13 results on '"Moreau, Thierry"'
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2. L’accès des enfants à la justice : Bilan critique, Dalloz, coll. Thèmes et commentaires
- Author
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Siffrein-Blanc, Caroline, Moreau, Thierry, Paré, Mona, Bruning, Marielle, Aix Marseille Université (AMU), and Laboratoire de Droit Privé et de Sciences Criminelles (LDPSC)
- Subjects
[SHS.DROIT]Humanities and Social Sciences/Law - Abstract
International audience
- Published
- 2022
3. Identification of polymorphisms in Protein Coding Genes which affect eggshell quality traits in layers
- Author
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Herault, Frédéric, Diot, Christian, Burlot, Thierry, Gautron, Joël, Moreau, Thierry, Le Roy, Pascale, Hérault, Frédéric, Physiologie, Environnement et Génétique pour l'Animal et les Systèmes d'Elevage [Rennes] (PEGASE), AGROCAMPUS OUEST, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), NOVOGEN, Groupe Grimaud, Biologie des Oiseaux et Aviculture (BOA), Université de Tours-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université de Tours (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
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[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,[SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2021
4. Altération de l’activité des protéases digestives du poulet par un inhibiteur trypsique (Bowman-Birk inhibitor) présent dans l’aliment à base de pois
- Author
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RECOULES, Emilie, De Pauw, Marion, Lessire, Michel, Moreau, Thierry, Labas, Valérie, Narcy, Agnès, Rehault-Godbert, Sophie, Biologie des Oiseaux et Aviculture (BOA), Institut National de la Recherche Agronomique (INRA)-Université de Tours, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), and Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)
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[SDV.GEN]Life Sciences [q-bio]/Genetics ,[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,pois ,chromatographie d'affinité ,[SDV]Life Sciences [q-bio] ,poulet ,protéase ,[INFO]Computer Science [cs] ,nutrition animale ,digestion ,protéase gastrique ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 2018
5. La poule aux oeufs d'or
- Author
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Rehault-Godbert, Sophie, Guyot, Nicolas, Mills, Maryse, Da Silva, Mylène, Gautron, Joël, Travel, Angélique, Moreau, Thierry, Zani, Marie-Louise, Recherches Avicoles (SRA), Institut National de la Recherche Agronomique (INRA), Institut Technique de l'Aviculture et des Elevages de Petits Animaux (ITAVI), Unité de Recherches Avicoles (URA), and ITAVI
- Subjects
[SDV]Life Sciences [q-bio] ,oeuf ,egg ,poule - Abstract
La poule aux oeufs d'or. Village des sciences - INRA Nouzilly
- Published
- 2016
6. Route of administration and effectiveness of antibiotics for the eradication of initial pseudomonas aeruginosa infection: a French cystic fibrosis study
- Author
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Hocine, Mounia, Ait-Bouziad, Karim, Moreau, Thierry, Marguet, Christophe, Laboratoire Modélisation, épidémiologie et surveillance des risques sanitaires (MESuRS), Conservatoire National des Arts et Métiers [CNAM] (CNAM), Centre de recherche en épidémiologie et santé des populations (CESP), Hôpital Paul Brousse-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service de pédiatrie médicale et médecine de l'adolescent [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), and Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
[STAT]Statistics [stat] ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,[STAT.ME]Statistics [stat]/Methodology [stat.ME] ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2014
7. Primary immune deficiencies: practical questions
- Author
