolite NPs were assessed. The results clearly showed that the delay in clot dissolution was significantly reduced in the presence of zeolite NPs. By formation of protein corona, the EMT NPs showed a negligible reduction in their inhibitory strength. Docking of small molecules (Aβ–fibrinogen) introduced a novel potential inhibitory candidate. The zeolite NPs showed s...
- Published
- 2016
- Full Text
- View/download PDF