1. Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis
- Author
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E M Sizoo, Nadia A. Sutedja, Krista Fischer, Mark H B Huisman, L. H. van den Berg, J. H. Veldink, Y T van der Schouw, University Medical Centre Utrecht, University Medical Center [Utrecht], Neurology, and NCA - Neurodegeneration
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Adult ,Male ,medicine.medical_specialty ,Homocysteine ,Population ,Gastroenterology ,Body Mass Index ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Risk Factors ,Diabetes mellitus ,Internal medicine ,medicine ,Humans ,Risk factor ,Amyotrophic lateral sclerosis ,education ,Aged ,030304 developmental biology ,Aged, 80 and over ,2. Zero hunger ,MOTOR NEURON DISEASE ,0303 health sciences ,education.field_of_study ,business.industry ,Amyotrophic Lateral Sclerosis ,Smoking ,Middle Aged ,medicine.disease ,3. Good health ,Psychiatry and Mental health ,C-Reactive Protein ,Cholesterol ,Endocrinology ,chemistry ,Cardiovascular Diseases ,Female ,Surgery ,lipids (amino acids, peptides, and proteins) ,Self Report ,Neurology (clinical) ,business ,Body mass index ,Motor neurone disease ,030217 neurology & neurosurgery ,Lipoprotein - Abstract
International audience; ABSTRACT Objectives Reports of increased amyotrophic lateral sclerosis (ALS) with hyperlipidemia and elevated plasma homocysteine levels as well as cigarette-smoking and polymorphisms in angiogenic genes suggest a role for altered vascular homeostasis in ALS pathogenesis. We assessed the association between vascular risk factors and ALS. Methods Traditional cardiovascular risk factors (smoking, hypertension, hypercholesterolemia, diabetes and body mass index (BMI)) and cardiovascular disease prior to ALS onset established by a questionnaire were compared in 334 patients and 538 age- and sex-matched controls. Biochemical assessments (total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), hs-CRP, and homocysteine) at diagnosis were measured in blood samples of 303 patients with ALS and compared with prospectively collected data from 2100 population-based controls. Results Patients with ALS used cholesterol-lowering agents less frequently (OR=0.6, p=0.008), had a lower BMI (OR=0.9, p=0.001), a lower LDL/HDL ratio (women: OR=0.5, p
- Published
- 2011
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