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Schleinitz, Nicolas, Fischer, Alain, Lajoie, Laurie, Congy-Jolivet, Nicolas, Bolzec, Armelle, Gouilleux-Gruart, Valérie, Sicard, Elodie, Sung, Hsueh Cheng, Peiretti, Frank, Moreau, Thierry, Vie, Henri, Clemenceau, Beatrice, Thibault, Gilles, Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Developpement Normal et Pathologique du Système Immunitaire, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Chaire Médecine expérimentale (A. Fischer), Collège de France (CdF (institution)), Unite Mixte de Recherche 7292, Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Immunogénétique Moléculaire (LIMT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Génétique, immunothérapie, chimie et cancer (GICC), UMR 7292 CNRS [2012-2017] (GICC UMR 7292 CNRS), Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Immunobiology of Human αβ and γδ T Cells and Immunotherapeutic Applications (CRCINA-ÉQUIPE 1), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Tours-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Collège de France - Chaire Médecine expérimentale (A. Fischer), and Université de Toulouse (UT)-Université de Toulouse (UT)
- Subjects
[SDV]Life Sciences [q-bio] - Abstract
International audience; FcγRIIIA/CD16A, the low-affinity receptor for the IgG Fc portion expressed on human CD56(dim) NK cells and involved in Ab-dependent cell cytotoxicity, is shed upon NK cell activation. We found that recombinant a disintegrin and metalloprotease (ADAM) 17 cleaved the ectodomain of FcγRIIIA/CD16A and a peptide for which the sequence encompasses aa 191-201 of the FcγRIIIA/CD16A stalk region but not ADAM10. MALDI-TOF analysis revealed that the peptide was cleaved between Ala(195) and Val(196) (i.e., 1 aa upstream of the expected position). This location of the cleavage site was confirmed by the finding that ADAM17 failed to cleave a peptide in which Ala and Val were reversed. ADAM17 was found to be expressed on NK cells, and stimulation with PMA or N-ethyl-maleimide resulted in the shedding of FcγRIIIA/CD16A and CD62L, a specific substrate of ADAM17. Selective inhibition of ADAM17 prevented the shedding of both molecules. Moreover, the shedding of FcγRIIIA/CD16A was strongly correlated with degranulation when a wide range of CD56(dim) NK cell activating receptors were stimulated, whereas both ADAM17-dependent shedding and internalization were involved in FcγRIIIA/CD16A downmodulation when the latter was engaged. Finally, the shedding of FcγRIIIA/CD16A was restricted to activated cells, suggesting that ADAM17 acts mainly, if not exclusively, in cis. Taken together, our results demonstrated for the first time, to our knowledge, at the molecular level that ADAM17 cleaves the stalk region of FcγRIIIA/CD16A and identified its cleavage site. The shedding of FcγRIIIA/CD16A was at least partially ADAM17 dependent, and it may be considered as a marker of FcγRIIIA/CD16A-independent NK cell activation highly correlated with degranulation.
- Published
- 2013
8. Testing independence between two sequential gap times in the presence of covariates
- Author
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Pénichoux, Juliette, Moreau, Thierry, Meyer, Laurence, Bouffassa, Faroudy, Hubert, Catherine, Latouche, Aurélien, Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Sud - Paris 11 (UP11), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), Centre d'études et de recherche en informatique et communications (CEDRIC), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise (ENSIIE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), INSERM UNIT 780: Epidemiology and biostatistics, Paul-Brousse Hospital, Université Paris-Sud - Paris 11 ( UP11 ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Centre d'étude et de recherche en informatique et communications ( CEDRIC ), Ecole Nationale Supérieure d'Informatique pour l'Industrie et l'Entreprise ( ENSIIE ) -Conservatoire National des Arts et Métiers [CNAM] ( CNAM ), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe de recherche PIVOT (performance et innovation des organisation, Université du Québec à Montréal ( UQAM ), and Université du Québec à Montréal (UQAM)
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Shared gamma-frailty models ,Fois de Gap ,[ INFO ] Computer Science [cs] ,[ SDV ] Life Sciences [q-bio] ,Événements récurrents ,[SDV]Life Sciences [q-bio] ,Modèles de fragilité partagé gamma ,Recurrent events ,Hétérogénéité ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,[INFO]Computer Science [cs] ,Shared gamma frailty models ,[ MATH.MATH-ST ] Mathematics [math]/Statistics [math.ST] ,Gap times ,Heterogeneity - Abstract
International audience; AbstractIn the risk analysis of sequential events, the successive gap times are often correlated, e.g. as a result of an individual heterogeneity. Correlation is usually accounted for by using a shared gamma-frailty model, where the variance φ of the random individual effect quantifies the correlation between gap times. This method is known to yield satisfactory estimates of covariate effects, but underestimates φ, which could result in a lack of power of the test of independence. We propose a new test of independence between two sequential gap times where the first is the time elapsed from the origin. The test is based on an approximation of the hazard of the second event given the first gap time in a frailty model, with a frailty distribution belonging to the power variance function family. Simulation results show an increased power of the new test compared with the test derived from the gamma-frailty model. In the realistic case where hazards are event specific, and using event-specific approaches, the proposed estimation of the variance of the frailty is less biased than the gamma-frailty based estimation for a wide range of values ( with the set of parameters considered), and similar for higher values. As an illustration, the methods are applied to a previously analysed asthma prevention trial with results showing a significant positive association between the successive times to asthmatic events. We also analyse data from a cohort of HIV-seropositive patients in order to assess the effect of risk factors on the occurrence of two successive markers of progression of the HIV disease. The results demonstrate the ability of the proposed model to account for negative correlations between gap times.
- Published
- 2012
- Full Text
- View/download PDF
9. The French Cystic Fibrosis Registry. Annual data report 2008
- Author
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Bellis, Gil, Cazes, Marie-Hélène, Lemonnier, Lydie, Moreau, Thierry, Rault, Gilles, Ravilly, Sophie, Scotet, Virginie, Sponga, Marie, Institut national d'études démographiques (INED), and Vaincre la Mucoviscidose
- Subjects
health statistics ,Cystic Fibrosis ,CYSTIC_FIBROSIS ,ANNUAL_REPORTS ,French Cystic Fibrosis Registry ,rare diseases ,HEALTH ,France ,MEDICAL_RESEARCH ,HEREDITARY_DISEASES ,medical research ,[SHS]Humanities and Social Sciences - Published
- 2011
10. Registre Français de la Mucoviscidose. Bilan des données 2009
- Author
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Bellis, Gil, Cazes, Marie-Hélène, Lemonnier, Lydie, Moreau, Thierry, Rault, Gilles, Ravilly, Sophie, Scotet, Virginie, Sponga, Marie, Institut national d'études démographiques (INED), and Vaincre la Mucoviscidose
- Subjects
recherche médicale ,CYSTIC_FIBROSIS ,DISEASES ,ANNUAL_REPORTS ,maladie rare ,rapport annuel ,France ,MEDICAL_RESEARCH ,génétique ,statistiques de santé ,Registre national de la Mucoviscidose ,[SHS]Humanities and Social Sciences - Published
- 2011
11. Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study
- Author
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Yazbeck, Chadi, Thiébaugeorges, Olivier, Moreau, Thierry, Goua, Valérie, Debotte, Ginette, Sahuquillo, Josiane, Forhan, Anne, Foliguet, Bernard, Magnin, Guillaume, Slama, Rémy, Charles, Marie-Aline, Huel, Guy, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de gynécologie-obstétrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de gynécologie et obstétrique [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-EFS-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), French Agency for Occupational and Environmental Health Safety (AFSSET), French National Institute for Population Health Surveillance (InVS), Univ. Paris– Sud, French National Institute for Health Education (INPES), Nestlé, Mutuelle Générale de l'Education Nationale (MGEN), French speaking association for the study of diabetes and metabolism (Alfediam), and French Research Agency (ANR)., Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
- Subjects
lead ,hypertension ,gestation ,cadmium ,manganese ,environmental health ,epidemiology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
International audience; BACKGROUND: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure. OBJECTIVE: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy. METHODS: One thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l' Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation. RESULTS: PIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean +/- SD, 2.2 +/- 1.4 mug/dL) than in normotensive patients (1.9 +/- 1.2 mug/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1-9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation. CONCLUSIONS: These findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH.
- Published
- 2009
12. Maternal Blood Lead Levels and the Risk of Pregnancy-Induced Hypertension: The EDEN Cohort Study.: Lead and Gestational Hypertension
- Author
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Yazbeck, Chadi, Thiébaugeorges, Olivier, Moreau, Thierry, Goua, Valérie, Debotte, Ginette, Sahuquillo, Josiane, Forhan, Anne, Foliguet, Bernard, Magnin, Guillaume, Slama, Rémy, Charles, Marie-Aline, Huel, Guy, De Lauzon-Guillain, Blandine, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de gynécologie-obstétrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Foetopathologie et placentologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de gynécologie et obstétrique [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), INSERM U823, équipe 12 (Epidémiologie Environnementale appliquée à la Reproduction et la Santé Respiratoire), Institut d'oncologie/développement Albert Bonniot de Grenoble (INSERM U823), Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-EFS-Institut National de la Santé et de la Recherche Médicale (INSERM), and French Agency for Occupational and Environmental Health Safety (AFSSET), French National Institute for Population Health Surveillance (InVS), Univ. Paris– Sud, French National Institute for Health Education (INPES), Nestlé, Mutuelle Générale de l'Education Nationale (MGEN), French speaking association for the study of diabetes and metabolism (Alfediam), and French Research Agency (ANR).
- Subjects
lead ,hypertension ,gestation ,cadmium ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,manganese ,environmental health ,epidemiology ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie - Abstract
International audience; BACKGROUND: Prior studies revealed associations of environmental lead exposure with risks of hypertension and elevated blood pressure. OBJECTIVE: We examined the effect of blood lead levels on blood pressure and the incidence of pregnancy-induced hypertension (PIH) in the second and third trimesters of pregnancy. METHODS: One thousand seventeen pregnant women were enrolled in two French municipalities between 2003 and 2005 for the EDEN (Etude des Déterminants pré et post natals du développement et de la santé de l' Enfant) cohort study. Blood lead concentrations were measured by atomic absorption spectrometry in mothers between 24 and 28 weeks of gestation. RESULTS: PIH was diagnosed in 106 subjects (10.9%). Age, parity, weight gain, alcohol, smoking habits, and calcium supplementation were comparable between hypertensive and nonhypertensive women. Lead levels were significantly higher in PIH cases (mean +/- SD, 2.2 +/- 1.4 mug/dL) than in normotensive patients (1.9 +/- 1.2 mug/dL; p = 0.02). Adjustment for potential confounder effects slightly attenuated but did not eliminate the significant association between blood lead levels and the risk of PIH (adjusted odds ratio of PIH = 3.3; 95% confidence interval, 1.1-9.7). We also observed geographic differences in lead exposure and in the incidence of PIH and found significant correlations between blood lead levels and unadjusted as well as adjusted systolic and diastolic blood pressures after 24 weeks of gestation. CONCLUSIONS: These findings confirm the relationship between blood lead levels at mid-pregnancy and blood pressure and suggest that environmental lead exposure may play an etiologic role in PIH.
- Published
- 2009
13. Annalyse de l'intéraction entre beta2-microglobuline de porc et chaînes lourdes HLA de classe I humaines : résultats préliminaires
- Author
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Magallon, Thierry, Guillaumin, Jm, Moreau, Thierry, Bruneau, Gilles, Thibault, G, Maurel, Marie-Christine, Wattier, H, Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Unité de Recherches Avicoles (URA), Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS), and ProdInra, Migration
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[SDV] Life Sciences [q-bio] ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,[SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics ,[SDV]Life Sciences [q-bio] ,[INFO]Computer Science [cs] ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,[SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics ,[INFO] Computer Science [cs] ,ComputingMilieux_MISCELLANEOUS - Abstract
National audience
- Published
- 1999
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